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Study · Animal study (in vivo) · rat · 1998

3 results

Delta-sleep-inducing peptide and its analogs and the serotoninergic system in the development of anticonvulsive influences.

Shandra AA, Godlevskii LS, Brusentsov AI, Petrashevich VP, Vast'yanov RS, Nikel B, Mikhaleva II

Neuroscience and behavioral physiology1 Sept 1998Cited by 2 (Europe PMC)

PMID9809291 (opens in a new tab)DOI10.1007/bf02463012 (opens in a new tab)PepBankPUB-09809291
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats, intranigral and intrahippocampal microinjections of DSIP and its analogs had anticonvulsant effects against picrotoxin-induced epileptic activity.

    In plain wordsIn rats, DSIP and its analogs injected into the brain reduced seizure activity caused by picrotoxin.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    DecreasePicrotoxin-induced epileptic activity
    Study

    ratn: not reported in source

    picrotoxin- and kainate-induced epileptic activity
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated · intranigral and intrahippocampal microinjectionAs given in this study (rat).

    Source sentences

    Summary
    Intranigral and intrahippocampal microinjections of peptide and its analogs were found to have anticonvulsant effects against both picrotoxin- and kainate-induced epileptic activity.
    1 context sentence
    Summary · context
    Experiments on rats were carried out to study the effects of administration of delta-sleep-inducing peptide (DSIP) and its analogs (9-14) into the reticular part of the substantia nigra and ventral hippocampus on picrotoxin- and kainate-induced epileptic activity.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats, intranigral and intrahippocampal microinjections of DSIP and its analogs had anticonvulsant effects against kainate-induced epileptic activity.

    In plain wordsIn rats, DSIP and its analogs injected into the brain reduced seizure activity caused by kainate.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    DecreaseKainate-induced epileptic activity
    Study

    ratn: not reported in source

    picrotoxin- and kainate-induced epileptic activity
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated · intranigral and intrahippocampal microinjectionAs given in this study (rat).

    Source sentences

    Summary
    Intranigral and intrahippocampal microinjections of peptide and its analogs were found to have anticonvulsant effects against both picrotoxin- and kainate-induced epileptic activity.
    1 context sentence
    Summary · context
    Experiments on rats were carried out to study the effects of administration of delta-sleep-inducing peptide (DSIP) and its analogs (9-14) into the reticular part of the substantia nigra and ventral hippocampus on picrotoxin- and kainate-induced epileptic activity.

Studies that did not test the peptide alone1

In this study, Delta sleep-inducing peptide (DSIP) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Delta sleep-inducing peptide (DSIP).

  1. 03AnimalNot a test of Delta sleep-inducing peptide (DSIP) aloneAnimal study (in vivo)Mechanism

    In rats, DSIP and its structural analogs predominantly increased uptake of tryptophan by brain structures.

    In plain wordsIn rats, DSIP and its related peptides mostly raised tryptophan uptake in brain areas.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseBrain tryptophan uptake
    Study

    ratn: not reported in source

    picrotoxin- and kainate-induced epileptic activity
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition

    Source sentences

    Summary
    Studies of the effects of DSIP and its structural analogs on the uptake of tryptophan by brain structures showed that peptides predominantly increased uptake of this amino acid.
    1 context sentence
    Summary · context
    Experiments on rats were carried out to study the effects of administration of delta-sleep-inducing peptide (DSIP) and its analogs (9-14) into the reticular part of the substantia nigra and ventral hippocampus on picrotoxin- and kainate-induced epileptic activity.

    In this study, Delta sleep-inducing peptide (DSIP) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Delta sleep-inducing peptide (DSIP).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 08:55 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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