Restoration of emotional stress reactions in rats following disruption of the limbic structures of the brain by delta-sleep-inducing peptide.

Koplik EV, Sudakov KV

Neuroscience and behavioral physiology1 Jan 1999Cited by 1 (Europe PMC)

PMID10088149DOI10.1007/bf02461357PepBankPUB-10088149

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In male Wistar rats with lesions of the septum or amygdala, DSIP increased resistance to emotional stress.
In plain wordsIn rats with brain lesions, DSIP raised resistance to emotional stress.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
IncreaseResistance to emotional stress in lesioned animals
Study
ratn: not reported in source
male Wistar rats with septum or amygdala lesions under emotional stress
Outcome group
Anxiety and mood · Mental health and mood
Studied dose
60 nmol/kg · intraperitonealAs given in this study (rat).
Source sentences
Summary
Administration of peptide to animals with lesions to the septum or amygdala increased their resistance to emotional stress, as indicated by open field test behavior, survival, and adrenal and thymus weight in stress conditions.
3 context sentences(design, population, supporting numbers)
Summary · context
Studies were performed in male Wistar rats.
Summary · context
Peptide was given i.p. at a dose of 60 nmol/kg.
Summary · context
Bilateral lesioning to brain structures was carried out by anodic polarization.
Report a problemFND-1008814901
02AnimalAnimal study (in vivo)Efficacy outcome
In male Wistar rats with lesions of the septum or amygdala, DSIP improved stress resistance as indicated by open field test behavior.
In plain wordsIn rats with brain lesions, DSIP improved stress resistance as shown by open field test behavior.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
Direction not reportedOpen field behavior in lesioned animals under stress
Study
ratn: not reported in source
male Wistar rats with septum or amygdala lesions under emotional stress
Outcome group
Anxiety and mood · Mental health and mood
Studied dose
60 nmol/kg · intraperitonealAs given in this study (rat).
Source sentences
Summary
Administration of peptide to animals with lesions to the septum or amygdala increased their resistance to emotional stress, as indicated by open field test behavior, survival, and adrenal and thymus weight in stress conditions.
3 context sentences(design, population, supporting numbers)
Summary · context
Studies were performed in male Wistar rats.
Summary · context
Peptide was given i.p. at a dose of 60 nmol/kg.
Summary · context
Bilateral lesioning to brain structures was carried out by anodic polarization.
Report a problemFND-1008814902
03AnimalAnimal study (in vivo)Efficacy outcome
In male Wistar rats with lesions of the septum or amygdala, DSIP increased stress resistance as indicated by survival.
In plain wordsIn rats with brain lesions, DSIP improved survival under emotional stress.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
IncreaseSurvival under emotional stress in lesioned animals
Study
ratn: not reported in source
male Wistar rats with septum or amygdala lesions under emotional stress
Outcome group
Anxiety and mood · Mental health and mood
Studied dose
60 nmol/kg · intraperitonealAs given in this study (rat).
Source sentences
Summary
Administration of peptide to animals with lesions to the septum or amygdala increased their resistance to emotional stress, as indicated by open field test behavior, survival, and adrenal and thymus weight in stress conditions.
3 context sentences(design, population, supporting numbers)
Summary · context
Studies were performed in male Wistar rats.
Summary · context
Peptide was given i.p. at a dose of 60 nmol/kg.
Summary · context
Bilateral lesioning to brain structures was carried out by anodic polarization.
Report a problemFND-1008814903
04AnimalAnimal study (in vivo)Efficacy outcome
In male Wistar rats with lesions of the septum or amygdala, DSIP increased stress resistance as indicated by adrenal weight under stress.
In plain wordsIn rats with brain lesions, DSIP improved stress resistance as shown by adrenal weight under stress.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
Direction not reportedAdrenal weight under stress in lesioned animals
Study
ratn: not reported in source
male Wistar rats with septum or amygdala lesions under emotional stress
Outcome group
Anxiety and mood · Mental health and mood
Studied dose
60 nmol/kg · intraperitonealAs given in this study (rat).
Source sentences
Summary
Administration of peptide to animals with lesions to the septum or amygdala increased their resistance to emotional stress, as indicated by open field test behavior, survival, and adrenal and thymus weight in stress conditions.
3 context sentences(design, population, supporting numbers)
Summary · context
Studies were performed in male Wistar rats.
Summary · context
Peptide was given i.p. at a dose of 60 nmol/kg.
Summary · context
Bilateral lesioning to brain structures was carried out by anodic polarization.
Report a problemFND-1008814904
05AnimalAnimal study (in vivo)Efficacy outcome
In male Wistar rats with lesions of the septum or amygdala, DSIP increased stress resistance as indicated by thymus weight under stress.
In plain wordsIn rats with brain lesions, DSIP improved stress resistance as shown by thymus weight under stress.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
Direction not reportedThymus weight under stress in lesioned animals
Study
ratn: not reported in source
male Wistar rats with septum or amygdala lesions under emotional stress
Outcome group
Anxiety and mood · Mental health and mood
Studied dose
60 nmol/kg · intraperitonealAs given in this study (rat).
Source sentences
Summary
Administration of peptide to animals with lesions to the septum or amygdala increased their resistance to emotional stress, as indicated by open field test behavior, survival, and adrenal and thymus weight in stress conditions.
3 context sentences(design, population, supporting numbers)
Summary · context
Studies were performed in male Wistar rats.
Summary · context
Peptide was given i.p. at a dose of 60 nmol/kg.
Summary · context
Bilateral lesioning to brain structures was carried out by anodic polarization.
Report a problemFND-1008814905

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
10 Oct 2026, 08:55 UTC
Study results updated
Version 1
9 Oct 2026, 03:04 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

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