In cultured granulosa cells from IVF patients, prior cetrorelix treatment produced an earlier progesterone response to hormone stimulation than prior buserelin treatment.
In plain wordsIn lab tests, granulosa cells from the cetrorelix group produced progesterone earlier after hormone stimulation than cells from the buserelin group.
- Peptide
- Cetrorelix
- Outcome
- IncreaseTiming of stimulated progesterone accumulation
- Study
humann: not reported in source
Granulosa cells from IVF patients- Comparator
- Buserelin-treated women
- Outcome group
- Sex hormones and fertility · Reproductive and sexual health
- Studied dose
- Dose not stated
Source sentences
The results showed that granulosa cells from women treated with GnRH antagonist (cetrorelix) responded earlier to the in-vitro hormone stimulation in terms of progesterone accumulation than women treated with the GnRH agonist (buserelin).
3 context sentences(design, population, supporting numbers)
Women were treated by IVF randomized either to have buserelin nasal spray from the luteal phase in the previous cycle or cetrorelix from day 6 of the cycle.
Granulosa cells, separated and washed from large follicles containing ova, were pooled.
After 48 h of pre-incubation, the granulosa cells were cultured for 4 days in medium with either added testosterone or cAMP with or without HCG, with change of medium after 2 days.