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Study · In vitro (cells) · rat · 1998

4 results

Growth hormone-releasing peptide-2 (GHRP-2) does not act via the human growth hormone-releasing factor receptor in GC cells.

Chen C, Farnworth P, Petersenn S, Musgrave I, Canny BJ, Clarke IJ

Endocrine1 Aug 1998Cited by 3 (Europe PMC)

PMID9798733 (opens in a new tab)DOI10.1385/endo:9:1:71 (opens in a new tab)PepBankPUB-09798733
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In rat GC/R- pituitary cells, GHRP‑2 up to 10(-7)M did not alter intracellular cAMP.

    In plain wordsIn rat pituitary cells without the GRF receptor, GHRP‑2 did not change cAMP inside the cells.

    Peptide
    GHRP-2
    Outcome
    No significant changeIntracellular cAMP in GC/R- cells
    Study

    ratn: not reported in source

    Rat pituitary GC cells lacking GRF receptor (GC/R-) or transfected with human GRF receptor (GC/R+)
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    up to 10(-7)MAs given in this study (rat).

    Source sentences

    Summary
    In GC/R- cells, incubation with up to 10(-7)M of either hGRF or GHRP-2 did not alter the intracellular cAMP, [Ca2+]i, or GH secretion.
    1 context sentence
    Summary · context
    In the present study, we used rat pituitary GC cells with or without stable transfection of cDNA coding for the human GRF receptor (GC/R+ or GC/R-) to determine whether or not GHRP-2 acts via the GRF receptor.
  2. 02LabIn vitro (cells)Mechanism

    In rat GC/R- pituitary cells, GHRP‑2 up to 10(-7)M did not alter intracellular calcium.

    In plain wordsIn rat pituitary cells without the GRF receptor, GHRP‑2 did not change calcium inside the cells.

    Peptide
    GHRP-2
    Outcome
    No significant changeIntracellular Ca2+ in GC/R- cells
    Study

    ratn: not reported in source

    Rat pituitary GC cells lacking GRF receptor (GC/R-) or transfected with human GRF receptor (GC/R+)
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    up to 10(-7)MAs given in this study (rat).

    Source sentences

    Summary
    In GC/R- cells, incubation with up to 10(-7)M of either hGRF or GHRP-2 did not alter the intracellular cAMP, [Ca2+]i, or GH secretion.
    1 context sentence
    Summary · context
    In the present study, we used rat pituitary GC cells with or without stable transfection of cDNA coding for the human GRF receptor (GC/R+ or GC/R-) to determine whether or not GHRP-2 acts via the GRF receptor.
  3. 03LabIn vitro (cells)Activity measurement

    In rat GC/R- pituitary cells, GHRP‑2 up to 10(-7)M did not alter GH secretion.

    In plain wordsIn rat pituitary cells without the GRF receptor, GHRP‑2 did not change growth hormone release.

    Peptide
    GHRP-2
    Outcome
    No significant changeGH secretion in GC/R- cells
    Study

    ratn: not reported in source

    Rat pituitary GC cells lacking GRF receptor (GC/R-) or transfected with human GRF receptor (GC/R+)
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    up to 10(-7)MAs given in this study (rat).

    Source sentences

    Summary
    In GC/R- cells, incubation with up to 10(-7)M of either hGRF or GHRP-2 did not alter the intracellular cAMP, [Ca2+]i, or GH secretion.
    1 context sentence
    Summary · context
    In the present study, we used rat pituitary GC cells with or without stable transfection of cDNA coding for the human GRF receptor (GC/R+ or GC/R-) to determine whether or not GHRP-2 acts via the GRF receptor.
  4. 04LabIn vitro (cells)Mechanism

    In GC/R+ cells expressing the human GRF receptor, GHRP‑2 did not modify intracellular cAMP, which suggests that GHRP‑2 does not act through the GRF receptor.

    In plain wordsIn rat pituitary cells carrying the human GRF receptor, GHRP‑2 did not change cAMP, so it seems not to act through that receptor.

    Peptide
    GHRP-2
    Outcome
    No significant changeIntracellular cAMP in GC/R+ cells transfected with human GRF receptor
    Study

    ratn: not reported in source

    Rat pituitary GC cells lacking GRF receptor (GC/R-) or transfected with human GRF receptor (GC/R+)
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    10(-1)-10(-8)MAs given in this study (rat).

    Source sentences

    Summary
    Incubation of the transfected cells with 10(-1)-10(-8)MGH RP-2 did not modify intracellular cAMP levels.
    2 context sentences
    Summary · context
    This result suggests that GHRP-2 does not act through the GRF receptor.
    Summary · context
    In the present study, we used rat pituitary GC cells with or without stable transfection of cDNA coding for the human GRF receptor (GC/R+ or GC/R-) to determine whether or not GHRP-2 acts via the GRF receptor.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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