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Study · In vitro (cells) · 1999

1 result

Protein kinases C-gamma and -delta are involved in insulin-like growth factor I-induced migration of colonic epithelial cells.

André F, Rigot V, Remacle-Bonnet M, Luis J, Pommier G, Marvaldi J

Gastroenterology1 Jan 1999Cited by 58 (Europe PMC)

PMID9869604 (opens in a new tab)DOI10.1016/s0016-5085(99)70230-1 (opens in a new tab)PepBankPUB-09869604
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study1

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Activity measurement

    Des(1‑3)-IGF-I induced HT29-D4 colonic epithelial cell migration more potently than IGF-I.

    In plain wordsIn cells, des(1‑3)-IGF-I stimulated colon cell movement more potently than IGF-I.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    IncreaseMigration potency
    Study

    humann: not reported in source

    HT29-D4 colonic epithelial cells
    Comparator
    IGF-I
    Outcome group
    Wound healing · Gastrointestinal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Des(1-3)-IGF-I, a truncated analogue of IGF-I, was more potent than IGF-I, suggesting that IGF-binding proteins secreted in the medium modulated IGF-I-induced cell migration.
    2 context sentences
    Summary · context
    This study investigated the insulin-like growth factor I (IGF-I) signaling pathway leading to HT29-D4 human colonic epithelial cell line migration.
    Summary · context
    IGF-stimulated cell migration was determined using a wound model in the presence or absence of kinase inhibitors.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 2

    21 Oct 2026, 13:52 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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