Oral administration of peptidergic growth hormone (GH) secretagogue KP102 stimulates GH release in goats.

Hashizume T, Kawai M, Ohtsuki K, Ishii A, Numata M

Domestic animal endocrinology1 Jan 1999Cited by 6 (Europe PMC)

PMID10081661DOI10.1016/s0739-7240(98)00048-4PepBankPUB-10081661

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study10

10 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Activity measurement
In 1-month-old goats, oral KP102 (GHRP‑2) at 5 and 10 mg/kg raised plasma GH at 15 minutes after the first dose.
In plain wordsIn young goats, oral KP102 raised growth hormone in the blood within 15 minutes.
Peptide
GHRP-2
Outcome
IncreasePlasma GH in 1-month-old goats after first dose
Study
goatn: not reported in source
in vivo
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
5 and 10 mg/kg BW · oral · two doses 2 hours apartAs given in this study (goat).
Source sentences
Summary
Plasma GH concentrations in the 1-mo-old goats were elevated at 15 min after the first administration of both 5 and 10 mg/kg BW of KP102.
1 context sentence(design, population, supporting numbers)
Summary · context
To assess the oral activity of KP102 (also known GHRP-2) on growth hormone (GH) release in ruminant animals, 5 or 10 mg/kg body weight (BW) of KP102 dissolved in saline was orally administered twice at 2 hr-intervals to either 1- or 3-mo-old goats (n = 5-6).
Report a problemFND-1008166101
02AnimalAnimal study (in vivo)Activity measurement
In 1-month-old goats, GH stayed significantly elevated until 180 minutes after 10 mg/kg of oral KP102.
In plain wordsIn young goats, a 10 mg/kg dose of KP102 kept growth hormone raised for up to 180 minutes.
Peptide
GHRP-2
Outcome
IncreaseDuration of GH elevation at 10 mg/kg in 1-month-old goats
Study
goatn: not reported in source
in vivo
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
10 mg/kg BW · oral · two doses 2 hours apartAs given in this study (goat).
Source sentences
Summary
Significant elevation of GH concentrations continued until 180 min after 10 mg/kg BW of KP102, whereas the elevated GH levels after the administrations of 5 mg/kg BW of KP102 subsided to basal concentrations within 90 min.
1 context sentence(design, population, supporting numbers)
Summary · context
To assess the oral activity of KP102 (also known GHRP-2) on growth hormone (GH) release in ruminant animals, 5 or 10 mg/kg body weight (BW) of KP102 dissolved in saline was orally administered twice at 2 hr-intervals to either 1- or 3-mo-old goats (n = 5-6).
Report a problemFND-1008166102
03AnimalAnimal study (in vivo)Activity measurement
In 1-month-old goats, GH raised by 5 mg/kg of oral KP102 returned to basal levels within 90 minutes.
In plain wordsIn young goats, a 5 mg/kg dose of KP102 raised growth hormone only for under 90 minutes.
Peptide
GHRP-2
Outcome
IncreaseDuration of GH elevation at 5 mg/kg in 1-month-old goats
Study
goatn: not reported in source
in vivo
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
5 mg/kg BW · oral · two doses 2 hours apartAs given in this study (goat).
Source sentences
Summary
Significant elevation of GH concentrations continued until 180 min after 10 mg/kg BW of KP102, whereas the elevated GH levels after the administrations of 5 mg/kg BW of KP102 subsided to basal concentrations within 90 min.
1 context sentence(design, population, supporting numbers)
Summary · context
To assess the oral activity of KP102 (also known GHRP-2) on growth hormone (GH) release in ruminant animals, 5 or 10 mg/kg body weight (BW) of KP102 dissolved in saline was orally administered twice at 2 hr-intervals to either 1- or 3-mo-old goats (n = 5-6).
Report a problemFND-1008166103
04AnimalAnimal study (in vivo)Activity measurement
In 1-month-old goats, the second 10 mg/kg dose of oral KP102 failed to raise GH.
In plain wordsIn young goats, a second 10 mg/kg dose of KP102 did not raise growth hormone again.
Peptide
GHRP-2
Outcome
No significant changeGH after second 10 mg/kg dose in 1-month-old goats
Study
goatn: not reported in source
in vivo
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
10 mg/kg BW · oral · two doses 2 hours apartAs given in this study (goat).
Source sentences
Summary
The second administration of 10 mg/kg BW of KP102 failed to elevate the GH concentration, but 5 mg/kg BW of KP102 abruptly stimulated GH release.
1 context sentence(design, population, supporting numbers)
Summary · context
To assess the oral activity of KP102 (also known GHRP-2) on growth hormone (GH) release in ruminant animals, 5 or 10 mg/kg body weight (BW) of KP102 dissolved in saline was orally administered twice at 2 hr-intervals to either 1- or 3-mo-old goats (n = 5-6).
Report a problemFND-1008166104
05AnimalAnimal study (in vivo)Activity measurement
In 1-month-old goats, the second 5 mg/kg dose of oral KP102 abruptly stimulated GH release.
In plain wordsIn young goats, a second 5 mg/kg dose of KP102 raised growth hormone again.
Peptide
GHRP-2
Outcome
IncreaseGH after second 5 mg/kg dose in 1-month-old goats
Study
goatn: not reported in source
in vivo
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
5 mg/kg BW · oral · two doses 2 hours apartAs given in this study (goat).
Source sentences
Summary
The second administration of 10 mg/kg BW of KP102 failed to elevate the GH concentration, but 5 mg/kg BW of KP102 abruptly stimulated GH release.
1 context sentence(design, population, supporting numbers)
Summary · context
To assess the oral activity of KP102 (also known GHRP-2) on growth hormone (GH) release in ruminant animals, 5 or 10 mg/kg body weight (BW) of KP102 dissolved in saline was orally administered twice at 2 hr-intervals to either 1- or 3-mo-old goats (n = 5-6).
