Effects of NGF, b-FGF, and cerebrolysin on water maze performance and on motor activity of rats: short- and long-term study.

Valousková V, Gschanes A

Neurobiology of learning and memory1 Mar 1999Cited by 17 (Europe PMC)

PMID10082636DOI10.1006/nlme.1998.3877PepBankPUB-10082636

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In rats with cortical lesions, Cerebrolysin-treated rats performed the early water maze task at the level of nonlesioned controls.
In plain wordsIn rats with cortical lesions, Cerebrolysin-treated rats matched nonlesioned controls on the early water maze task.
Peptide
Cerebrolysin
Outcome
No significant changeEarly water maze performance versus nonlesioned controls
Study
ratn: not reported in source
Bilateral frontoparietal sensorimotor cortex lesion
Comparator
Nonlesioned controls
Outcome group
Cognition and memory · Nervous system and cognition
Studied dose
Dose not stated · 14 daysAs given in this study (rat).
Source sentences
Summary
Only the rats treated with Cerebrolysin performed the water maze task at the level of the nonlesioned controls in the early test.
2 context sentences(design, population, supporting numbers)
Summary · context
The effects of 14-day treatments with nerve growth factor (NGF), basic fibroblast growth factor (b-FGF), or the peptidergic drug Cerebrolysin on postlesion acquisition of a water maze task and on motor activity were evaluated.
Summary · context
Rats were tested in the Morris water maze 14 days (early test) and 7 to 8 months (delayed test) after a bilateral lesion of the frontoparietal (sensorimotor) cortex.
Report a problemFND-1008263601
02AnimalAnimal study (in vivo)Efficacy outcome
In rats with cortical lesions, Cerebrolysin attenuated the early water maze acquisition deficit.
In plain wordsIn rats with cortical lesions, Cerebrolysin reduced the early deficit in learning the water maze.
Peptide
Cerebrolysin
Outcome
DecreaseEarly water maze acquisition deficit
Study
ratn: not reported in source
Bilateral frontoparietal sensorimotor cortex lesion
Outcome group
Cognition and memory · Nervous system and cognition
Studied dose
Dose not stated · 14 daysAs given in this study (rat).
Source sentences
Summary
Two-week administration of Cerebrolysin had a time-dependent influence: it attenuated the acquisition deficit and increased the motor activity of rats, both effects declined to the level of lesioned controls within 8 months.
2 context sentences(design, population, supporting numbers)
Summary · context
The effects of 14-day treatments with nerve growth factor (NGF), basic fibroblast growth factor (b-FGF), or the peptidergic drug Cerebrolysin on postlesion acquisition of a water maze task and on motor activity were evaluated.
Summary · context
Rats were tested in the Morris water maze 14 days (early test) and 7 to 8 months (delayed test) after a bilateral lesion of the frontoparietal (sensorimotor) cortex.
Report a problemFND-1008263602
03AnimalAnimal study (in vivo)Efficacy outcome
In rats with cortical lesions, Cerebrolysin increased motor activity after two-week administration.
In plain wordsIn rats with cortical lesions, Cerebrolysin increased motor activity after treatment.
Peptide
Cerebrolysin
Outcome
IncreaseEarly motor activity
Study
ratn: not reported in source
Bilateral frontoparietal sensorimotor cortex lesion
Outcome group
Exercise and physical function · Nervous system and cognition
Studied dose
Dose not stated · 14 daysAs given in this study (rat).
Source sentences
Summary
Two-week administration of Cerebrolysin had a time-dependent influence: it attenuated the acquisition deficit and increased the motor activity of rats, both effects declined to the level of lesioned controls within 8 months.
2 context sentences(design, population, supporting numbers)
Summary · context
The effects of 14-day treatments with nerve growth factor (NGF), basic fibroblast growth factor (b-FGF), or the peptidergic drug Cerebrolysin on postlesion acquisition of a water maze task and on motor activity were evaluated.
Summary · context
Rats were tested in the Morris water maze 14 days (early test) and 7 to 8 months (delayed test) after a bilateral lesion of the frontoparietal (sensorimotor) cortex.
Report a problemFND-1008263603
04AnimalAnimal study (in vivo)Efficacy outcome
In rats with cortical lesions, Cerebrolysin's water maze benefit declined to the level of lesioned controls within 8 months.
In plain wordsIn rats with cortical lesions, Cerebrolysin's maze learning benefit declined to the level of lesioned controls within 8 months.
Peptide
Cerebrolysin
Outcome
No significant changeDelayed water maze acquisition
Study
ratn: not reported in source
Bilateral frontoparietal sensorimotor cortex lesion
Comparator
Lesioned controls
Outcome group
Cognition and memory · Nervous system and cognition
Studied dose
Dose not stated · 14 daysAs given in this study (rat).
Source sentences
Summary
Two-week administration of Cerebrolysin had a time-dependent influence: it attenuated the acquisition deficit and increased the motor activity of rats, both effects declined to the level of lesioned controls within 8 months.
2 context sentences(design, population, supporting numbers)
Summary · context
The effects of 14-day treatments with nerve growth factor (NGF), basic fibroblast growth factor (b-FGF), or the peptidergic drug Cerebrolysin on postlesion acquisition of a water maze task and on motor activity were evaluated.
Summary · context
Rats were tested in the Morris water maze 14 days (early test) and 7 to 8 months (delayed test) after a bilateral lesion of the frontoparietal (sensorimotor) cortex.
Report a problemFND-1008263604
05AnimalAnimal study (in vivo)Efficacy outcome
In rats with cortical lesions, Cerebrolysin's motor activity effect declined to the level of lesioned controls within 8 months.
In plain wordsIn rats with cortical lesions, Cerebrolysin's motor activity effect declined to the level of lesioned controls within 8 months.
Peptide
Cerebrolysin
Outcome
No significant changeDelayed motor activity
Study
ratn: not reported in source
Bilateral frontoparietal sensorimotor cortex lesion
Comparator
Lesioned controls
Outcome group
Exercise and physical function · Nervous system and cognition
Studied dose
Dose not stated · 14 daysAs given in this study (rat).
Source sentences
Summary
Two-week administration of Cerebrolysin had a time-dependent influence: it attenuated the acquisition deficit and increased the motor activity of rats, both effects declined to the level of lesioned controls within 8 months.
2 context sentences(design, population, supporting numbers)
Summary · context
The effects of 14-day treatments with nerve growth factor (NGF), basic fibroblast growth factor (b-FGF), or the peptidergic drug Cerebrolysin on postlesion acquisition of a water maze task and on motor activity were evaluated.
Summary · context
Rats were tested in the Morris water maze 14 days (early test) and 7 to 8 months (delayed test) after a bilateral lesion of the frontoparietal (sensorimotor) cortex.
Report a problemFND-1008263605

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
14 Oct 2026, 05:02 UTC
Study results updated
Version 1
14 Oct 2026, 01:46 UTC
First added · source update from Europe PMC

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