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Study · In vitro (cells) · 1999

2 results

Expression of insulin-like growth factor binding protein-3 (IGFBP-3) in human keratinocytes is regulated by EGF and TGFbeta1.

Edmondson SR, Murashita MM, Russo VC, Wraight CJ, Werther GA

Journal of cellular physiology1 May 1999Cited by 27 (Europe PMC)

PMID10199559 (opens in a new tab)DOI10.1002/(sici)1097-4652(199905)179:2<201::aid-jcp10>3.0.co;2-9 (opens in a new tab)PepBankPUB-10199559
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    Des(1‑3)IGF-I caused no consistent change in IGFBP-3 abundance in human keratinocyte cultures.

    In plain wordsIn cells, des(1‑3)IGF-I did not consistently change IGFBP-3 protein abundance.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    No significant changeIGFBP-3 abundance
    Study

    humann: not reported in source

    human keratinocytes
    Outcome group
    Skin and hair · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Treatment with IGF-I or its analogue des(1-3)IGF-I did not lead to any consistent change in IGFBP-3 abundance.
    1 context sentence
    Summary · context
    Here we examine the regulation of human keratinocyte-produced IGFBPs by epidermal growth factor (EGF), transforming growth factor beta 1 (TGFbeta1), and IGF-I, growth factors known to be active in skin.
  2. 02LabIn vitro (cells)Mechanism

    Des(1‑3)IGF-I at 100 ng/ml modestly increased IGFBP-3 mRNA in human keratinocytes.

    In plain wordsIn cells, des(1‑3)IGF-I modestly increased the genetic message for IGFBP-3.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    IncreaseIGFBP-3 mRNA
    Study

    humann: not reported in source

    human keratinocytes
    Outcome group
    Skin and hair · Skin and wound
    Studied dose
    100 ng/mlAs given in this study (human).

    Source sentences

    Summary
    However, both IGF-I and des(1-3)IGF-I at 100 ng/ml led to a modest increase in IGFBP-3 mRNA levels in keratinocytes, suggesting posttranscriptional regulation of IGFBP-3 abundance.
    1 context sentence
    Summary · context
    Here we examine the regulation of human keratinocyte-produced IGFBPs by epidermal growth factor (EGF), transforming growth factor beta 1 (TGFbeta1), and IGF-I, growth factors known to be active in skin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 2

    21 Oct 2026, 13:52 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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