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Study · Animal study (in vivo) · rat · 1997

3 results

The novel substituted acylproline-containing dipeptide, GVS-111, promotes the restoration of learning and memory impaired by bilateral frontal lobectomy in rats.

Ostrovskaya RU, Romanova GA, Trofimov SS, Gudasheva TA, Voronina TA, Halikas JA, Seredenin SB

Behavioural pharmacology1 Jun 1997Cited by 6 (Europe PMC)

PMID9833021 (opens in a new tab)PepBankPUB-09833021
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats with bilateral frontal lobectomy, GVS-111 improved active avoidance performance.

    In plain wordsIn rats with frontal brain surgery, GVS-111 improved active avoidance performance.

    Peptide
    Noopept (omberacetam)
    Outcome
    IncreaseActive avoidance performance
    Study

    ratn: not reported in source

    Bilateral frontal lobectomy
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    0.5 mg/kg/day · intraperitoneal · 9 days following operationAs given in this study (rat).

    Source sentences

    Summary
    GVS-111, administered in a dose of 0.5 mg/kg/day i.p. for 9 days following the operation, was found to improve performance in both active avoidance and passive avoidance and restored habituation of horizontal activity in the lobectomized animals.
    1 context sentence
    Summary · context
    The present study investigated the potential benefit of the ethyl ester of N-phenylacetylprolylglycine (GVS-111) on the model of bilateral frontal lobectomy (BFL) in rats.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats with bilateral frontal lobectomy, GVS-111 improved passive avoidance performance.

    In plain wordsIn rats with frontal brain surgery, GVS-111 improved passive avoidance performance.

    Peptide
    Noopept (omberacetam)
    Outcome
    IncreasePassive avoidance performance
    Study

    ratn: not reported in source

    Bilateral frontal lobectomy
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    0.5 mg/kg/day · intraperitoneal · 9 days following operationAs given in this study (rat).

    Source sentences

    Summary
    GVS-111, administered in a dose of 0.5 mg/kg/day i.p. for 9 days following the operation, was found to improve performance in both active avoidance and passive avoidance and restored habituation of horizontal activity in the lobectomized animals.
    1 context sentence
    Summary · context
    The present study investigated the potential benefit of the ethyl ester of N-phenylacetylprolylglycine (GVS-111) on the model of bilateral frontal lobectomy (BFL) in rats.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats with bilateral frontal lobectomy, GVS-111 restored habituation of horizontal activity.

    In plain wordsIn rats with frontal brain surgery, GVS-111 restored habituation of horizontal movement.

    Peptide
    Noopept (omberacetam)
    Outcome
    IncreaseHorizontal activity habituation
    Study

    ratn: not reported in source

    Bilateral frontal lobectomy
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    0.5 mg/kg/day · intraperitoneal · 9 days following operationAs given in this study (rat).

    Source sentences

    Summary
    GVS-111, administered in a dose of 0.5 mg/kg/day i.p. for 9 days following the operation, was found to improve performance in both active avoidance and passive avoidance and restored habituation of horizontal activity in the lobectomized animals.
    1 context sentence
    Summary · context
    The present study investigated the potential benefit of the ethyl ester of N-phenylacetylprolylglycine (GVS-111) on the model of bilateral frontal lobectomy (BFL) in rats.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

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