Study · Animal study (in vivo) · western scrub-jay, white-crowned sparrow and dark-eyed junco · 1999

4 results

Effects of vasoactive intestinal peptide on plasma prolactin in passerines.

Maney DL, Schoech SJ, Sharp PJ, Wingfield JC

General and comparative endocrinology1 Mar 1999Cited by 40 (Europe PMC)

PMID10068494DOI10.1006/gcen.1998.7220PepBankPUB-10068494

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In breeding-season white-crowned sparrows, dark-eyed juncos and Florida scrub-jays, intravenous VIP rapidly increased plasma prolactin.
In plain wordsIn three bird species tested in the breeding season, VIP quickly raised blood prolactin.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
IncreasePlasma prolactin after VIP in breeding-season sparrow, junco and Florida scrub-jay
Study
white-crowned sparrow, dark-eyed junco, Florida scrub-jayn: not reported in source
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
Dose not stated · intravenousAs given in this study (white-crowned sparrow, dark-eyed junco, Florida scrub-jay).
Source sentences
Summary
In the white-crowned sparrow, junco, and Florida scrub-jay, which were tested during the breeding season, VIP induced a rapid increase in plasma PRL.
1 context sentence(design, population, supporting numbers)
Summary · context
We tested the effects of intravenously administered chicken VIP on plasma PRL concentrations in four passerine species: the white-crowned sparrow (Zonotrichia leucophrys gambelii), the dark-eyed junco (Junco hyemalis), the Florida scrub-jay (Aphelocoma coerulescens), and the western scrub-jay (A. californica).
Report a problemFND-1006849401
02AnimalAnimal study (in vivo)Efficacy outcome
In white-crowned sparrows, plasma prolactin rose 10-fold within 2 min of VIP injection and then declined gradually.
In plain wordsIn white-crowned sparrows, VIP raised blood prolactin 10-fold within 2 minutes, then it fell slowly.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
IncreasePlasma prolactin time course after VIP in white-crowned sparrow
Study
white-crowned sparrown: not reported in source
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
Dose not stated · intravenousAs given in this study (white-crowned sparrow).
Measurements
Prolactin increase
10-fold
white-crowned sparrow, within 2 min
Source sentences
Summary
Serial plasma samples taken after VIP injection in the white-crowned sparrow show a 10-fold increase in PRL within 2 min of treatment, followed by a gradual decline.
1 context sentence(design, population, supporting numbers)
Summary · context
We tested the effects of intravenously administered chicken VIP on plasma PRL concentrations in four passerine species: the white-crowned sparrow (Zonotrichia leucophrys gambelii), the dark-eyed junco (Junco hyemalis), the Florida scrub-jay (Aphelocoma coerulescens), and the western scrub-jay (A. californica).
Report a problemFND-1006849402
03AnimalAnimal study (in vivo)Efficacy outcome
In white-crowned sparrows, the VIP effect on plasma prolactin stayed significant versus saline for at least 20 min after treatment.
In plain wordsIn white-crowned sparrows, VIP kept prolactin higher than saline did for at least 20 minutes.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
IncreasePlasma prolactin after VIP versus saline over 20 min
Study
white-crowned sparrown: not reported in source
Comparator
Saline
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
Dose not stated · intravenousAs given in this study (white-crowned sparrow).
Measurements
Duration of significant effect
≥ 20 min
versus saline
Source sentences
Summary
Effects of VIP, as compared to saline, remained significant for at least 20 min after treatment.
1 context sentence(design, population, supporting numbers)
Summary · context
We tested the effects of intravenously administered chicken VIP on plasma PRL concentrations in four passerine species: the white-crowned sparrow (Zonotrichia leucophrys gambelii), the dark-eyed junco (Junco hyemalis), the Florida scrub-jay (Aphelocoma coerulescens), and the western scrub-jay (A. californica).
Report a problemFND-1006849403
04AnimalAnimal study (in vivo)Efficacy outcome
In western scrub-jays tested after the breeding season, intravenous VIP did not significantly raise plasma prolactin.
In plain wordsIn western scrub-jays tested after breeding, VIP did not significantly raise blood prolactin.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
No significant changePlasma prolactin after VIP in western scrub-jay (non-breeding)
Study
western scrub-jayn: not reported in source
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
Dose not stated · intravenousAs given in this study (western scrub-jay).
Source sentences
Summary
Western scrub-jays did not respond to intravenous VIP with a significant rise in PRL secretion, possibly because they were tested after termination of the breeding season.
1 context sentence(design, population, supporting numbers)
Summary · context
We tested the effects of intravenously administered chicken VIP on plasma PRL concentrations in four passerine species: the white-crowned sparrow (Zonotrichia leucophrys gambelii), the dark-eyed junco (Junco hyemalis), the Florida scrub-jay (Aphelocoma coerulescens), and the western scrub-jay (A. californica).
Report a problemFND-1006849404

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
12 Oct 2026, 12:58 UTC
Study results updated
Version 1
9 Oct 2026, 12:41 UTC
First added · source update from Europe PMC

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