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Study · Animal study (in vivo) · mouse · 1999

5 results

Evidence that insulin-like growth factor I and growth hormone are required for prostate gland development.

Ruan W, Powell-Braxton L, Kopchick JJ, Kleinberg DL

Endocrinology1 May 1999Cited by 83 (Europe PMC)

PMID10218945 (opens in a new tab)DOI10.1210/endo.140.5.6721 (opens in a new tab)PepBankPUB-10218945
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    Des(1‑3)-IGF-I partially reversed the prostate size deficit in IGF-I-deficient mice.

    In plain wordsIn mice lacking IGF-I, des(1‑3)-IGF-I partly restored prostate size.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    IncreaseProstate gland size
    Study

    mousen: not reported in source

    IGF-I null mice
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated · 7 daysAs given in this study (mouse).

    Source sentences

    Summary
    Administration of des(1-3)-IGF-I for 7 days partially reversed the deficit by increasing those parameters of prostate development (P < 0.006).
    2 context sentences
    Summary · context
    Glands from 44-day-old IGF-I-deficient animals were not only smaller than those from wild-type mice, but also had fewer terminal duct tips and branch points and deficits in tertiary and quaternary branching (P < 0.0001), indicating a specific impairment in gland structure.
    Summary · context
    To determine whether IGF-I was important in prostate development, we examined prostate architecture in IGF-I(-/-) null mice and wild-type littermates.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    Des(1‑3)-IGF-I increased prostate terminal duct tips in IGF-I-deficient mice.

    In plain wordsIn mice lacking IGF-I, des(1‑3)-IGF-I increased prostate duct tips.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    IncreaseTerminal duct tips
    Study

    mousen: not reported in source

    IGF-I null mice
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated · 7 daysAs given in this study (mouse).

    Source sentences

    Summary
    Administration of des(1-3)-IGF-I for 7 days partially reversed the deficit by increasing those parameters of prostate development (P < 0.006).
    2 context sentences
    Summary · context
    Glands from 44-day-old IGF-I-deficient animals were not only smaller than those from wild-type mice, but also had fewer terminal duct tips and branch points and deficits in tertiary and quaternary branching (P < 0.0001), indicating a specific impairment in gland structure.
    Summary · context
    To determine whether IGF-I was important in prostate development, we examined prostate architecture in IGF-I(-/-) null mice and wild-type littermates.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    Des(1‑3)-IGF-I increased prostate branch points in IGF-I-deficient mice.

    In plain wordsIn mice lacking IGF-I, des(1‑3)-IGF-I increased prostate branch points.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    IncreaseBranch points
    Study

    mousen: not reported in source

    IGF-I null mice
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated · 7 daysAs given in this study (mouse).

    Source sentences

    Summary
    Administration of des(1-3)-IGF-I for 7 days partially reversed the deficit by increasing those parameters of prostate development (P < 0.006).
    2 context sentences
    Summary · context
    Glands from 44-day-old IGF-I-deficient animals were not only smaller than those from wild-type mice, but also had fewer terminal duct tips and branch points and deficits in tertiary and quaternary branching (P < 0.0001), indicating a specific impairment in gland structure.
    Summary · context
    To determine whether IGF-I was important in prostate development, we examined prostate architecture in IGF-I(-/-) null mice and wild-type littermates.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    Des(1‑3)-IGF-I partially reversed deficient tertiary prostate branching in IGF-I-deficient mice.

    In plain wordsIn mice lacking IGF-I, des(1‑3)-IGF-I partly restored tertiary prostate branching.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    IncreaseTertiary branching
    Study

    mousen: not reported in source

    IGF-I null mice
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated · 7 daysAs given in this study (mouse).

    Source sentences

    Summary
    Administration of des(1-3)-IGF-I for 7 days partially reversed the deficit by increasing those parameters of prostate development (P < 0.006).
    2 context sentences
    Summary · context
    Glands from 44-day-old IGF-I-deficient animals were not only smaller than those from wild-type mice, but also had fewer terminal duct tips and branch points and deficits in tertiary and quaternary branching (P < 0.0001), indicating a specific impairment in gland structure.
    Summary · context
    To determine whether IGF-I was important in prostate development, we examined prostate architecture in IGF-I(-/-) null mice and wild-type littermates.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    Des(1‑3)-IGF-I partially reversed deficient quaternary prostate branching in IGF-I-deficient mice.

    In plain wordsIn mice lacking IGF-I, des(1‑3)-IGF-I partly restored quaternary prostate branching.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    IncreaseQuaternary branching
    Study

    mousen: not reported in source

    IGF-I null mice
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated · 7 daysAs given in this study (mouse).

    Source sentences

    Summary
    Administration of des(1-3)-IGF-I for 7 days partially reversed the deficit by increasing those parameters of prostate development (P < 0.006).
    2 context sentences
    Summary · context
    Glands from 44-day-old IGF-I-deficient animals were not only smaller than those from wild-type mice, but also had fewer terminal duct tips and branch points and deficits in tertiary and quaternary branching (P < 0.0001), indicating a specific impairment in gland structure.
    Summary · context
    To determine whether IGF-I was important in prostate development, we examined prostate architecture in IGF-I(-/-) null mice and wild-type littermates.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 2

    21 Oct 2026, 13:52 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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