Skip to content

Study · Animal study (in vivo) · rat · 1999

2 results

An electrophysiological and morphological investigation of the projections of growth hormone-releasing peptide-6-responsive neurons in the rat arcuate nucleus to the median eminence and to the paraventricular nucleus.

Honda K, Bailey AR, Bull PM, Macdonald LP, Dickson SL, Leng G

Neuroscience1 Mar 1999Cited by 12 (Europe PMC)

PMID10218787 (opens in a new tab)DOI10.1016/s0306-4522(98)00532-6 (opens in a new tab)PepBankPUB-10218787
Publisher pagePubMedAsk about this study
Jump to 2 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In rats, GHRP‑6 activated three of ten tested arcuate neurons projecting to the paraventricular nucleus.

    In plain wordsIn rats, GHRP‑6 activated some arcuate neurons that projected to the paraventricular nucleus.

    Peptide
    GHRP-6
    Outcome
    IncreaseNeuronal activation
    Study

    ratn: not reported in source

    arcuate nucleus neurons projecting to paraventricular nucleus
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated · systemic injectionAs given in this study (rat).

    Source sentences

    Summary
    Three of 10 arcuate nucleus neurons that projected to the paraventricular nucleus were activated by injection of growth hormone-releasing peptide-6.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In rats, 20% of retrogradely labelled arcuate neurons expressed Fos after GHRP‑6 injection.

    In plain wordsIn rats, some arcuate neurons projecting to the paraventricular nucleus expressed Fos after GHRP‑6 injection.

    Peptide
    GHRP-6
    Outcome
    Not applicableFos expression in projecting neurons
    Study

    ratn: not reported in source

    arcuate nucleus neurons projecting to paraventricular nucleus
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated · systemic injectionAs given in this study (rat).

    Measurements

    Fos-positive projecting neurons
    20%
    retrogradely labelled neurons
    Double-labelled cells
    < 5%
    all Fos-positive arcuate neurons

    Source sentences

    Summary
    Immunocytochemical studies revealed that 20% of arcuate nucleus neurons that were retrogradely-labelled from the paraventricular nucleus were Fos-positive following growth hormone-releasing peptide-6 injection, although cells that were both Fos-positive and retrogradely-labelled accounted for less t…

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:13 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.