Skip to content

Study · Animal study (in vivo) · mouse · 1999

1 result

Response of melanocortin-4 receptor-deficient mice to anorectic and orexigenic peptides.

Marsh DJ, Hollopeter G, Huszar D, Laufer R, Yagaloff KA, Fisher SL, Burn P, Palmiter RD

Nature genetics1 Jan 1999Cited by 404 (Europe PMC)

PMID9916804 (opens in a new tab)DOI10.1038/5070 (opens in a new tab)PepBankPUB-09916804
Publisher pagePubMedAsk about this study
Jump to 1 result

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study1

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In Mc4r-deficient mice, MTII did not reduce food intake.

    In plain wordsIn mice lacking the Mc4r receptor, melanotan II did not reduce food intake.

    Peptide
    Melanotan II
    Outcome
    No significant changeAnorectic response to MTII in Mc4r-deficient mice
    Study

    mousen: not reported in source

    Mc4r-deficient (Mc4r-/-) mice
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Mc4r-deficient (Mc4r-/-) mice do not respond to the anorectic actions of MTII
    1 context sentence
    Summary · context
    These data suggest that alpha-MSH signalling transduced by Mc4r tonically inhibits feeding; however, it is not known to what extent this pathway mediates leptin signalling.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

PepBank is a research reference. Talk to a doctor before you use any peptide.