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Study · Animal study (in vivo) · mouse · 1999

2 results

Cerebrolysin ameliorates performance deficits, and neuronal damage in apolipoprotein E-deficient mice.

Masliah E, Armasolo F, Veinbergs I, Mallory M, Samuel W

Pharmacology, biochemistry, and behavior1 Feb 1999Cited by 44 (Europe PMC)

PMID9972690 (opens in a new tab)DOI10.1016/s0091-3057(98)00144-0 (opens in a new tab)PepBankPUB-09972690
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In aged apoE-deficient mice, Cerebrolysin significantly improved Morris water maze performance compared with saline.

    In plain wordsIn mice deficient in apoE, Cerebrolysin improved water maze performance compared with saline.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseMorris water maze performance
    Study

    mousen: not reported in source

    Aged apolipoprotein E-deficient mice
    Comparator
    Saline-treated apoE-deficient mice
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    ApoE-deficient mice treated with Cerebrolysin showed a significant improved performance in the Morris water maze, compared to saline-treated apoE-deficient mice.
    1 context sentence
    Summary · context
    The main objective of this study was to determine if Cerebrolysin administration ameliorates the neurodegenerative and performance deficits in aged apolipoprotein E (apoE)-deficient mice.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In aged apoE-deficient mice, Cerebrolysin-associated performance improvement accompanied neuronal structure restoration, whereas saline-treated mice had disrupted synaptodendritic structure.

    In plain wordsIn mice deficient in apoE, Cerebrolysin-associated improvement accompanied restored nerve cell structure, compared with disrupted structure in saline-treated mice.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseNeuronal structure restoration
    Study

    mousen: not reported in source

    Aged apolipoprotein E-deficient mice
    Comparator
    Saline-treated apoE-deficient mice
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Although the improved performance in the Cerebrolysin-treated apoE-deficient mice was associated with restoration of the neuronal structure, the poor learning ability of saline-treated apoE-deficient mice was related to the a disrupted synaptodendritic structure.
    1 context sentence
    Summary · context
    The main objective of this study was to determine if Cerebrolysin administration ameliorates the neurodegenerative and performance deficits in aged apolipoprotein E (apoE)-deficient mice.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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