In rats after carbon monoxide poisoning and spreading depression, cerebrolysin improved hippocampal recovery, with increased spreading depression wave amplitude.
In plain wordsIn rats after carbon monoxide poisoning and induced depolarization, cerebrolysin increased hippocampal wave amplitude compared with untreated animals.
- Peptide
- Cerebrolysin
- Outcome
- IncreaseHippocampal spreading depression wave amplitude
- Study
ratn: not reported in source
Carbon monoxide poisoning with spreading depression- Comparator
- Untreated animals
- Outcome group
- Neuroprotection · Nervous system and cognition
- Studied dose
- 2.5 ml/kg per day · 14 daysAs given in this study (rat).
Source sentences
CL-treatment (2.5 ml/kg per day) started after CO administration and continued for 14 days significantly improved hippocampal recovery manifested by increased amplitude of SD waves.
2 context sentences(design, population, supporting numbers)
A model of acute carbon monoxide poisoning combined with spreading depression (SD) induced metabolic stress was used to examine the protective effects of cerebrolysin (CL) on the development of electrophysiological, behavioral and morphological signs of hypoxic damage.
Capillary electrodes were implanted into the neocortex and hippocampus of anesthetized rats which were then exposed for 90 min to breathing of 0.8% to 0.5% CO, while 3 to 4 waves of cortical and hippocampal SD were elicited by microinjections of 5% KCl.