Involvement of insulin-like growth factor-1 and its binding proteins in proliferation and differentiation of murine bone marrow-derived macrophage precursors.

Long E, Huynh HT, Zhao X

Endocrine1 Oct 1998Cited by 16 (Europe PMC)

PMID9867252DOI10.1385/endo:9:2:185PepBankPUB-09867252

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

01LabIn vitro (cells)Efficacy outcome
In murine bone marrow-derived macrophage precursors, long R3 IGF-1 potentiated proliferation on day 0, as did rhIGF-1 and des (1-3) IGF-1.
In plain wordsIn mouse immune precursor cells in a dish, long R3 IGF-1 increased cell growth, as did regular IGF-1.
Peptide
IGF-1 LR3
Outcome
IncreaseProliferation of BMDM precursors on day 0
Study
mousen: not reported in source
murine bone marrow-derived macrophage precursors
Outcome group
Immune response · Immune and inflammation
Studied dose
Dose not stated
Source sentences
Summary
These three forms of IGF-1 all potentiated the proliferation of freshly isolated BMDM precursors (d 0)
2 context sentences(design, population, supporting numbers)
Summary · context
Two IGF-1 analogs (long R3 IGF-1 and des [1-3] IGF-1) were also used in parallel with regular IGF-1 to indicate the involvement of IGFBPs in BMDM development.
Summary · context
In the present study, the involvement of IGF-1 and IGFBPs in proliferation and differentiation of murine bone marrow-derived macrophages (BMDM) was investigated.
Report a problemFND-0986725201
02LabIn vitro (cells)Efficacy outcome
In murine bone marrow-derived macrophage precursors, long R3 IGF-1, like rhIGF-1 but unlike des (1-3) IGF-1, continued to stimulate proliferation on day 1.
In plain wordsIn mouse immune precursor cells in a dish, long R3 IGF-1 kept stimulating cell growth on day 1, unlike des (1-3) IGF-1.
Peptide
IGF-1 LR3
Outcome
IncreaseProliferation of BMDM precursors on day 1
Study
mousen: not reported in source
murine bone marrow-derived macrophage precursors
Outcome group
Immune response · Immune and inflammation
Studied dose
Dose not stated
Source sentences
Summary
rhIGF-1 and long R3 IGF-1, but not des (1-3) IGF-1, continued to stimulate the cell proliferation on d 1.
1 context sentence(design, population, supporting numbers)
Summary · context
In the present study, the involvement of IGF-1 and IGFBPs in proliferation and differentiation of murine bone marrow-derived macrophages (BMDM) was investigated.
Report a problemFND-0986725202
03LabIn vitro (cells)Efficacy outcome
In murine bone marrow-derived macrophage precursors, long R3 IGF-1 enhanced differentiation on day 4, as measured by mannose receptor expression, whereas rhIGF-1 did not.
In plain wordsIn mouse immune precursor cells in a dish, long R3 IGF-1 increased maturation on day 4, but regular IGF-1 did not.
Peptide
IGF-1 LR3
Outcome
IncreaseBMDM differentiation on day 4 (mannose receptor expression)
Study
mousen: not reported in source
murine bone marrow-derived macrophage precursors
Outcome group
Immune response · Immune and inflammation
Studied dose
Dose not stated
Source sentences
Summary
Long R3 IGF-1 and des (1-3) IGF-1, but not rhIGF-1, enhanced BMDM differentiation on d 4.
2 context sentences(design, population, supporting numbers)
Summary · context
The effects of these three forms of IGF-1 on BMDM differentiation were investigated using mannose receptor expression as a marker.
Summary · context
In the present study, the involvement of IGF-1 and IGFBPs in proliferation and differentiation of murine bone marrow-derived macrophages (BMDM) was investigated.
Report a problemFND-0986725203
04LabIn vitro (cells)Activity measurement
In freshly isolated murine macrophage precursors, des(1‑3)IGF-1 enhanced proliferation.
In plain wordsIn cells from mice, des(1‑3)IGF-1 increased proliferation of freshly isolated macrophage precursors.
Peptide
IGF-1 DES (des(1-3)IGF-I)
Outcome
IncreaseFresh precursor proliferation
Study
