Effect of growth hormone-releasing peptide 1-6 on GH secretion-stimulated by GHRH and pyridostigmine in lambs.

Rico M, Rueda V, Lorenzo MT, Núñez A, De la Cruz LF

Journal of physiology and biochemistry1 Jun 1998Cited by 2 (Europe PMC)

PMID9858126DOI10.1007/bf03655566PepBankPUB-09858126

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

5 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Activity measurement
In lambs, adding GHRP‑6 to low-dose GHRH increased the GH peak compared with GHRH alone.
In plain wordsIn lambs, adding GHRP‑6 to GHRH increased the growth hormone peak compared with GHRH alone.
Peptide
GHRP-6
Outcome
IncreaseGH peak added to GHRH
Study
sheepn = 6
Lambs
Comparator
GHRH alone
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
10 microg/kgAs given in this study (sheep).
Source sentences
Summary
The results have shown that the combination of GHRH plus GHRP-6, at low doses, causes higher GH peak (p < 0.05) and higher GH area under curve (p < 0.05) with respect to administration of GHRH alone.
1 context sentence(design, population, supporting numbers)
Summary · context
In in vivo studies, six lambs received 15 microg/kg GHRH (1-29) or 15 microg/kg GHRH plus 10 microg/kg GHRP-6 and six other lambs received 100 microg/kg GHRP-6 or 3 mg/kg pyridostigmine plus 100 microg/kg GHRP-6.
Report a problemFND-0985812604
02AnimalAnimal study (in vivo)Activity measurement
In lambs, adding GHRP‑6 to low-dose GHRH increased GH area under the curve compared with GHRH alone.
In plain wordsIn lambs, adding GHRP‑6 to GHRH increased total growth hormone response compared with GHRH alone.
Peptide
GHRP-6
Outcome
IncreaseGH area under curve added to GHRH
Study
sheepn = 6
Lambs
Comparator
GHRH alone
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
10 microg/kgAs given in this study (sheep).
Source sentences
Summary
The results have shown that the combination of GHRH plus GHRP-6, at low doses, causes higher GH peak (p < 0.05) and higher GH area under curve (p < 0.05) with respect to administration of GHRH alone.
1 context sentence(design, population, supporting numbers)
Summary · context
In in vivo studies, six lambs received 15 microg/kg GHRH (1-29) or 15 microg/kg GHRH plus 10 microg/kg GHRP-6 and six other lambs received 100 microg/kg GHRP-6 or 3 mg/kg pyridostigmine plus 100 microg/kg GHRP-6.
Report a problemFND-0985812605
03LabIn vitro (cells)Activity measurement
In lamb pituitary cells, GHRP‑6 stimulated GH release.
In plain wordsIn lamb pituitary cells, GHRP‑6 increased growth hormone release.
Peptide
GHRP-6
Outcome
IncreaseGH release
Study
sheepn: not reported in source
Lamb adenohypophysial cell cultures
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
1 microMAs given in this study (sheep).
Source sentences
Summary
Both peptides released GH, GHRP-6 being less potent than GHRH, and the GH response to GHRH and GHRP-6 not being synergistic, without statistically significant differences between GHRH+GHRP-6 and GHRH alone.
1 context sentence(design, population, supporting numbers)
Summary · context
Lamb adenohypophysial cell cultures were subjected to a challenge with 1) 10 nM GHRH-1-29; 2) 1 microM GHRP-6; and 3) 10 nM GHRH plus 1 microM GHRP-6.
Report a problemFND-0985812601
04LabIn vitro (cells)Activity measurement
In lamb pituitary cells, GHRP‑6 was less potent than GHRH at releasing GH.
In plain wordsIn lamb pituitary cells, GHRP‑6 released growth hormone less potently than GHRH.
Peptide
GHRP-6
Outcome
DecreaseGH potency relative to GHRH
Study
sheepn: not reported in source
Lamb adenohypophysial cell cultures
Comparator
GHRH
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
1 microMAs given in this study (sheep).
Source sentences
Summary
Both peptides released GH, GHRP-6 being less potent than GHRH, and the GH response to GHRH and GHRP-6 not being synergistic, without statistically significant differences between GHRH+GHRP-6 and GHRH alone.
Report a problemFND-0985812602
05LabIn vitro (cells)Activity measurement
In lamb pituitary cells, adding GHRP‑6 to GHRH did not significantly increase GH release.
In plain wordsIn lamb pituitary cells, GHRP‑6 plus GHRH did not significantly increase growth hormone release compared with GHRH alone.
Peptide
GHRP-6
Outcome
No significant changeGH response added to GHRH
Study
sheepn: not reported in source
Lamb adenohypophysial cell cultures
Comparator
GHRH alone
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
1 microMAs given in this study (sheep).
Source sentences
Summary
Both peptides released GH, GHRP-6 being less potent than GHRH, and the GH response to GHRH and GHRP-6 not being synergistic, without statistically significant differences between GHRH+GHRP-6 and GHRH alone.
Report a problemFND-0985812603

Studies that did not test the peptide alone2

In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking GHRP-6.

06AnimalNot a test of GHRP-6 aloneAnimal study (in vivo)Activity measurement
In lambs, pyridostigmine plus GHRP‑6 increased the GH peak compared with GHRP‑6 alone.
In plain wordsIn lambs, pyridostigmine plus GHRP‑6 increased the growth hormone peak compared with GHRP‑6 alone.
Peptide
GHRP-6
Outcome
IncreaseGH peak with pyridostigmine
Study
sheepn = 6
Lambs
Comparator
GHRP-6 alone
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Source sentences
Summary
The administration of GHRP-6 plus pyridostigmine produced in a stronger GH response to GHRP-6 (100 microg/kg) in the amplitude of the GH peak (p < 0.001) and in the area under the GH response curve (p < 0.001).
In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.
Report a problemFND-0985812606
07AnimalNot a test of GHRP-6 aloneAnimal study (in vivo)Activity measurement
In lambs, pyridostigmine plus GHRP‑6 increased GH area under the curve compared with GHRP‑6 alone.
In plain wordsIn lambs, pyridostigmine plus GHRP‑6 increased total growth hormone response compared with GHRP‑6 alone.
Peptide
GHRP-6
Outcome
IncreaseGH area under curve with pyridostigmine
Study
sheepn = 6
Lambs
Comparator
GHRP-6 alone
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Source sentences
Summary
The administration of GHRP-6 plus pyridostigmine produced in a stronger GH response to GHRP-6 (100 microg/kg) in the amplitude of the GH peak (p < 0.001) and in the area under the GH response curve (p < 0.001).
In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.
Report a problemFND-0985812607

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
21 Oct 2026, 15:58 UTC
Study results updated
Version 1
9 Oct 2026, 03:13 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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