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Study · Animal study (in vivo) · rat · 1999

2 results

Vasoactive intestinal peptide suppresses migrating myoelectric complex of rat small intestine independent of nitric oxide.

Ljung T, Hellström PM

Acta physiologica Scandinavica1 Feb 1999Cited by 14 (Europe PMC)

PMID10090335 (opens in a new tab)DOI10.1046/j.1365-201x.1999.00497.x (opens in a new tab)PepBankPUB-10090335
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In rats, VIP infusion inhibited the small-bowel motility response, and L-NNA at 1 or 20 mg/kg did not change this response, so it did not depend on nitric oxide.

    In plain wordsIn rats, VIP slowed gut movement, and blocking nitric oxide did not change this effect.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    DecreaseVIP inhibition of small-bowel motility after NO synthase blockade
    Study

    ratn: not reported in source

    Outcome group
    Gastrointestinal protection · Gastrointestinal
    Studied dose
    500 pmol kg(-1) min(-1) · intravenous infusionAs given in this study (rat).

    Source sentences

    Summary
    Neither at 1 nor 20 mg kg(-1) did L-NNA affect the inhibitory motility response or decrease of blood pressure induced by VIP at a dose of 500 pmol kg(-1) min(-1).
    2 context sentences
    Summary · context
    Our results show that effects of VIP on motility of the small intestine and systemic arterial blood pressure are direct and not dependent on NO as a common final link.
    Summary · context
    In the second session, intravenous infusion of VIP 500 pmol kg(-1) min(-1) was administered before and after L-NNA at 1 and 20 mg kg(-1).
  2. 02AnimalAnimal study (in vivo)Mechanism

    In rats, VIP infusion lowered systemic arterial blood pressure, and L-NNA at 1 or 20 mg/kg did not change this fall, so it did not depend on nitric oxide.

    In plain wordsIn rats, VIP lowered blood pressure, and blocking nitric oxide did not change this effect.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    DecreaseVIP-induced fall in blood pressure after NO synthase blockade
    Study

    ratn: not reported in source

    Outcome group
    Blood pressure · Cardiovascular
    Studied dose
    500 pmol kg(-1) min(-1) · intravenous infusionAs given in this study (rat).

    Source sentences

    Summary
    Neither at 1 nor 20 mg kg(-1) did L-NNA affect the inhibitory motility response or decrease of blood pressure induced by VIP at a dose of 500 pmol kg(-1) min(-1).
    2 context sentences
    Summary · context
    Our results show that effects of VIP on motility of the small intestine and systemic arterial blood pressure are direct and not dependent on NO as a common final link.
    Summary · context
    In the second session, intravenous infusion of VIP 500 pmol kg(-1) min(-1) was administered before and after L-NNA at 1 and 20 mg kg(-1).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 12:58 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 12:41 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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