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Study · Measured the body's own peptide · 1999

2 results

Oxytocin as a possible mediator of SSRI-induced antidepressant effects.

Uvnäs-Moberg K, Bjökstrand E, Hillegaart V, Ahlenius S

Psychopharmacology1 Feb 1999Cited by 99 (Europe PMC)

PMID10102788 (opens in a new tab)DOI10.1007/s002130050867 (opens in a new tab)PepBankPUB-10102788
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

No result from this study comes from a test of the peptide.

Natural levels measured2

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In adult male rats, acute citalopram increased the body's own plasma oxytocin levels.

    In plain wordsIn rats, a single dose of the antidepressant citalopram raised the body's own oxytocin level in blood.

    Peptide
    Oxytocin
    Outcome
    IncreasePlasma oxytocin after acute citalopram
    Study

    ratn: not reported in source

    Adult male Sprague-Dawley rats
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones

    Source sentences

    Summary
    Acute citalopram administration produced a statistically significant increase in plasma oxytocin and CCK levels.
    1 context sentence
    Summary · context
    Thus. in the present study we examined effects of the SSRI citalopram (20 mg/kg i.p.) on plasma oxytocin, acutely and upon repeated administration, in adult male Sprague-Dawley rats.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  2. 02AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In adult male rats, 14 days of citalopram did not reduce the oxytocin-releasing effect of a challenge dose of the SSRI zimeldine.

    In plain wordsIn rats, 14 days of citalopram did not weaken the rise in the body's own oxytocin after a second SSRI dose.

    Peptide
    Oxytocin
    Outcome
    No significant changePlasma oxytocin response to a zimeldine challenge after 14 days of citalopram
    Study

    ratn: not reported in source

    Adult male Sprague-Dawley rats
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones

    Source sentences

    Summary
    Administration of citalopram for 14 days did not attenuate the oxytocin-releasing effect to a challenge dose of the SSRI zimeldine (20 mg/kg s.c.)
    1 context sentence
    Summary · context
    Thus. in the present study we examined effects of the SSRI citalopram (20 mg/kg i.p.) on plasma oxytocin, acutely and upon repeated administration, in adult male Sprague-Dawley rats.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:51 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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