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Study · Not a test of the peptide alone · 1999

6 results

Induction of puberty with human chorionic gonadotropin and follicle-stimulating hormone in adolescent males with hypogonadotropic hypogonadism.

Barrio R, de Luis D, Alonso M, Lamas A, Moreno JC

Fertility and sterility1 Feb 1999Cited by 55 (Europe PMC)

PMID9988392 (opens in a new tab)DOI10.1016/s0015-0282(98)00450-6 (opens in a new tab)PepBankPUB-09988392
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone6

In this study, hCG (human chorionic gonadotropin) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking hCG (human chorionic gonadotropin).

  1. 01HumanNot a test of hCG (human chorionic gonadotropin) aloneNon-randomized trialEfficacy outcome

    In adolescent males with hypogonadotropic hypogonadism, combined hCG and FSH produced normal sexual maturation in all patients.

    In plain wordsIn adolescent males with hypogonadotropic hypogonadism, combined hCG and FSH produced normal sexual maturation in all patients.

    Peptide
    hCG (human chorionic gonadotropin)
    Outcome
    IncreaseSexual maturation
    Study

    n = 14

    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    All patients achieved normal sexual maturation and normal or nearly normal adult male levels of testosterone.
    2 context sentences
    Summary · context
    Seven prepubertal males with isolated HH with a mean (+/-SD) age of 15.44+/-1.97 years and seven prepubertal males with panhypopituitarism-associated HH with a mean (+/-SD) age of 18.1+/-3.24 years were studied.
    Summary · context
    Human chorionic gonadotropin (1,000-1,500 IU IM) and FSH (75-100 IU SC) were administered every alternate day of the week until the total induction of puberty and spermatogenesis was achieved.

    In this study, hCG (human chorionic gonadotropin) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking hCG (human chorionic gonadotropin).

  2. 02HumanNot a test of hCG (human chorionic gonadotropin) aloneNon-randomized trialEfficacy outcome

    In adolescent males with hypogonadotropic hypogonadism, combined hCG and FSH produced normal or nearly normal adult male testosterone levels.

    In plain wordsIn adolescent males with hypogonadotropic hypogonadism, combined hCG and FSH produced normal or nearly normal adult male testosterone levels.

    Peptide
    hCG (human chorionic gonadotropin)
    Outcome
    IncreaseTestosterone
    Study

    n = 14

    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    All patients achieved normal sexual maturation and normal or nearly normal adult male levels of testosterone.
    2 context sentences
    Summary · context
    Seven prepubertal males with isolated HH with a mean (+/-SD) age of 15.44+/-1.97 years and seven prepubertal males with panhypopituitarism-associated HH with a mean (+/-SD) age of 18.1+/-3.24 years were studied.
    Summary · context
    Human chorionic gonadotropin (1,000-1,500 IU IM) and FSH (75-100 IU SC) were administered every alternate day of the week until the total induction of puberty and spermatogenesis was achieved.

    In this study, hCG (human chorionic gonadotropin) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking hCG (human chorionic gonadotropin).

  3. 03HumanNot a test of hCG (human chorionic gonadotropin) aloneNon-randomized trialEfficacy outcome

    In adolescents with isolated hypogonadotropic hypogonadism, combined hCG and FSH significantly increased testicular size.

    In plain wordsIn adolescents with isolated hypogonadotropic hypogonadism, combined hCG and FSH increased testicular size.

    Peptide
    hCG (human chorionic gonadotropin)
    Outcome
    IncreaseTesticular size in isolated HH
    Study

    n = 7

    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    The increase in testicular size was significant in both groups.
    2 context sentences
    Summary · context
    Seven prepubertal males with isolated HH with a mean (+/-SD) age of 15.44+/-1.97 years and seven prepubertal males with panhypopituitarism-associated HH with a mean (+/-SD) age of 18.1+/-3.24 years were studied.
    Summary · context
    Human chorionic gonadotropin (1,000-1,500 IU IM) and FSH (75-100 IU SC) were administered every alternate day of the week until the total induction of puberty and spermatogenesis was achieved.

