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Study · Animal study (in vivo) · rat · 1999

4 results

Interactions between the melanocortin system and leptin in control of sympathetic nerve traffic.

Haynes WG, Morgan DA, Djalali A, Sivitz WI, Mark AL

Hypertension (Dallas, Tex. : 1979)1 Jan 1999Cited by 258 (Europe PMC)

PMID9931162 (opens in a new tab)DOI10.1161/01.hyp.33.1.542 (opens in a new tab)PepBankPUB-09931162
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In anesthetized rats, intracerebroventricular MT-II produced a dose-dependent increase in brown adipose tissue sympathetic nerve activity.

    In plain wordsIn rats, melanotan II raised nerve activity to brown fat in a dose-dependent way.

    Peptide
    Melanotan II
    Outcome
    IncreaseBrown adipose tissue sympathetic nerve activity
    Study

    ratn: not reported in source

    anesthetized Sprague-Dawley rats
    Outcome group
    Brain and neuronal activity · Cardiovascular
    Studied dose
    200 to 600 pmol · intracerebroventricularAs given in this study (rat).

    Source sentences

    Summary
    Intracerebroventricular administration of the MC4-R agonist MT-II (200 to 600 pmol) produced a dose-dependent sympathoexcitation affecting BAT and renal and lumbar beds.
    1 context sentence
    Summary · context
    We tested the interactions between these systems in regulation of brown adipose tissue (BAT) and renal and lumbar SNA in anesthetized Sprague-Dawley rats.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In anesthetized rats, intracerebroventricular MT-II produced a dose-dependent increase in renal sympathetic nerve activity.

    In plain wordsIn rats, melanotan II raised nerve activity to the kidney in a dose-dependent way.

    Peptide
    Melanotan II
    Outcome
    IncreaseRenal sympathetic nerve activity
    Study

    ratn: not reported in source

    anesthetized Sprague-Dawley rats
    Outcome group
    Brain and neuronal activity · Cardiovascular
    Studied dose
    200 to 600 pmol · intracerebroventricularAs given in this study (rat).

    Source sentences

    Summary
    Intracerebroventricular administration of the MC4-R agonist MT-II (200 to 600 pmol) produced a dose-dependent sympathoexcitation affecting BAT and renal and lumbar beds.
    1 context sentence
    Summary · context
    We tested the interactions between these systems in regulation of brown adipose tissue (BAT) and renal and lumbar SNA in anesthetized Sprague-Dawley rats.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In anesthetized rats, intracerebroventricular MT-II produced a dose-dependent increase in lumbar sympathetic nerve activity.

    In plain wordsIn rats, melanotan II raised lumbar nerve activity in a dose-dependent way.

    Peptide
    Melanotan II
    Outcome
    IncreaseLumbar sympathetic nerve activity
    Study

    ratn: not reported in source

    anesthetized Sprague-Dawley rats
    Outcome group
    Brain and neuronal activity · Cardiovascular
    Studied dose
    200 to 600 pmol · intracerebroventricularAs given in this study (rat).

    Source sentences

    Summary
    Intracerebroventricular administration of the MC4-R agonist MT-II (200 to 600 pmol) produced a dose-dependent sympathoexcitation affecting BAT and renal and lumbar beds.
    1 context sentence
    Summary · context
    We tested the interactions between these systems in regulation of brown adipose tissue (BAT) and renal and lumbar SNA in anesthetized Sprague-Dawley rats.

Studies that did not test the peptide alone1

In this study, Melanotan II was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Melanotan II.

  1. 04AnimalNot a test of Melanotan II aloneAnimal study (in vivo)Mechanism

    In anesthetized rats, the antagonist SHU9119 completely blocked the sympathoexcitation caused by MT-II.

    In plain wordsIn rats, the blocker SHU9119 completely stopped the nerve activity rise caused by melanotan II.

    Peptide
    Melanotan II
    Outcome
    DecreaseBlock of the MT-II sympathoexcitation by SHU9119
    Study

    ratn: not reported in source

    anesthetized Sprague-Dawley rats
    Outcome group
    Brain and neuronal activity · Cardiovascular

    Source sentences

    Summary
    This response was completely blocked by the MC4-R antagonist SHU9119 (30 pmol ICV).
    1 context sentence
    Summary · context
    We tested the interactions between these systems in regulation of brown adipose tissue (BAT) and renal and lumbar SNA in anesthetized Sprague-Dawley rats.

    In this study, Melanotan II was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Melanotan II.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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