Growth hormone-releasing activity of thymulin on pituitary somatotropes is age dependent.

Brown OA, Sosa YE, Dardenne M, Pléau J, Goya RG

Neuroendocrinology1 Jan 1999Cited by 18 (Europe PMC)

PMID9892847DOI10.1159/000054399PepBankPUB-09892847

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study13

2 results from studies that gave the peptide. No result from this study comes from people.

01LabEx vivo tissueEfficacy outcome
In young and senescent rat pituitary cells, thymulin produced a logarithmic GH dose-response pattern.
In plain wordsIn lab tests, thymulin stimulated GH release from young and old rat pituitary cells.
Peptide
Thymulin (serum thymic factor)
Outcome
IncreaseGH release during perifusion
Study
ratn: not reported in source
Dispersed anterior pituitary cells from female Sprague-Dawley rats
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
10(-8) to 10(-5) MAs given in this study (rat).
Source sentences
Summary
Perifusion of young and senescent AP cells with thymulin doses, ranging from 10(-8) to 10(-5) M, gave a logarithmic dose-response pattern of GH.
2 context sentences(design, population, supporting numbers)
Summary · context
We assessed the ability of thymulin to influence the release of GH from dispersed anterior pituitary (AP) cells from young, middle-aged and senescent Sprague-Dawley female rats.
Summary · context
Perifused and incubated AP cells were used in different sets of experiments and GH release was measured by RIA.
Report a problemFND-0989284701
02LabEx vivo tissueEfficacy outcome
In rat pituitary cells, thymulin produced time-dependent and bell-shaped dose-dependent GH release, maximal at 10(-7) M.
In plain wordsIn lab tests, thymulin stimulated rat pituitary GH release with a bell-shaped dose response.
Peptide
Thymulin (serum thymic factor)
Outcome
IncreaseGH release during incubation
Study
ratn: not reported in source
Dispersed anterior pituitary cells from female Sprague-Dawley rats
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
10(-8)-10(-3) MAs given in this study (rat).
Source sentences
Summary
AP cells incubated with 10(-8)-10(-3) M thymulin showed a time- and dose-dependent response, the latter being bell-shaped with a maximum at 10(-7) M thymulin.
2 context sentences(design, population, supporting numbers)
Summary · context
We assessed the ability of thymulin to influence the release of GH from dispersed anterior pituitary (AP) cells from young, middle-aged and senescent Sprague-Dawley female rats.
Summary · context
Perifused and incubated AP cells were used in different sets of experiments and GH release was measured by RIA.
Report a problemFND-0989284704

Studies that did not test the peptide alone11

In this study, the peptide was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking the peptide.