Report a problemFND-1008166105
06AnimalAnimal study (in vivo)Activity measurement
In 3-month-old goats, oral KP102 at 5 and 10 mg/kg significantly raised plasma GH.
In plain wordsIn goats aged 3 months, oral KP102 raised growth hormone in the blood at both doses.
Peptide
GHRP-2
Outcome
IncreasePlasma GH in 3-month-old goats
Study
goatn: not reported in source
in vivo
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
5 and 10 mg/kg BW · oral · two doses 2 hours apartAs given in this study (goat).
Source sentences
Summary
Plasma GH concentrations in the 3-mo-old goats were also significantly elevated after the administration of both 5 and 10 mg/kg BW of KP102.
1 context sentence(design, population, supporting numbers)
Summary · context
To assess the oral activity of KP102 (also known GHRP-2) on growth hormone (GH) release in ruminant animals, 5 or 10 mg/kg body weight (BW) of KP102 dissolved in saline was orally administered twice at 2 hr-intervals to either 1- or 3-mo-old goats (n = 5-6).
Report a problemFND-1008166106
07AnimalAnimal study (in vivo)Activity measurement
In 3-month-old goats, the plasma GH responses to 5 and 10 mg/kg of KP102 were almost identical.
In plain wordsIn goats aged 3 months, the 5 and 10 mg/kg doses of KP102 gave almost the same growth hormone response.
Peptide
GHRP-2
Outcome
No significant changeDose comparison of GH response in 3-month-old goats
Study
goatn: not reported in source
in vivo
Comparator
5 mg/kg versus 10 mg/kg
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
5 and 10 mg/kg BW · oral · two doses 2 hours apartAs given in this study (goat).
Source sentences
Summary
The plasma GH responses to 5 and 10 mg/kg BW of KP102 were almost identical.
1 context sentence(design, population, supporting numbers)
Summary · context
To assess the oral activity of KP102 (also known GHRP-2) on growth hormone (GH) release in ruminant animals, 5 or 10 mg/kg body weight (BW) of KP102 dissolved in saline was orally administered twice at 2 hr-intervals to either 1- or 3-mo-old goats (n = 5-6).
Report a problemFND-1008166107
08AnimalAnimal study (in vivo)Activity measurement
In 3-month-old goats, GH levels after the first KP102 dose tended to stay elevated, with a transient rise after the second dose.
In plain wordsIn goats aged 3 months, growth hormone stayed raised after the first KP102 dose and rose briefly after the second.
Peptide
GHRP-2
Outcome
IncreaseTime course of GH in 3-month-old goats
Study
goatn: not reported in source
in vivo
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
5 and 10 mg/kg BW · oral · two doses 2 hours apartAs given in this study (goat).
Source sentences
Summary
The elevated GH levels after the first administration of KP102 tended to be maintained throughout the experiment, and a transient increase in plasma GH levels was observed after the second administration.
1 context sentence(design, population, supporting numbers)
Summary · context
To assess the oral activity of KP102 (also known GHRP-2) on growth hormone (GH) release in ruminant animals, 5 or 10 mg/kg body weight (BW) of KP102 dissolved in saline was orally administered twice at 2 hr-intervals to either 1- or 3-mo-old goats (n = 5-6).
Report a problemFND-1008166108
09AnimalAnimal study (in vivo)Activity measurement
In goats, the stimulatory effect of KP102 on GH release was smaller and less abrupt at 3 months than at 1 month.
In plain wordsIn goats, KP102 raised growth hormone less in 3-month-old animals than in 1-month-old animals.
Peptide
GHRP-2
Outcome
DecreaseGH response in 3-month-old versus 1-month-old goats
Study
goatn: not reported in source
in vivo
Comparator
1-month-old goats
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
5 and 10 mg/kg BW · oral · two doses 2 hours apartAs given in this study (goat).
Source sentences
Summary
However, the stimulatory effect of KP102 on GH release in the 3-mo-old goats was small and less abrupt than that in the 1-mo-old goats.
1 context sentence(design, population, supporting numbers)
Summary · context
To assess the oral activity of KP102 (also known GHRP-2) on growth hormone (GH) release in ruminant animals, 5 or 10 mg/kg body weight (BW) of KP102 dissolved in saline was orally administered twice at 2 hr-intervals to either 1- or 3-mo-old goats (n = 5-6).
Report a problemFND-1008166109
10AnimalAnimal study (in vivo)Activity measurement
In goats, IGF-I concentrations were not increased by KP102 during the brief sampling periods.
In plain wordsIn goats, KP102 did not raise IGF-I during the short sampling period.
Peptide
GHRP-2
Outcome
No significant changePlasma IGF-I concentration
Study
goatn: not reported in source
in vivo
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
5 and 10 mg/kg BW · oral · two doses 2 hours apartAs given in this study (goat).
Source sentences
Summary
The concentrations of insulin-like growth factor-I were not increased by KP102 during the brief sampling periods used in this experiment.
1 context sentence(design, population, supporting numbers)
Summary · context
To assess the oral activity of KP102 (also known GHRP-2) on growth hormone (GH) release in ruminant animals, 5 or 10 mg/kg body weight (BW) of KP102 dissolved in saline was orally administered twice at 2 hr-intervals to either 1- or 3-mo-old goats (n = 5-6).
Report a problemFND-1008166110

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 21:44 UTC
Study results updated
Version 1
13 Oct 2026, 16:31 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

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