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Study · Animal study (in vivo) · rat · 1998

5 results

[Short-term effects of septo-hippocampal pathway transsection and cerebrolysin effects on glutathione-related enzymes in the rat brain].

Cruz R, Francis L, Díaz-Suárez CM, González-Fraguela ME

Revista de neurologia1 Apr 1998Cited by 4 (Europe PMC)

PMID9796003 (opens in a new tab)DOI10.33588/rn.26152.98025 (opens in a new tab)PepBankPUB-09796003
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In fimbria-fornix-lesioned rats, Cerebrolysin pretreatment did not modify hippocampal glutathione S-transferase activity.

    In plain wordsIn lesioned rats, Cerebrolysin did not change hippocampal glutathione S-transferase activity compared with saline.

    Peptide
    Cerebrolysin
    Outcome
    No significant changeHippocampal glutathione S-transferase activity
    Study

    ratn: not reported in source

    Fimbria-fornix lesion
    Comparator
    Physiological saline
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    2.5 ml/kg daily · intraperitoneally · one weekAs given in this study (rat).

    Source sentences

    Summary
    Pretreatment with Cerebrolysin did not modify the enzymes in FF-lesioned rats
    3 context sentences
    Summary · context
    Twenty four hours after the lesion was produced, the activity of the enzymes glutathione S-transferase (GST), glutathione reductase (GRD) and glutathione peroxidase were measured in various cerebral areas.
    Summary · context
    The lesion caused reduced activity of the three enzymes in the hippocampus, and also in the activity of striatal GRD.
    Summary · context
    Four groups of rats were studied: Healthy, treated with physiological saline; healthy treated with Cerebrolysin (2.5 ml/kg daily for one week, intraperitoneally); FF-lesioned and pretreated with physiological saline, and with lesions and pretreated with Cerebrolysin.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In fimbria-fornix-lesioned rats, Cerebrolysin pretreatment did not modify hippocampal glutathione reductase activity.

    In plain wordsIn lesioned rats, Cerebrolysin did not change hippocampal glutathione reductase activity compared with saline.

    Peptide
    Cerebrolysin
    Outcome
    No significant changeHippocampal glutathione reductase activity
    Study

    ratn: not reported in source

    Fimbria-fornix lesion
    Comparator
    Physiological saline
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    2.5 ml/kg daily · intraperitoneally · one weekAs given in this study (rat).

    Source sentences

    Summary
    Pretreatment with Cerebrolysin did not modify the enzymes in FF-lesioned rats
    3 context sentences
    Summary · context
    Twenty four hours after the lesion was produced, the activity of the enzymes glutathione S-transferase (GST), glutathione reductase (GRD) and glutathione peroxidase were measured in various cerebral areas.
    Summary · context
    The lesion caused reduced activity of the three enzymes in the hippocampus, and also in the activity of striatal GRD.
    Summary · context
    Four groups of rats were studied: Healthy, treated with physiological saline; healthy treated with Cerebrolysin (2.5 ml/kg daily for one week, intraperitoneally); FF-lesioned and pretreated with physiological saline, and with lesions and pretreated with Cerebrolysin.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In fimbria-fornix-lesioned rats, Cerebrolysin pretreatment did not modify hippocampal glutathione peroxidase activity.

    In plain wordsIn lesioned rats, Cerebrolysin did not change hippocampal glutathione peroxidase activity compared with saline.

    Peptide
    Cerebrolysin
    Outcome
    No significant changeHippocampal glutathione peroxidase activity
    Study

    ratn: not reported in source

    Fimbria-fornix lesion
    Comparator
    Physiological saline
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    2.5 ml/kg daily · intraperitoneally · one weekAs given in this study (rat).

    Source sentences

    Summary
    Pretreatment with Cerebrolysin did not modify the enzymes in FF-lesioned rats
    3 context sentences
    Summary · context
    Twenty four hours after the lesion was produced, the activity of the enzymes glutathione S-transferase (GST), glutathione reductase (GRD) and glutathione peroxidase were measured in various cerebral areas.
    Summary · context
    The lesion caused reduced activity of the three enzymes in the hippocampus, and also in the activity of striatal GRD.
    Summary · context
    Four groups of rats were studied: Healthy, treated with physiological saline; healthy treated with Cerebrolysin (2.5 ml/kg daily for one week, intraperitoneally); FF-lesioned and pretreated with physiological saline, and with lesions and pretreated with Cerebrolysin.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In fimbria-fornix-lesioned rats, Cerebrolysin pretreatment did not modify striatal glutathione reductase activity.

    In plain wordsIn lesioned rats, Cerebrolysin did not change striatal glutathione reductase activity compared with saline.

    Peptide
    Cerebrolysin
    Outcome
    No significant changeStriatal glutathione reductase activity
    Study

    ratn: not reported in source

    Fimbria-fornix lesion
    Comparator
    Physiological saline
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    2.5 ml/kg daily · intraperitoneally · one weekAs given in this study (rat).

    Source sentences

    Summary
    Pretreatment with Cerebrolysin did not modify the enzymes in FF-lesioned rats
    3 context sentences
    Summary · context
    The lesion caused reduced activity of the three enzymes in the hippocampus, and also in the activity of striatal GRD.
    Summary · context
    Four groups of rats were studied: Healthy, treated with physiological saline; healthy treated with Cerebrolysin (2.5 ml/kg daily for one week, intraperitoneally); FF-lesioned and pretreated with physiological saline, and with lesions and pretreated with Cerebrolysin.
    Summary · context
    Twenty four hours after the lesion was produced, the activity of the enzymes glutathione S-transferase (GST), glutathione reductase (GRD) and glutathione peroxidase were measured in various cerebral areas.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In healthy rats, Cerebrolysin reduced hippocampal glutathione S-transferase activity.

    In plain wordsIn healthy rats, Cerebrolysin reduced hippocampal glutathione S-transferase activity compared with saline.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseHippocampal glutathione S-transferase activity
    Study

    ratn: not reported in source

    Healthy rats
    Comparator
    Physiological saline
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    2.5 ml/kg daily · intraperitoneally · one weekAs given in this study (rat).

    Source sentences

    Summary
    Pretreatment with Cerebrolysin did not modify the enzymes in FF-lesioned rats, but did reduce the activity of hippocampal GST in healthy rats.
    2 context sentences
    Summary · context
    Four groups of rats were studied: Healthy, treated with physiological saline; healthy treated with Cerebrolysin (2.5 ml/kg daily for one week, intraperitoneally); FF-lesioned and pretreated with physiological saline, and with lesions and pretreated with Cerebrolysin.
    Summary · context
    Twenty four hours after the lesion was produced, the activity of the enzymes glutathione S-transferase (GST), glutathione reductase (GRD) and glutathione peroxidase were measured in various cerebral areas.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

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