Effects of vasoactive intestinal peptide on prolactin secretion in three species of passerine birds.

Vleck CM, Patrick DJ

General and comparative endocrinology1 Jan 1999Cited by 23 (Europe PMC)

PMID9882553DOI10.1006/gcen.1998.7191PepBankPUB-09882553

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In Mexican jays, intravenous VIP at 50-100 microg/kg caused a large but short rise in plasma prolactin.
In plain wordsIn Mexican jays, VIP by injection into a vein briefly raised blood prolactin a lot.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
IncreasePlasma prolactin after iv VIP
Study
Mexican jayn: not reported in source
Aphelocoma ultramarina
Outcome group
Pituitary hormones · Endocrine and hormones
Studied dose
50-100 microg/kg body mass · intravenousAs given in this study (Mexican jay).
Source sentences
Summary
This study showed that iv injections of VIP (50-100 microg/kg body mass) result in a dramatic, but transitory, rise in plasma prolactin in Mexican jays (Aphelocoma ultramarina).
Report a problemFND-0988255301
02AnimalAnimal study (in vivo)Efficacy outcome
In blue jays, VIP injection significantly increased plasma prolactin.
In plain wordsIn blue jays, VIP injection raised blood prolactin.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
IncreasePlasma prolactin after VIP injection
Study
Blue jayn: not reported in source
Cyanocitta cristata
Outcome group
Pituitary hormones · Endocrine and hormones
Studied dose
Dose not stated
Source sentences
Summary
Significant increases in prolactin were also observed following VIP injection in blue jays (Cyanocitta cristata)
Report a problemFND-0988255302
03AnimalAnimal study (in vivo)Efficacy outcome
In zebra finches, VIP injection significantly increased plasma prolactin.
In plain wordsIn zebra finches, VIP injection raised blood prolactin.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
IncreasePlasma prolactin after VIP injection
Study
Zebra finchn: not reported in source
Poephilla guttata
Outcome group
Pituitary hormones · Endocrine and hormones
Studied dose
Dose not stated
Source sentences
Summary
Significant increases in prolactin were also observed following VIP injection in blue jays (Cyanocitta cristata) and zebra finches (Poephilla guttata).
Report a problemFND-0988255303
04AnimalAnimal study (in vivo)Efficacy outcome
After VIP, maximum prolactin was slightly lower in Mexican jays and very similar in blue jays and zebra finches compared with breeding birds of the same species.
In plain wordsAfter VIP, peak prolactin was slightly lower in Mexican jays and similar in blue jays and zebra finches compared with breeding birds.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
MixedMaximum prolactin after VIP versus breeding birds
Study
Mexican jay, blue jay and zebra finchn: not reported in source
Comparator
Breeding birds of the same species
Outcome group
Pituitary hormones · Endocrine and hormones
Studied dose
Dose not stated
Source sentences
Summary
At the dosage we used, maximum levels of prolactin attained were slightly lower (Mexican jays) or very similar (blue jay and zebra finch) to the maximum prolactin levels observed in other, breeding birds of the same species.
Report a problemFND-0988255304
05AnimalAnimal study (in vivo)Efficacy outcome
In zebra finches with low initial prolactin, VIP injection caused a greater than 10-fold increase in prolactin within 10 min.
In plain wordsIn zebra finches with low prolactin, VIP injection raised blood prolactin more than 10-fold within 10 minutes.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
IncreaseProlactin after VIP in birds with low initial prolactin
Study
Zebra finchn: not reported in source
Poephilla guttata with low initial prolactin
Outcome group
Pituitary hormones · Endocrine and hormones
Studied dose
Dose not stated · 10 minAs given in this study (Zebra finch).
Measurements
Prolactin increase
> 10 fold
zebra finches with low initial prolactin
Source sentences
Summary
In zebra finches that initially had low prolactin, VIP injection resulted in a greater than 10-fold increase in prolactin within 10 min
Report a problemFND-0988255305
06AnimalAnimal study (in vivo)Efficacy outcome
In zebra finches that already had elevated prolactin, VIP injection caused no further increase in prolactin.
In plain wordsIn zebra finches that already had high prolactin, VIP injection did not raise it further.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
No significant changeProlactin after VIP in birds with elevated initial prolactin
Study
Zebra finchn: not reported in source
Poephilla guttata with elevated initial prolactin
Outcome group
Pituitary hormones · Endocrine and hormones
Studied dose
Dose not stated
Source sentences
Summary
but those individuals that already had elevated prolactin showed no further increase in response to VIP.
Report a problemFND-0988255306
07AnimalAnimal study (in vivo)Efficacy outcome
In Mexican jays, subcutaneous pellets releasing 10 microg VIP/day gave a significant 78% rise in plasma prolactin compared with placebo pellets or a pellet releasing 5 microg/day.
In plain wordsIn Mexican jays, VIP pellets under the skin raised blood prolactin by 78% compared with placebo pellets.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
IncreasePlasma prolactin with 10 microg/day VIP pellets
Study
Mexican jayn: not reported in source
Aphelocoma ultramarina
Comparator
Placebo pellets or a pellet releasing 5 microg/day
Outcome group
Pituitary hormones · Endocrine and hormones
Studied dose
10 microg/day · subcutaneous implantAs given in this study (Mexican jay).
Measurements
Plasma prolactin rise
78%
10 microg VIP/day
Source sentences
Summary
Slow-release pellets of VIP implanted subcutaneously in Mexican jays and releasing 10 or 15 microg VIP/day (two or three pellets) produced a significant increase in plasma prolactin (78 and 92% rise, respectively) compared to birds with placebo pellets or with with one pellet releasing only 5 microg/day.
Report a problemFND-0988255307
08AnimalAnimal study (in vivo)Efficacy outcome
In Mexican jays, subcutaneous pellets releasing 15 microg VIP/day gave a significant 92% rise in plasma prolactin compared with placebo pellets or a pellet releasing 5 microg/day.
In plain wordsIn Mexican jays, VIP pellets under the skin raised blood prolactin by 92% compared with placebo pellets.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
IncreasePlasma prolactin with 15 microg/day VIP pellets
Study
Mexican jayn: not reported in source
Aphelocoma ultramarina
Comparator
Placebo pellets or a pellet releasing 5 microg/day
Outcome group
Pituitary hormones · Endocrine and hormones
Studied dose
15 microg/day · subcutaneous implantAs given in this study (Mexican jay).
Measurements
Plasma prolactin rise
92%
15 microg VIP/day
Source sentences
Summary
Slow-release pellets of VIP implanted subcutaneously in Mexican jays and releasing 10 or 15 microg VIP/day (two or three pellets) produced a significant increase in plasma prolactin (78 and 92% rise, respectively) compared to birds with placebo pellets or with with one pellet releasing only 5 microg/day.
Report a problemFND-0988255308

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
12 Oct 2026, 12:58 UTC
Study results updated
Version 1
9 Oct 2026, 12:41 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

MeSH terms

PepBank is a research reference. Talk to a doctor before you use any peptide.