Skip to content

Study · Animal study (in vivo) · rat · 1999

4 results

Clearance of IGFs and insulin from wounds: effect of IGF-binding protein interactions.

Robertson JG, Belford DA, Ballard FJ

The American journal of physiology1 Apr 1999Cited by 12 (Europe PMC)

PMID10198302 (opens in a new tab)DOI10.1152/ajpendo.1999.276.4.e663 (opens in a new tab)PepBankPUB-10198302
Publisher pagePubMedAsk about this study
Jump to 4 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Pharmacokinetics

    In rat wound chambers, LR3-IGF-I was cleared faster from wound fluid than IGF-I, with a half-life of 563 min versus 872 min.

    In plain wordsIn rats, an IGF-I analogue cleared from wound fluid faster than natural IGF-I.

    Peptide
    IGF-1 LR3
    Outcome
    DecreaseHalf-life in wound fluid
    Study

    ratn: not reported in source

    Subcutaneous Hunt-Schilling wound chambers
    Comparator
    IGF-I
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated

    Measurements

    Half-life
    563 min
    LR3-IGF-I in wound fluid

    Source sentences

    Summary
    However, LR3-IGF-I and insulin were cleared more rapidly from wound fluid than IGF-I so that the half-lives for IGF-I, IGF-II, LR3-IGF-I, and insulin were 872, 861, 563, and 324 min, respectively.
    1 context sentence
    Summary · context
    Hunt-Schilling chambers were subcutaneously implanted in rats, and the clearance of insulin-like growth factor (IGF) I from the chamber wound fluid was compared with IGF-II, LR3-IGF-I, which binds poorly to IGF-binding proteins (IGFBP), or insulin.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In rat wound chambers, LR3-IGF-I showed reduced association with wound fluid IGF-binding proteins.

    In plain wordsIn rats, an IGF-I analogue stuck less to binding proteins in wound fluid.

    Peptide
    IGF-1 LR3
    Outcome
    DecreaseAssociation with wound fluid IGF-binding proteins
    Study

    ratn: not reported in source

    Subcutaneous Hunt-Schilling wound chambers
    Comparator
    IGF-I
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    reduced association with wound fluid IGFBPs, and increased amounts of radioactivity of these peptides were detected in the circulation and urine.
    1 context sentence
    Summary · context
    Hunt-Schilling chambers were subcutaneously implanted in rats, and the clearance of insulin-like growth factor (IGF) I from the chamber wound fluid was compared with IGF-II, LR3-IGF-I, which binds poorly to IGF-binding proteins (IGFBP), or insulin.
  3. 03AnimalAnimal study (in vivo)Pharmacokinetics

    In rat wound chambers, more radioactivity from LR3-IGF-I than from IGF-I was detected in the circulation.

    In plain wordsIn rats, more of the IGF-I analogue than of natural IGF-I was found in the blood.

    Peptide
    IGF-1 LR3
    Outcome
    IncreaseRadioactivity in the circulation
    Study

    ratn: not reported in source

    Subcutaneous Hunt-Schilling wound chambers
    Comparator
    IGF-I
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    increased amounts of radioactivity of these peptides were detected in the circulation and urine.
    1 context sentence
    Summary · context
    Hunt-Schilling chambers were subcutaneously implanted in rats, and the clearance of insulin-like growth factor (IGF) I from the chamber wound fluid was compared with IGF-II, LR3-IGF-I, which binds poorly to IGF-binding proteins (IGFBP), or insulin.
  4. 04AnimalAnimal study (in vivo)Pharmacokinetics

    In rat wound chambers, more radioactivity from LR3-IGF-I than from IGF-I was detected in urine.

    In plain wordsIn rats, more of the IGF-I analogue than of natural IGF-I was found in urine.

    Peptide
    IGF-1 LR3
    Outcome
    IncreaseRadioactivity in urine
    Study

    ratn: not reported in source

    Subcutaneous Hunt-Schilling wound chambers
    Comparator
    IGF-I
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    increased amounts of radioactivity of these peptides were detected in the circulation and urine.
    1 context sentence
    Summary · context
    Hunt-Schilling chambers were subcutaneously implanted in rats, and the clearance of insulin-like growth factor (IGF) I from the chamber wound fluid was compared with IGF-II, LR3-IGF-I, which binds poorly to IGF-binding proteins (IGFBP), or insulin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

PepBank is a research reference. Talk to a doctor before you use any peptide.