mousen: not reported in source
Bone marrow-derived macrophage precursors
Outcome group
Immune response · Immune and inflammation
Studied dose
Dose not stated · 24 hAs given in this study (mouse).
Source sentences
Summary
These three forms of IGF-1 all potentiated the proliferation of freshly isolated BMDM precursors (d 0).
2 context sentences(design, population, supporting numbers)
Summary · context
Two IGF-1 analogs (long R3 IGF-1 and des [1-3] IGF-1) were also used in parallel with regular IGF-1 to indicate the involvement of IGFBPs in BMDM development.
Summary · context
Cells were cultured in complete media containing 20% LCM for different time periods, and then incubated in serum-free media in the presence of rhIGF-1 or its analogs for 24 h.
Report a problemFND-0986725204
05LabIn vitro (cells)Activity measurement
In murine macrophage precursors, des(1‑3)IGF-1 did not continue to stimulate proliferation on day 1.
In plain wordsIn cells from mice, des(1‑3)IGF-1 did not continue to increase macrophage precursor proliferation on day 1.
Peptide
IGF-1 DES (des(1-3)IGF-I)
Outcome
No significant changeDay 1 precursor proliferation
Study
mousen: not reported in source
Bone marrow-derived macrophage precursors
Outcome group
Immune response · Immune and inflammation
Studied dose
Dose not stated · 24 hAs given in this study (mouse).
Source sentences
Summary
rhIGF-1 and long R3 IGF-1, but not des (1-3) IGF-1, continued to stimulate the cell proliferation on d 1.
2 context sentences(design, population, supporting numbers)
Summary · context
Two IGF-1 analogs (long R3 IGF-1 and des [1-3] IGF-1) were also used in parallel with regular IGF-1 to indicate the involvement of IGFBPs in BMDM development.
Summary · context
Cells were cultured in complete media containing 20% LCM for different time periods, and then incubated in serum-free media in the presence of rhIGF-1 or its analogs for 24 h.
Report a problemFND-0986725205
06LabIn vitro (cells)Activity measurement
In murine bone marrow-derived macrophages, des(1‑3)IGF-1 enhanced differentiation on day 4, assessed through mannose receptor expression.
In plain wordsIn cells from mice, des(1‑3)IGF-1 increased macrophage differentiation on day 4.
Peptide
IGF-1 DES (des(1-3)IGF-I)
Outcome
IncreaseDay 4 macrophage differentiation
Study
mousen: not reported in source
Bone marrow-derived macrophage precursors
Outcome group
Immune response · Immune and inflammation
Studied dose
Dose not stated · 24 hAs given in this study (mouse).
Source sentences
Summary
Long R3 IGF-1 and des (1-3) IGF-1, but not rhIGF-1, enhanced BMDM differentiation on d 4.
3 context sentences(design, population, supporting numbers)
Summary · context
The effects of these three forms of IGF-1 on BMDM differentiation were investigated using mannose receptor expression as a marker.
Summary · context
Two IGF-1 analogs (long R3 IGF-1 and des [1-3] IGF-1) were also used in parallel with regular IGF-1 to indicate the involvement of IGFBPs in BMDM development.
Summary · context
Cells were cultured in complete media containing 20% LCM for different time periods, and then incubated in serum-free media in the presence of rhIGF-1 or its analogs for 24 h.
Report a problemFND-0986725206

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Versions 3 to 4Current
21 Oct 2026, 13:52 UTC
The same notice was added 2 times, first on 21 Oct 2026, 12:50 UTC. The status did not change between them.
Study data updated · source update from Europe PMC
Version 2
13 Oct 2026, 21:44 UTC
Study results updated
Version 1
13 Oct 2026, 16:31 UTC
First added · source update from Europe PMC

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Involvement of insulin-like growth factor-1 and its binding proteins in proliferation and differentiation of murine bone marrow-derived macrophage precursors.

Summary

Results from this study6

Version history

Subjects

Publication types

MeSH terms