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Study · Animal study (in vivo) · rat · 1998

2 results

Effects of delta-sleep-inducing peptide on NMDA-induced convulsive activity in rats.

Shandra AA, Godlevskii LS, Brusentsov AI, Karlyuga VA

Neuroscience and behavioral physiology1 Nov 1998Cited by 9 (Europe PMC)

PMID9850965 (opens in a new tab)DOI10.1007/bf02462991 (opens in a new tab)PepBankPUB-09850965
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats, DSIP raised the NMDA dose needed to induce clonic convulsions by 2.3-fold.

    In plain wordsIn rats, DSIP made it take a higher NMDA dose to cause clonic convulsions.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseNMDA ED100 for clonic convulsions
    Study

    ratn: not reported in source

    NMDA-induced convulsions
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    100 micrograms/kg · intraperitonealAs given in this study (rat).

    Measurements

    fold increase in NMDA ED100 (clonic convulsions)
    2.3 fold
    DSIP 100 micrograms/kg

    Source sentences

    Summary
    Determination of these parameters after administration of delta-sleep-inducing peptide (100 micrograms/kg, i.p.) revealed 2.3- and 4.46-fold increases.
    1 context sentence
    Summary · context
    Acute experiments on rats showed that the ED100 of NMDA for induction of clonic convulsions was 0.53 microgram, while the ED100 of NMDA for inducing tonic extension of the forelimbs was 5.02 micrograms/animal.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats, DSIP raised the NMDA dose needed to induce tonic extension of the forelimbs by 4.46-fold.

    In plain wordsIn rats, DSIP made it take a higher NMDA dose to cause tonic forelimb extension.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseNMDA ED100 for tonic extension of the forelimbs
    Study

    ratn: not reported in source

    NMDA-induced convulsions
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    100 micrograms/kg · intraperitonealAs given in this study (rat).

    Measurements

    fold increase in NMDA ED100 (tonic extension)
    4.46 fold
    DSIP 100 micrograms/kg

    Source sentences

    Summary
    Determination of these parameters after administration of delta-sleep-inducing peptide (100 micrograms/kg, i.p.) revealed 2.3- and 4.46-fold increases.
    1 context sentence
    Summary · context
    Acute experiments on rats showed that the ED100 of NMDA for induction of clonic convulsions was 0.53 microgram, while the ED100 of NMDA for inducing tonic extension of the forelimbs was 5.02 micrograms/animal.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 08:55 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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