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Study · Animal study (in vivo) · rat · 1998

4 results

The growth hormone secretagogue KP-102-induced stimulation of food intake is modified by fasting, restraint stress, and somatostatin in rats.

Shibasaki T, Yamauchi N, Takeuchi K, Ishii S, Sugihara H, Wakabayashi I

Neuroscience letters1 Oct 1998Cited by 10 (Europe PMC)

PMID9839714 (opens in a new tab)DOI10.1016/s0304-3940(98)00695-8 (opens in a new tab)PepBankPUB-09839714
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In freely-fed rats, KP-102 stimulated food intake.

    In plain wordsIn freely-fed rats, KP-102 increased how much they ate.

    Peptide
    GHRP-2
    Outcome
    IncreaseFood intake in freely-fed rats
    Study

    ratn: not reported in source

    Rats
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    KP-102-induced stimulation of food intake was observed in freely-fed rats
    1 context sentence
    Summary · context
    The effects of fasting, restraint stress, and intracerebroventricular (i.c.v.) injection of somatostatin on the growth hormone secretagogue, KP-102-induced stimulation of food intake were examined in rats.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats starved for 24 h, KP-102 did not stimulate food intake.

    In plain wordsIn rats that had not eaten for 24 hours, KP-102 did not increase how much they ate.

    Peptide
    GHRP-2
    Outcome
    No significant changeFood intake in 24-h starved rats
    Study

    ratn: not reported in source

    Rats
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    KP-102-induced stimulation of food intake was observed in freely-fed rats but not in 24-h starved rats.
    1 context sentence
    Summary · context
    The effects of fasting, restraint stress, and intracerebroventricular (i.c.v.) injection of somatostatin on the growth hormone secretagogue, KP-102-induced stimulation of food intake were examined in rats.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats, intracerebroventricular KP-102 counteracted the reduction in food intake caused by 90 min of restraint stress.

    In plain wordsIn rats, KP-102 given into the brain offset the drop in eating caused by restraint stress.

    Peptide
    GHRP-2
    Outcome
    IncreaseFood intake after restraint stress
    Study

    ratn: not reported in source

    Rats
    Comparator
    Restraint stress without KP-102
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    Dose not stated · intracerebroventricularAs given in this study (rat).

    Source sentences

    Summary
    A 90 min period of restraint stress decreased food intake, and i.c.v. administration of KP-102 counteracted the suppressive effect of restraint on food intake.
    1 context sentence
    Summary · context
    The effects of fasting, restraint stress, and intracerebroventricular (i.c.v.) injection of somatostatin on the growth hormone secretagogue, KP-102-induced stimulation of food intake were examined in rats.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In freely-fed rats, intracerebroventricular somatostatin partially attenuated the stimulation of food intake by KP-102.

    In plain wordsIn freely-fed rats, somatostatin given into the brain partly reduced the extra eating caused by KP-102.

    Peptide
    GHRP-2
    Outcome
    MixedKP-102-induced food intake with somatostatin
    Study

    ratn: not reported in source

    Rats
    Comparator
    KP-102 without somatostatin
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    Dose not stated · intracerebroventricularAs given in this study (rat).

    Source sentences

    Summary
    I.c.v. administration of somatostatin partially attenuated the KP-102-induced stimulation of food intake in freely-fed rats, while somatostatin itself did not change food intake.
    1 context sentence
    Summary · context
    The effects of fasting, restraint stress, and intracerebroventricular (i.c.v.) injection of somatostatin on the growth hormone secretagogue, KP-102-induced stimulation of food intake were examined in rats.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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