Skip to content

Study · Not a test of the peptide alone · 1998

4 results

Effects of pH, electric current, and enzyme inhibitors on iontophoresis of delta sleep-inducing peptide.

Chiang CH, Shao CH, Chen JL

Drug development and industrial pharmacy1 May 1998Cited by 6 (Europe PMC)

PMID9876605 (opens in a new tab)DOI10.3109/03639049809085640 (opens in a new tab)PepBankPUB-09876605
Publisher pagePubMedAsk about this study
Jump to 4 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone4

In this study, Delta sleep-inducing peptide (DSIP) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Delta sleep-inducing peptide (DSIP).

  1. 01LabNot a test of Delta sleep-inducing peptide (DSIP) aloneEx vivo tissueOther

    DSIP was fairly stable in buffer solutions between pH 4 and 9.

    In plain wordsIn lab tests, DSIP was fairly stable in buffers across a wide pH range.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    Not applicableDSIP stability at pH 4-9
    Study

    n: not reported in source

    skin homogenate and iontophoretic skin delivery
    Outcome group
    Pharmacokinetics · Pharmacology

    Source sentences

    Summary
    DSIP was fairly stable in pH 4-9 buffer solutions
    1 context sentence
    Summary · context
    Delta sleep-inducing peptide (DSIP), a peptide of nine amino acid residues, was used as a model drug to investigate the effects of pH, electric current, and enzyme inhibitors on the transdermal iontophoretic delivery of peptide drugs.

    In this study, Delta sleep-inducing peptide (DSIP) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Delta sleep-inducing peptide (DSIP).

  2. 02LabNot a test of Delta sleep-inducing peptide (DSIP) aloneEx vivo tissueOther

    Skin enzymes cleaved DSIP during iontophoretic delivery.

    In plain wordsIn lab tests, enzymes in skin broke down DSIP during delivery with an electric current.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    Not applicableDSIP degradation by skin enzymes during iontophoresis
    Study

    n: not reported in source

    skin homogenate and iontophoretic skin delivery
    Outcome group
    Pharmacokinetics · Pharmacology

    Source sentences

    Summary
    but was cleaved by the skin enzymes during iontophoretic delivery.
    1 context sentence
    Summary · context
    Delta sleep-inducing peptide (DSIP), a peptide of nine amino acid residues, was used as a model drug to investigate the effects of pH, electric current, and enzyme inhibitors on the transdermal iontophoretic delivery of peptide drugs.

    In this study, Delta sleep-inducing peptide (DSIP) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Delta sleep-inducing peptide (DSIP).

  3. 03LabNot a test of Delta sleep-inducing peptide (DSIP) aloneEx vivo tissueOther

    Enzyme inhibitors (o-phenanthroline, EDTA, dilucine and sodium deoxycholate) inhibited DSIP degradation to a certain extent in skin homogenate.

    In plain wordsIn lab tests, several enzyme blockers slowed the breakdown of DSIP in skin material.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    DecreaseDSIP degradation in skin homogenate with enzyme inhibitors
    Study

    n: not reported in source

    skin homogenate and iontophoretic skin delivery
    Outcome group
    Pharmacokinetics · Pharmacology

    Source sentences

    Summary
    Enzyme inhibitors, such as o-phenanthroline, ethylene-diaminetetraacetic acid (EDTA), dilucine, and sodium deoxycholate, could inhibit the degradation of DSIP to a certain extent in the skin homogenate.
    1 context sentence
    Summary · context
    Delta sleep-inducing peptide (DSIP), a peptide of nine amino acid residues, was used as a model drug to investigate the effects of pH, electric current, and enzyme inhibitors on the transdermal iontophoretic delivery of peptide drugs.

    In this study, Delta sleep-inducing peptide (DSIP) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Delta sleep-inducing peptide (DSIP).

  4. 04LabNot a test of Delta sleep-inducing peptide (DSIP) aloneEx vivo tissuePharmacokinetics

    Adding 0.2 mM o-phenanthroline at pH 4 significantly enhanced DSIP penetration during iontophoresis; flux was about eight times that of the control without o-phenanthroline at pH 7.4.

    In plain wordsIn lab tests, adding an enzyme blocker raised DSIP skin penetration about eight times compared with the control without it.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseDSIP flux with o-phenanthroline at pH 4
    Study

    n: not reported in source

    skin homogenate and iontophoretic skin delivery
    Comparator
    Iontophoresis without o-phenanthroline at pH 7.4
    Outcome group
    Pharmacokinetics · Pharmacology

    Source sentences

    Summary
    By using 0.2 mM o-phenanthroline in the iontophoretic delivery of DSIP at pH 4, we were able to significantly enhance the penetration of DSIP. The flux was about eight times as much as control (without o-phenanthroline) at pH 7.4.
    1 context sentence
    Summary · context
    Delta sleep-inducing peptide (DSIP), a peptide of nine amino acid residues, was used as a model drug to investigate the effects of pH, electric current, and enzyme inhibitors on the transdermal iontophoretic delivery of peptide drugs.

    In this study, Delta sleep-inducing peptide (DSIP) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Delta sleep-inducing peptide (DSIP).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 08:55 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.