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Study · Animal study (in vivo) · rat · 1998

6 results

Involvement of capsaicin sensitive primary afferents in thymulin-induced hyperalgesia.

Saadé NE, Major SC, Jabbur SJ, Atweh SF, Kanaan SA, Safieh-Garabedian B

Journal of neuroimmunology1 Nov 1998Cited by 15 (Europe PMC)

PMID9846833 (opens in a new tab)DOI10.1016/s0165-5728(98)00176-3 (opens in a new tab)PepBankPUB-09846833
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Safety outcome

    In rats, intraplantar or intraperitoneal thymulin produced thermal hyperalgesia.

    In plain wordsIn rats, thymulin injections increased sensitivity to heat pain.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    IncreaseThermal hyperalgesia
    Study

    ratn: not reported in source

    rats
    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    5 ng intraplantar or 50 ng intraperitoneal · intraplantar or intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    Intraplantar (5 ng) or intraperitoneal (50 ng) injections of thymulin, produced both thermal and mechanical hyperalgesia in rats.
  2. 02AnimalAnimal study (in vivo)Safety outcome

    In rats, intraplantar or intraperitoneal thymulin produced mechanical hyperalgesia.

    In plain wordsIn rats, thymulin injections increased sensitivity to mechanical pain.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    IncreaseMechanical hyperalgesia
    Study

    ratn: not reported in source

    rats
    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    5 ng intraplantar or 50 ng intraperitoneal · intraplantar or intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    Intraplantar (5 ng) or intraperitoneal (50 ng) injections of thymulin, produced both thermal and mechanical hyperalgesia in rats.

Studies that did not test the peptide alone4

In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymulin (serum thymic factor).

  1. 03AnimalNot a test of Thymulin (serum thymic factor) aloneAnimal study (in vivo)Mechanism

    In rats, capsaicin treatment significantly reduced thymulin-induced hyperalgesia.

    In plain wordsIn rats, capsaicin treatment reduced pain sensitivity induced by thymulin.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    DecreaseHyperalgesia with capsaicin
    Study

    ratn: not reported in source

    rats
    Outcome group
    Pain · Nervous system and cognition

    Source sentences

    Summary
    Both capsaicin and SDV reduced significantly thymulin-induced hyperalgesia.
    1 context sentence
    Summary · context
    Different groups of rats were subjected to either treatment with capsaicin or to surgical subdiaphragmatic vagotomy (SDV).

    In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymulin (serum thymic factor).

  2. 04AnimalNot a test of Thymulin (serum thymic factor) aloneAnimal study (in vivo)Mechanism

    In rats, subdiaphragmatic vagotomy significantly reduced thymulin-induced hyperalgesia.

    In plain wordsIn rats, cutting the vagus nerve below the diaphragm reduced pain sensitivity induced by thymulin.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    DecreaseHyperalgesia with vagotomy
    Study

    ratn: not reported in source

    rats
    Outcome group
    Pain · Nervous system and cognition

    Source sentences

    Summary
    Both capsaicin and SDV reduced significantly thymulin-induced hyperalgesia.
    1 context sentence
    Summary · context
    Different groups of rats were subjected to either treatment with capsaicin or to surgical subdiaphragmatic vagotomy (SDV).

    In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymulin (serum thymic factor).

  3. 05AnimalNot a test of Thymulin (serum thymic factor) aloneAnimal study (in vivo)Mechanism

    In rats, capsaicin treatment and vagotomy differentially affected thymulin modulation of nerve growth factor levels.

    In plain wordsIn rats, capsaicin treatment and vagus nerve surgery had different effects on thymulin-related changes in nerve growth factor.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    Direction not reportedNGF modulation with afferent interventions
    Study

    ratn: not reported in source

    rats
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition

    Source sentences

    Summary
    On the other hand, these treatments elicited differential effects on the modulation by thymulin of the levels of nerve growth factor and interleukin 1beta.
    1 context sentence
    Summary · context
    Different groups of rats were subjected to either treatment with capsaicin or to surgical subdiaphragmatic vagotomy (SDV).

    In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymulin (serum thymic factor).

  4. 06AnimalNot a test of Thymulin (serum thymic factor) aloneAnimal study (in vivo)Mechanism

    In rats, capsaicin treatment and vagotomy differentially affected thymulin modulation of interleukin 1beta levels.

    In plain wordsIn rats, capsaicin treatment and vagus nerve surgery had different effects on thymulin-related changes in interleukin 1beta.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    Direction not reportedIL-1beta modulation with afferent interventions
    Study

    ratn: not reported in source

    rats
    Outcome group
    Inflammation markers · Immune and inflammation

    Source sentences

    Summary
    On the other hand, these treatments elicited differential effects on the modulation by thymulin of the levels of nerve growth factor and interleukin 1beta.
    1 context sentence
    Summary · context
    Different groups of rats were subjected to either treatment with capsaicin or to surgical subdiaphragmatic vagotomy (SDV).

    In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymulin (serum thymic factor).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 2

    21 Oct 2026, 13:55 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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