    In this study, hCG (human chorionic gonadotropin) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking hCG (human chorionic gonadotropin).

  4. 04HumanNot a test of hCG (human chorionic gonadotropin) aloneNon-randomized trialEfficacy outcome

    In adolescents with panhypopituitarism-associated hypogonadotropic hypogonadism, combined hCG and FSH significantly increased testicular size.

    In plain wordsIn adolescents with panhypopituitarism-associated hypogonadotropic hypogonadism, combined hCG and FSH increased testicular size.

    Peptide
    hCG (human chorionic gonadotropin)
    Outcome
    IncreaseTesticular size in panhypopituitarism-associated HH
    Study

    n = 7

    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    The increase in testicular size was significant in both groups.
    2 context sentences
    Summary · context
    Seven prepubertal males with isolated HH with a mean (+/-SD) age of 15.44+/-1.97 years and seven prepubertal males with panhypopituitarism-associated HH with a mean (+/-SD) age of 18.1+/-3.24 years were studied.
    Summary · context
    Human chorionic gonadotropin (1,000-1,500 IU IM) and FSH (75-100 IU SC) were administered every alternate day of the week until the total induction of puberty and spermatogenesis was achieved.

    In this study, hCG (human chorionic gonadotropin) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking hCG (human chorionic gonadotropin).

  5. 05HumanNot a test of hCG (human chorionic gonadotropin) aloneNon-randomized trialEfficacy outcome

    With combined hCG and FSH, four of five evaluated adolescents with isolated HH showed sperm production.

    In plain wordsWith combined hCG and FSH, four of five evaluated adolescents with isolated HH produced sperm.

    Peptide
    hCG (human chorionic gonadotropin)
    Outcome
    IncreaseSperm production in isolated HH
    Study

    n = 5

    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Measurements

    Patients with positive sperm production
    4 patients (of 5 assessed)
    isolated HH

    Source sentences

    Summary
    Positive sperm production was assessed in four of five patients with isolated HH and in three of three patients with panhypopituitarism-associated HH.
    2 context sentences
    Summary · context
    Seven prepubertal males with isolated HH with a mean (+/-SD) age of 15.44+/-1.97 years and seven prepubertal males with panhypopituitarism-associated HH with a mean (+/-SD) age of 18.1+/-3.24 years were studied.
    Summary · context
    Human chorionic gonadotropin (1,000-1,500 IU IM) and FSH (75-100 IU SC) were administered every alternate day of the week until the total induction of puberty and spermatogenesis was achieved.

    In this study, hCG (human chorionic gonadotropin) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking hCG (human chorionic gonadotropin).

  6. 06HumanNot a test of hCG (human chorionic gonadotropin) aloneNon-randomized trialEfficacy outcome

    With combined hCG and FSH, three of three evaluated adolescents with panhypopituitarism-associated HH showed sperm production.

    In plain wordsWith combined hCG and FSH, three of three evaluated adolescents with panhypopituitarism-associated HH produced sperm.

    Peptide
    hCG (human chorionic gonadotropin)
    Outcome
    IncreaseSperm production in panhypopituitarism-associated HH
    Study

    n = 3

    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Measurements

    Patients with positive sperm production
    3 patients (of 3 assessed)
    panhypopituitarism-associated HH

    Source sentences

    Summary
    Positive sperm production was assessed in four of five patients with isolated HH and in three of three patients with panhypopituitarism-associated HH.
    2 context sentences
    Summary · context
    Seven prepubertal males with isolated HH with a mean (+/-SD) age of 15.44+/-1.97 years and seven prepubertal males with panhypopituitarism-associated HH with a mean (+/-SD) age of 18.1+/-3.24 years were studied.
    Summary · context
    Human chorionic gonadotropin (1,000-1,500 IU IM) and FSH (75-100 IU SC) were administered every alternate day of the week until the total induction of puberty and spermatogenesis was achieved.

    In this study, hCG (human chorionic gonadotropin) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking hCG (human chorionic gonadotropin).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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