Early postnatal treatment with peptide preparations influences spatial navigation of young and adult rats.

Gschanes A, Windisch M

Behavioural brain research1 Apr 1999Cited by 12 (Europe PMC)

PMID10212063DOI10.1016/s0166-4328(98)00127-2PepBankPUB-10212063

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

2 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In young rats, early postnatal Cerebrolysin shortened escape latencies compared with saline on all 6 test days.
In plain wordsIn young rats, early Cerebrolysin treatment shortened maze escape times compared with saline.
Peptide
Cerebrolysin
Outcome
DecreaseEscape latency in young rats
Study
ratn: not reported in source
Early postnatal treatment followed by Morris water maze testing
Comparator
Saline-treated controls
Outcome group
Cognition and memory · Nervous system and cognition
Studied dose
10 mg/ml peptides · postnatal days 1-7As given in this study (rat).
Source sentences
Summary
In the young and young adult rats both Cere and E021 treated rats showed shorter escape latencies than saline treated controls on all 6 test days.
3 context sentences(design, population, supporting numbers)
Summary · context
In the present study the effects of early postnatal administration of Cerebrolysin (Cere, 10 mg/ml peptides) or an enriched peptide fraction of Cere (E021, 80.6 mg/ml peptides) were investigated in young, young adult, and old adult rats.
Summary · context
Rat pups received the drugs or saline for control on postnatal days 1-7.
Summary · context
The animals were tested in the Morris water maze (MWM) either in the 5th week, in the 3rd or the 16th month of life for 6 consecutive days (test days 1-6), eight trials per day.
Report a problemFND-1021206301
02AnimalAnimal study (in vivo)Efficacy outcome
In young adult rats, early postnatal Cerebrolysin shortened escape latencies compared with saline on all 6 test days.
In plain wordsIn young adult rats, early Cerebrolysin treatment shortened maze escape times compared with saline.
Peptide
Cerebrolysin
Outcome
DecreaseEscape latency in young adult rats
Study
ratn: not reported in source
Early postnatal treatment followed by Morris water maze testing
Comparator
Saline-treated controls
Outcome group
Cognition and memory · Nervous system and cognition
Studied dose
10 mg/ml peptides · postnatal days 1-7As given in this study (rat).
Source sentences
Summary
In the young and young adult rats both Cere and E021 treated rats showed shorter escape latencies than saline treated controls on all 6 test days.
3 context sentences(design, population, supporting numbers)
Summary · context
In the present study the effects of early postnatal administration of Cerebrolysin (Cere, 10 mg/ml peptides) or an enriched peptide fraction of Cere (E021, 80.6 mg/ml peptides) were investigated in young, young adult, and old adult rats.
Summary · context
Rat pups received the drugs or saline for control on postnatal days 1-7.
Summary · context
The animals were tested in the Morris water maze (MWM) either in the 5th week, in the 3rd or the 16th month of life for 6 consecutive days (test days 1-6), eight trials per day.
Report a problemFND-1021206302

Studies that did not test the peptide alone6

In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Cerebrolysin.

