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Study · In vitro (cells) · pig · 1999

2 results

Effect of insulin-like growth factor (IGF)-I and Des (1-3) IGF-I on the level of IGF binding protein-3 and IGF binding protein-3 mRNA in cultured porcine embryonic muscle cells.

Yang F, Johnson BJ, White ME, Hathaway MR, Dayton WR

Journal of cellular physiology1 Feb 1999Cited by 19 (Europe PMC)

PMID10048587 (opens in a new tab)DOI10.1002/(sici)1097-4652(199902)178:2<227::aid-jcp12>3.0.co;2-w (opens in a new tab)PepBankPUB-10048587
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    Des (1-3) IGF-I treatment reduced conditioned-medium IGFBP-3 threefold in porcine myogenic cultures.

    In plain wordsIn cells from pigs, des (1-3) IGF-I reduced IGFBP-3 protein in the surrounding culture medium.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    DecreaseConditioned-medium IGFBP-3
    Study

    pign: not reported in source

    embryonic porcine myogenic cultures
    Outcome group
    Muscle injury and repair · Musculoskeletal
    Studied dose
    20 ng/ml · 24 hAs given in this study (pig).

    Measurements

    IGFBP-3 reduction
    3 fold
    conditioned media after Des (1-3) IGF-I treatment

    Source sentences

    Summary
    Treatment of porcine myogenic cultures with 20 ng of IGF-I or 20 ng of Des (1-3) IGF-I/ml serum-free media for 24 h results in a threefold reduction in the level of IGFBP-3 in conditioned media.

Studies that did not test the peptide alone1

In this study, IGF-1 DES (des(1-3)IGF-I) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking IGF-1 DES (des(1-3)IGF-I).

  1. 02LabNot a test of IGF-1 DES (des(1-3)IGF-I) aloneIn vitro (cells)Mechanism

    Cell density over a sixfold range did not affect the IGFBP-3 reduction after Des (1-3) IGF-I treatment.

    In plain wordsIn cells from pigs, different cell densities did not change the IGFBP-3 reduction after des (1-3) IGF-I treatment.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    No significant changeCell-density dependence of IGFBP-3 reduction
    Study

    pign: not reported in source

    embryonic porcine myogenic cultures
    Comparator
    cell densities over a sixfold range
    Outcome group
    Muscle injury and repair · Musculoskeletal

    Source sentences

    Summary
    This reduction is not affected by cell density over a sixfold range.
    1 context sentence
    Summary · context
    Treatment of porcine myogenic cultures with 20 ng of IGF-I or 20 ng of Des (1-3) IGF-I/ml serum-free media for 24 h results in a threefold reduction in the level of IGFBP-3 in conditioned media.

    In this study, IGF-1 DES (des(1-3)IGF-I) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking IGF-1 DES (des(1-3)IGF-I).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 2

    21 Oct 2026, 13:52 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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