In cultured brain endothelial cells, Cerebrolysin reduced GLUT1 mRNA fractional turnover from 72.4 to 4.0%/h compared with control cells.
In plain wordsIn cells from brain blood vessels, Cerebrolysin reduced GLUT1 message turnover compared with control cells.
- Peptide
- Cerebrolysin
- Outcome
- DecreaseGLUT1 mRNA fractional turnover rate
- Study
n: not reported in source
Brain endothelial cultured cells transfected with human GLUT1 transcript- Comparator
- Control cells
- Outcome group
- Receptor activity and mechanism · Nervous system and cognition
- Studied dose
- Dose not stated
Measurements
- Fractional turnover rate
- 72.4 %/h
- Control
- Fractional turnover rate
- 4 %/h
- Cerebrolysin
Source sentences
On the contrary, the decay of the hGLUT1 mRNA was stabilized in CI-treated cells resulting in a marked reduction in the fractional turnover rate (72.4 and 4.0%/h, control and CI, respectively).
2 context sentences(design, population, supporting numbers)
The present investigation studied the effect of the brain-derived peptide preparation Cerebrolysin (CI, EBEWE, Austria) on the turnover rate and gene expression of the blood-brain barrier (BBB) GLUT1 glucose transporter mRNA.
Studies were performed in brain endothelial cultured cells transfected with the human (h) GLUT1 transcript.