In busulfan-treated recipient mice, leuprolide enhanced donor cell colonization versus untreated controls, assessed 3 months after transplantation.
In plain wordsIn mice, leuprolide enhanced donor cell colonization versus untreated controls at assessment 3 months after transplantation.
- Peptide
- Leuprolide
- Outcome
- IncreaseDonor cell colonization
- Study
mousen = 6
Busulfan-treated recipient mice undergoing spermatogonial transplantation- Comparator
- Untreated control mice
- Outcome group
- Sex hormones and fertility · Reproductive and sexual health
- Studied dose
- Dose not stated · injectionAs given in this study (mouse).
Source sentences
Efficiency of colonization by donor cells was markedly enhanced in recipient mice treated with the GnRH agonist leuprolide acetate,
2 context sentences(design, population, supporting numbers)
Six recipient mice were treated with busulfan to destroy endogenous spermatogenesis followed by injection of leuprolide acetate to three of the mice.
The extent of donor cell colonization was compared between leuprolide treated recipients and untreated control mice 3 months after transplantation.