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Study · Measured the body's own peptide · 1998

5 results

Effects of electroconvulsive therapy on plasma vasopressin and oxytocin.

Devanand DP, Lisanby S, Lo ES, Fitzsimons L, Cooper TB, Halbreich U, Sackeim HA

Biological psychiatry1 Oct 1998Cited by 23 (Europe PMC)

PMID9787885 (opens in a new tab)DOI10.1016/s0006-3223(98)00086-9 (opens in a new tab)PepBankPUB-09787885
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study5

No result from this study comes from a test of the peptide.

Natural levels measured5

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01HumanEndogenous levelRandomized controlled trialOther

    In medication-free patients with major depression receiving ECT, the surge in the body's own plasma oxytocin at the second and ninth ECT was not associated with clinical improvement.

    In plain wordsIn depressed patients having ECT, the rise in the body's own oxytocin was not linked to clinical improvement.

    Peptide
    Oxytocin
    Outcome
    No significant changeAssociation of oxytocin surge with clinical improvement
    Study

    n = 55

    Outcome group
    Endogenous peptide levels · Mental health and mood

    Source sentences

    Summary
    At the second and ninth ECT treatments, the vasopressin or oxytocin surges were not associated with clinical improvement, seizure duration, time to orientation, or memory test performance.
    2 context sentences
    Summary · context
    Medication-free patients with major depression were randomized to receive right unilateral or bilateral ECT administered with electrical stimulus intensity at either just above seizure threshold or at 150% above seizure threshold.
    Summary · context
    The sample comprised 55 patients.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  2. 02HumanEndogenous levelRandomized controlled trialOther

    In medication-free patients with major depression receiving ECT, the surge in the body's own plasma oxytocin was not associated with seizure duration.

    In plain wordsIn depressed patients having ECT, the rise in the body's own oxytocin was not linked to how long the seizure lasted.

    Peptide
    Oxytocin
    Outcome
    No significant changeAssociation of oxytocin surge with seizure duration
    Study

    n = 55

    Outcome group
    Seizures · Nervous system and cognition

    Source sentences

    Summary
    At the second and ninth ECT treatments, the vasopressin or oxytocin surges were not associated with clinical improvement, seizure duration, time to orientation, or memory test performance.
    2 context sentences
    Summary · context
    Medication-free patients with major depression were randomized to receive right unilateral or bilateral ECT administered with electrical stimulus intensity at either just above seizure threshold or at 150% above seizure threshold.
    Summary · context
    The sample comprised 55 patients.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  3. 03HumanEndogenous levelRandomized controlled trialOther

    In medication-free patients with major depression receiving ECT, the surge in the body's own plasma oxytocin was not associated with time to orientation.

    In plain wordsIn depressed patients having ECT, the rise in the body's own oxytocin was not linked to time to regain orientation.

    Peptide
    Oxytocin
    Outcome
    No significant changeAssociation of oxytocin surge with time to orientation
    Study

    n = 55

    Outcome group
    Cognition and memory · Nervous system and cognition

    Source sentences

    Summary
    At the second and ninth ECT treatments, the vasopressin or oxytocin surges were not associated with clinical improvement, seizure duration, time to orientation, or memory test performance.
    2 context sentences
    Summary · context
    Medication-free patients with major depression were randomized to receive right unilateral or bilateral ECT administered with electrical stimulus intensity at either just above seizure threshold or at 150% above seizure threshold.
    Summary · context
    The sample comprised 55 patients.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  4. 04HumanEndogenous levelRandomized controlled trialOther

    In medication-free patients with major depression receiving ECT, the surge in the body's own plasma oxytocin was not associated with memory test performance.

    In plain wordsIn depressed patients having ECT, the rise in the body's own oxytocin was not linked to memory test results.

    Peptide
    Oxytocin
    Outcome
    No significant changeAssociation of oxytocin surge with memory test performance
    Study

    n = 55

    Outcome group
    Cognition and memory · Nervous system and cognition

    Source sentences

    Summary
    At the second and ninth ECT treatments, the vasopressin or oxytocin surges were not associated with clinical improvement, seizure duration, time to orientation, or memory test performance.
    2 context sentences
    Summary · context
    Medication-free patients with major depression were randomized to receive right unilateral or bilateral ECT administered with electrical stimulus intensity at either just above seizure threshold or at 150% above seizure threshold.
    Summary · context
    The sample comprised 55 patients.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  5. 05HumanEndogenous levelRandomized controlled trialOther

    In medication-free patients with major depression receiving ECT, a larger acute surge in the body's own plasma oxytocin at the ninth ECT showed an inverse trend-level association with clinical response.

    In plain wordsIn depressed patients having ECT, a bigger rise in the body's own oxytocin tended to go with less clinical response, though only as a trend.

    Peptide
    Oxytocin
    Outcome
    Not applicableAssociation of oxytocin surge at ninth ECT with clinical response
    Study

    n = 55

    Outcome group
    Endogenous peptide levels · Mental health and mood

    Source sentences

    Summary
    There were inverse trend-level associations between the acute surge in oxytocin levels at the ninth ECT and clinical response, contradicting a report in the literature.
    2 context sentences
    Summary · context
    Medication-free patients with major depression were randomized to receive right unilateral or bilateral ECT administered with electrical stimulus intensity at either just above seizure threshold or at 150% above seizure threshold.
    Summary · context
    The sample comprised 55 patients.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:51 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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