In hypercholesterolemic rabbits, thymosin alpha1 significantly decreased plasma TBARS levels.
In plain wordsIn rabbits with high cholesterol, thymosin alpha‑1 lowered a blood marker of fat oxidation.
- Peptide
- Thymosin alpha-1
- Outcome
- DecreasePlasma TBARS (lipid peroxide) levels
- Study
rabbitn: not reported in source
rabbits with diet-induced hypercholesterolemia- Comparator
- Hypercholesterolemic rabbits on normal diet without peptide
- Outcome group
- Lipids · Cardiovascular
- Studied dose
- 25 microg/kg every other day · intraperitoneal · 14 daysAs given in this study (rabbit).
Source sentences
Plasma and erythrocyte TBARS levels significantly decreased in the thymosin-alpha1-injected rabbits.
3 context sentences(design, population, supporting numbers)
Hypercholesterolemic rabbits had high plasma and erythrocyte lipid peroxide (TBARS) levels compared to control animals fed a normal diet.
In groups II-IV, rabbits were fed a high-cholesterol diet 2% (w/w) for 10 weeks.
Thereafter, rabbits in group III were fed a normal diet for another 14 days and those in group IV were given a normal diet plus 25 microg/kg thymosin alpha1 intraperitoneally every other day for the same period.