03AnimalNot a test of Cerebrolysin aloneAnimal study (in vivo)Efficacy outcome
In young rats, early postnatal E021, an enriched Cerebrolysin peptide fraction, shortened escape latencies versus saline on all 6 test days.
In plain wordsIn young rats, the enriched Cerebrolysin fraction E021 shortened maze escape times compared with saline.
Peptide
Cerebrolysin
Outcome
DecreaseE021 escape latency in young rats
Study
ratn: not reported in source
Early postnatal treatment followed by Morris water maze testing
Comparator
Saline-treated controls
Outcome group
Cognition and memory · Nervous system and cognition
Source sentences
Summary
In the young and young adult rats both Cere and E021 treated rats showed shorter escape latencies than saline treated controls on all 6 test days.
3 context sentences(design, population, supporting numbers)
Summary · context
In the present study the effects of early postnatal administration of Cerebrolysin (Cere, 10 mg/ml peptides) or an enriched peptide fraction of Cere (E021, 80.6 mg/ml peptides) were investigated in young, young adult, and old adult rats.
Summary · context
Rat pups received the drugs or saline for control on postnatal days 1-7.
Summary · context
The animals were tested in the Morris water maze (MWM) either in the 5th week, in the 3rd or the 16th month of life for 6 consecutive days (test days 1-6), eight trials per day.
In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.
Report a problemFND-1021206303
04AnimalNot a test of Cerebrolysin aloneAnimal study (in vivo)Efficacy outcome
In young adult rats, early postnatal E021, an enriched Cerebrolysin peptide fraction, shortened escape latencies versus saline on all 6 test days.
In plain wordsIn young adult rats, the enriched Cerebrolysin fraction E021 shortened maze escape times compared with saline.
Peptide
Cerebrolysin
Outcome
DecreaseE021 escape latency in young adult rats
Study
ratn: not reported in source
Early postnatal treatment followed by Morris water maze testing
Comparator
Saline-treated controls
Outcome group
Cognition and memory · Nervous system and cognition
Source sentences
Summary
In the young and young adult rats both Cere and E021 treated rats showed shorter escape latencies than saline treated controls on all 6 test days.
3 context sentences(design, population, supporting numbers)
Summary · context
In the present study the effects of early postnatal administration of Cerebrolysin (Cere, 10 mg/ml peptides) or an enriched peptide fraction of Cere (E021, 80.6 mg/ml peptides) were investigated in young, young adult, and old adult rats.
Summary · context
Rat pups received the drugs or saline for control on postnatal days 1-7.
Summary · context
The animals were tested in the Morris water maze (MWM) either in the 5th week, in the 3rd or the 16th month of life for 6 consecutive days (test days 1-6), eight trials per day.
In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.
Report a problemFND-1021206304
05AnimalNot a test of Cerebrolysin aloneAnimal study (in vivo)Efficacy outcome
In young rats, the abstract reported no significant swimming speed differences for early treatment with Cerebrolysin or its fraction E021 versus saline.
In plain wordsIn young rats, Cerebrolysin or E021 treatment showed no significant swimming speed difference compared with saline.
Peptide
Cerebrolysin
Outcome
No significant changeSwimming speed in young rats across drug preparations
Study
ratn: not reported in source
Early postnatal treatment followed by Morris water maze testing
Comparator
Saline-treated controls
Outcome group
Exercise and physical function · Nervous system and cognition
Source sentences
Summary
No significant differences in the swimming speed were evaluated for the young rats
3 context sentences(design, population, supporting numbers)
Summary · context
In the present study the effects of early postnatal administration of Cerebrolysin (Cere, 10 mg/ml peptides) or an enriched peptide fraction of Cere (E021, 80.6 mg/ml peptides) were investigated in young, young adult, and old adult rats.
Summary · context
Rat pups received the drugs or saline for control on postnatal days 1-7.
Summary · context
The animals were tested in the Morris water maze (MWM) either in the 5th week, in the 3rd or the 16th month of life for 6 consecutive days (test days 1-6), eight trials per day.
In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.
Report a problemFND-1021206305
06AnimalNot a test of Cerebrolysin aloneAnimal study (in vivo)Efficacy outcome
In young adult rats, drug-treated animals receiving Cerebrolysin or E021 showed a moderate swimming speed increase versus saline controls.
In plain wordsIn young adult rats, animals treated with Cerebrolysin or E021 swam moderately faster than saline controls.
Peptide
Cerebrolysin
Outcome
IncreaseSwimming speed in young adult rats across drug preparations
Study
ratn: not reported in source
Early postnatal treatment followed by Morris water maze testing
Comparator
Saline-treated controls
Outcome group
Exercise and physical function · Nervous system and cognition
Source sentences
Summary
although in 3-month-old drug-tested animals a moderate increase of the swimming speed was investigated.
3 context sentences(design, population, supporting numbers)
Summary · context
In the present study the effects of early postnatal administration of Cerebrolysin (Cere, 10 mg/ml peptides) or an enriched peptide fraction of Cere (E021, 80.6 mg/ml peptides) were investigated in young, young adult, and old adult rats.
Summary · context
Rat pups received the drugs or saline for control on postnatal days 1-7.
Summary · context
The animals were tested in the Morris water maze (MWM) either in the 5th week, in the 3rd or the 16th month of life for 6 consecutive days (test days 1-6), eight trials per day.
In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.
Report a problemFND-1021206306
07AnimalNot a test of Cerebrolysin aloneAnimal study (in vivo)Efficacy outcome
In old adult rats, the abstract reported no significant escape latency differences for early Cerebrolysin or E021 treatment versus saline.
In plain wordsIn old adult rats, early Cerebrolysin or E021 treatment showed no significant maze escape time difference compared with saline.
Peptide
Cerebrolysin
Outcome
No significant changeEscape latency in old adult rats across drug preparations
Study
ratn: not reported in source
Early postnatal treatment followed by Morris water maze testing
Comparator
Saline-treated controls
Outcome group
Cognition and memory · Nervous system and cognition
Source sentences
Summary
For 16-month-old animals no significant differences in either escape latencies or swimming speed was found.
3 context sentences(design, population, supporting numbers)
Summary · context
In the present study the effects of early postnatal administration of Cerebrolysin (Cere, 10 mg/ml peptides) or an enriched peptide fraction of Cere (E021, 80.6 mg/ml peptides) were investigated in young, young adult, and old adult rats.
Summary · context
Rat pups received the drugs or saline for control on postnatal days 1-7.
Summary · context
The animals were tested in the Morris water maze (MWM) either in the 5th week, in the 3rd or the 16th month of life for 6 consecutive days (test days 1-6), eight trials per day.
In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.
Report a problemFND-1021206307
08AnimalNot a test of Cerebrolysin aloneAnimal study (in vivo)Efficacy outcome
In old adult rats, the abstract reported no significant swimming speed differences for early Cerebrolysin or E021 treatment versus saline.
In plain wordsIn old adult rats, early Cerebrolysin or E021 treatment showed no significant swimming speed difference compared with saline.
Peptide
Cerebrolysin
Outcome
No significant changeSwimming speed in old adult rats across drug preparations
Study
ratn: not reported in source
Early postnatal treatment followed by Morris water maze testing
Comparator
Saline-treated controls
Outcome group
Exercise and physical function · Nervous system and cognition
Source sentences
Summary
For 16-month-old animals no significant differences in either escape latencies or swimming speed was found.
3 context sentences(design, population, supporting numbers)
Summary · context
In the present study the effects of early postnatal administration of Cerebrolysin (Cere, 10 mg/ml peptides) or an enriched peptide fraction of Cere (E021, 80.6 mg/ml peptides) were investigated in young, young adult, and old adult rats.
Summary · context
Rat pups received the drugs or saline for control on postnatal days 1-7.
Summary · context
The animals were tested in the Morris water maze (MWM) either in the 5th week, in the 3rd or the 16th month of life for 6 consecutive days (test days 1-6), eight trials per day.
In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.
Report a problemFND-1021206308

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
14 Oct 2026, 05:02 UTC
Study results updated
Version 1
14 Oct 2026, 01:46 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

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