03LabNot a test of Thymulin (serum thymic factor) aloneEx vivo tissueActivity measurement
In rat pituitary cell experiments, thymic epithelial cell supernatants showed GH secretagogue activity.
In plain wordsIn lab tests, thymic epithelial cell supernatants stimulated GH release.
Peptide
Thymulin (serum thymic factor)
Outcome
IncreaseGH secretagogue activity of TEC supernatants
Study
ratn: not reported in source
Dispersed anterior pituitary cells from female Sprague-Dawley rats
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Source sentences
Summary
Supernatants from TEC lines also showed GH secretagogue activity.
2 context sentences(design, population, supporting numbers)
Summary · context
We assessed the ability of thymulin to influence the release of GH from dispersed anterior pituitary (AP) cells from young, middle-aged and senescent Sprague-Dawley female rats.
Summary · context
Perifused and incubated AP cells were used in different sets of experiments and GH release was measured by RIA.
In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymulin (serum thymic factor).
Report a problemFND-0989284702
04LabNot a test of Thymulin (serum thymic factor) aloneEx vivo tissueEfficacy outcome
In rat pituitary cells exposed to thymulin, GH release was lower in senescent cells.
In plain wordsIn lab tests, old rat pituitary cells released less GH with thymulin than younger cells.
Peptide
Thymulin (serum thymic factor)
Outcome
DecreaseAge-related GH responsiveness
Study
ratn: not reported in source
Dispersed anterior pituitary cells from female Sprague-Dawley rats
Comparator
Younger cells
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Source sentences
Summary
The GH release was always lower in the senescent cells.
2 context sentences(design, population, supporting numbers)
Summary · context
We assessed the ability of thymulin to influence the release of GH from dispersed anterior pituitary (AP) cells from young, middle-aged and senescent Sprague-Dawley female rats.
Summary · context
Perifused and incubated AP cells were used in different sets of experiments and GH release was measured by RIA.
In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymulin (serum thymic factor).
Report a problemFND-0989284703
05LabNot a test of Thymulin (serum thymic factor) aloneEx vivo tissueMechanism
In rat pituitary cells, antithymulin serum completely blocked thymulin secretagogue activity.
In plain wordsIn lab tests, antithymulin serum blocked thymulin-induced GH release.
Peptide
Thymulin (serum thymic factor)
Outcome
DecreaseAntiserum blockade of GH release
Study
ratn: not reported in source
Dispersed anterior pituitary cells from female Sprague-Dawley rats
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Source sentences
Summary
Preincubation of thymulin with an antithymulin serum completely quenched the secretagogue activity of the hormone.
2 context sentences(design, population, supporting numbers)
Summary · context
We assessed the ability of thymulin to influence the release of GH from dispersed anterior pituitary (AP) cells from young, middle-aged and senescent Sprague-Dawley female rats.
Summary · context
Perifused and incubated AP cells were used in different sets of experiments and GH release was measured by RIA.
In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymulin (serum thymic factor).
Report a problemFND-0989284705
06LabNot a test of Thymulin (serum thymic factor) aloneEx vivo tissueMechanism
In young and middle-aged rat pituitary cells, thymulin with GHRH produced semiadditive GH release, with an additive effect in senescent cells.
In plain wordsIn lab tests, thymulin with GHRH produced semiadditive GH release in young and middle-aged rat cells and additive release in senescent cells.
Peptide
Thymulin (serum thymic factor)
Outcome
IncreaseGH release with GHRH
Study
ratn: not reported in source
Dispersed anterior pituitary cells from female Sprague-Dawley rats
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Source sentences
Summary
Coincubation of thymulin with GHRH revealed a semiadditive release of GH in young and middle-aged AP cells and an additive effect in senescent cells.
2 context sentences(design, population, supporting numbers)
Summary · context
We assessed the ability of thymulin to influence the release of GH from dispersed anterior pituitary (AP) cells from young, middle-aged and senescent Sprague-Dawley female rats.
Summary · context
Perifused and incubated AP cells were used in different sets of experiments and GH release was measured by RIA.
In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymulin (serum thymic factor).
Report a problemFND-0989284706
07LabNot a test of Thymulin (serum thymic factor) aloneEx vivo tissueMechanism
In middle-aged rat pituitary cells, thymulin with GHRP-6 synergistically stimulated GH release.
In plain wordsIn lab tests, thymulin with GHRP-6 synergistically stimulated GH release from middle-aged rat cells.
Peptide
Thymulin (serum thymic factor)
Outcome
IncreaseGH release with GHRP-6
Study
ratn: not reported in source
Dispersed anterior pituitary cells from female Sprague-Dawley rats
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Source sentences
Summary
In middle-aged AP cells, the synthetic GH secretagogue GHRP-6 showed a synergistic effect with thymulin on GH release.
2 context sentences(design, population, supporting numbers)
Summary · context
We assessed the ability of thymulin to influence the release of GH from dispersed anterior pituitary (AP) cells from young, middle-aged and senescent Sprague-Dawley female rats.
Summary · context
Perifused and incubated AP cells were used in different sets of experiments and GH release was measured by RIA.
In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymulin (serum thymic factor).
Report a problemFND-0989284707
08LabNot a test of GHRP-6 aloneEx vivo tissueMechanism
In middle-aged rat pituitary cells, GHRP‑6 with thymulin synergistically stimulated GH release.
In plain wordsIn lab tests, GHRP‑6 with thymulin synergistically stimulated GH release from middle-aged rat cells.
Peptide
GHRP-6
Outcome
IncreaseGH release with thymulin
Study
ratn: not reported in source
Dispersed anterior pituitary cells from female Sprague-Dawley rats
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Source sentences
Summary
In middle-aged AP cells, the synthetic GH secretagogue GHRP-6 showed a synergistic effect with thymulin on GH release.
2 context sentences(design, population, supporting numbers)
Summary · context
We assessed the ability of thymulin to influence the release of GH from dispersed anterior pituitary (AP) cells from young, middle-aged and senescent Sprague-Dawley female rats.
