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Study · Measured the body's own peptide · 1999

3 results

Expression of insulin growth factor-1 splice variants and structural genes in rabbit skeletal muscle induced by stretch and stimulation.

McKoy G, Ashley W, Mander J, Yang SY, Williams N, Russell B, Goldspink G

The Journal of physiology1 Apr 1999Cited by 191 (Europe PMC)

PMID10087355 (opens in a new tab)DOI10.1111/j.1469-7793.1999.0583v.x (opens in a new tab)PepBankPUB-10087355
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Natural levels measured3

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In rabbit extensor digitorum longus muscle, stretch by plaster cast immobilization markedly upregulated both IGF-1 mRNA forms, including MGF, within 4 days.

    In plain wordsIn rabbits, stretching a muscle raised the body's own MGF and the other IGF-1 mRNA within 4 days.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseIGF-1 mRNA (including MGF) after stretch
    Study

    rabbitn: not reported in source

    extensor digitorum longus muscle under stretch and electrical stimulation
    Outcome group
    Muscle injury and repair · Musculoskeletal

    Source sentences

    Summary
    Within 4 days, stretch using plaster cast immobilization with the limb in the plantar flexed position resulted in marked upregulation of both forms of IGF-1 mRNA.
    1 context sentence
    Summary · context
    Using RNase protection assays with a probe that distinguishes these differently spliced forms of IGF-1, their expression and also the expression of two structural genes was measured in rabbit extensor digitorum longus muscles subjected to different mechanical signals.

    This result measures the body's own MGF / PEG-MGF. Nobody was given the peptide. It is not evidence about taking it.

  2. 02AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In rabbit extensor digitorum longus muscle, 10 Hz electrical stimulation combined with stretch gave an even greater increase of both IGF-1 transcripts, including MGF.

    In plain wordsIn rabbits, stretch plus electrical stimulation raised the body's own MGF mRNA even more than stretch alone.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseIGF-1 mRNA (including MGF) after stretch plus 10 Hz stimulation
    Study

    rabbitn: not reported in source

    extensor digitorum longus muscle under stretch and electrical stimulation
    Comparator
    Stretch alone
    Outcome group
    Muscle injury and repair · Musculoskeletal

    Source sentences

    Summary
    Electrical stimulation at 10 Hz combined with stretch (overload) resulted in an even greater increase of both types of IGF-1 transcript
    1 context sentence
    Summary · context
    Using RNase protection assays with a probe that distinguishes these differently spliced forms of IGF-1, their expression and also the expression of two structural genes was measured in rabbit extensor digitorum longus muscles subjected to different mechanical signals.

    This result measures the body's own MGF / PEG-MGF. Nobody was given the peptide. It is not evidence about taking it.

  3. 03AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In rabbit extensor digitorum longus muscle, electrical stimulation alone without stretch did not significantly increase IGF-1 transcripts, including MGF, over sham-operated controls.

    In plain wordsIn rabbits, electrical stimulation alone did not significantly raise the body's own MGF mRNA compared with sham controls.

    Peptide
    MGF / PEG-MGF
    Outcome
    No significant changeIGF-1 mRNA (including MGF) after electrical stimulation alone
    Study

    rabbitn: not reported in source

    extensor digitorum longus muscle under stretch and electrical stimulation
    Comparator
    Sham-operated controls
    Outcome group
    Muscle injury and repair · Musculoskeletal

    Source sentences

    Summary
    electrical stimulation alone, i.e. without stretch, resulted in no significant increase over muscle from sham-operated controls.
    1 context sentence
    Summary · context
    Using RNase protection assays with a probe that distinguishes these differently spliced forms of IGF-1, their expression and also the expression of two structural genes was measured in rabbit extensor digitorum longus muscles subjected to different mechanical signals.

    This result measures the body's own MGF / PEG-MGF. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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