Summary · context
Perifused and incubated AP cells were used in different sets of experiments and GH release was measured by RIA.
In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.
Report a problemFND-0989284708
09LabNot a test of Thymulin (serum thymic factor) aloneEx vivo tissueMechanism
In rat pituitary cells, EGTA blocked thymulin-induced GH release.
In plain wordsIn lab tests, EGTA blocked thymulin-induced GH release from rat pituitary cells.
Peptide
Thymulin (serum thymic factor)
Outcome
DecreaseEGTA blockade of GH release
Study
ratn: not reported in source
Dispersed anterior pituitary cells from female Sprague-Dawley rats
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Source sentences
Summary
The calcium chelator EGTA, but not the calcium ionophore A23187, blocked the GH-releasing activity of thymulin in AP cells.
2 context sentences(design, population, supporting numbers)
Summary · context
We assessed the ability of thymulin to influence the release of GH from dispersed anterior pituitary (AP) cells from young, middle-aged and senescent Sprague-Dawley female rats.
Summary · context
Perifused and incubated AP cells were used in different sets of experiments and GH release was measured by RIA.
In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymulin (serum thymic factor).
Report a problemFND-0989284709
10LabNot a test of Thymulin (serum thymic factor) aloneEx vivo tissueMechanism
In rat pituitary cells, A23187 did not block thymulin-induced GH release.
In plain wordsIn lab tests, A23187 did not block thymulin-induced GH release from rat pituitary cells.
Peptide
Thymulin (serum thymic factor)
Outcome
No significant changeA23187 effect on GH release
Study
ratn: not reported in source
Dispersed anterior pituitary cells from female Sprague-Dawley rats
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Source sentences
Summary
The calcium chelator EGTA, but not the calcium ionophore A23187, blocked the GH-releasing activity of thymulin in AP cells.
2 context sentences(design, population, supporting numbers)
Summary · context
We assessed the ability of thymulin to influence the release of GH from dispersed anterior pituitary (AP) cells from young, middle-aged and senescent Sprague-Dawley female rats.
Summary · context
Perifused and incubated AP cells were used in different sets of experiments and GH release was measured by RIA.
In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymulin (serum thymic factor).
Report a problemFND-0989284710
11LabNot a test of Thymulin (serum thymic factor) aloneEx vivo tissueMechanism
In rat pituitary cells, caffeine, NaF and forskolin significantly increased thymulin-stimulated GH release.
In plain wordsIn lab tests, caffeine, NaF and forskolin increased thymulin-stimulated GH release from rat pituitary cells.
Peptide
Thymulin (serum thymic factor)
Outcome
IncreasecAMP enhancer effects on GH release
Study
ratn: not reported in source
Dispersed anterior pituitary cells from female Sprague-Dawley rats
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Source sentences
Summary
The cAMP enhancers, caffeine, NaF and forskolin significantly increased the thymulin-stimulated release of GH while trifluoperazine, a protein kinase C inhibitor, had no effect.
2 context sentences(design, population, supporting numbers)
Summary · context
We assessed the ability of thymulin to influence the release of GH from dispersed anterior pituitary (AP) cells from young, middle-aged and senescent Sprague-Dawley female rats.
Summary · context
Perifused and incubated AP cells were used in different sets of experiments and GH release was measured by RIA.
In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymulin (serum thymic factor).
Report a problemFND-0989284711
12LabNot a test of Thymulin (serum thymic factor) aloneEx vivo tissueMechanism
In rat pituitary cells, trifluoperazine did not affect thymulin-stimulated GH release.
In plain wordsIn lab tests, trifluoperazine did not affect thymulin-stimulated GH release from rat pituitary cells.
Peptide
Thymulin (serum thymic factor)
Outcome
No significant changeTrifluoperazine effect on GH release
Study
ratn: not reported in source
Dispersed anterior pituitary cells from female Sprague-Dawley rats
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Source sentences
Summary
The cAMP enhancers, caffeine, NaF and forskolin significantly increased the thymulin-stimulated release of GH while trifluoperazine, a protein kinase C inhibitor, had no effect.
2 context sentences(design, population, supporting numbers)
Summary · context
We assessed the ability of thymulin to influence the release of GH from dispersed anterior pituitary (AP) cells from young, middle-aged and senescent Sprague-Dawley female rats.
Summary · context
Perifused and incubated AP cells were used in different sets of experiments and GH release was measured by RIA.
In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymulin (serum thymic factor).
Report a problemFND-0989284712
13LabNot a test of Thymulin (serum thymic factor) aloneEx vivo tissueMechanism
In rat pituitary cells, LiCl potentiated thymulin-induced GH release.
In plain wordsIn lab tests, LiCl increased thymulin-induced GH release from rat pituitary cells.
Peptide
Thymulin (serum thymic factor)
Outcome
IncreaseLiCl effect on GH release
Study
ratn: not reported in source
Dispersed anterior pituitary cells from female Sprague-Dawley rats
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Source sentences
Summary
The inositol phosphate enhancer LiCl potentiated the action of thymulin on GH release.
2 context sentences(design, population, supporting numbers)
Summary · context
We assessed the ability of thymulin to influence the release of GH from dispersed anterior pituitary (AP) cells from young, middle-aged and senescent Sprague-Dawley female rats.
Summary · context
Perifused and incubated AP cells were used in different sets of experiments and GH release was measured by RIA.
In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymulin (serum thymic factor).
Report a problemFND-0989284713

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 4Current
21 Oct 2026, 15:58 UTC
Study results updated
Versions 2 to 3
21 Oct 2026, 13:55 UTC
The same notice was added 2 times, first on 21 Oct 2026, 12:50 UTC. The status did not change between them.
Study data updated · source update from Europe PMC
Version 1
9 Oct 2026, 03:13 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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