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Study · Animal study (in vivo) · rat · 1998

3 results

Rat milk and dietary long arginine3 insulin-like growth factor I promote intestinal growth of newborn rat pups.

Staley MD, Gibson CA, Herbein JF, Grosvenor CE, Baumrucker CR

Pediatric research1 Oct 1998Cited by 12 (Europe PMC)

PMID9773839 (opens in a new tab)DOI10.1203/00006450-199810000-00008 (opens in a new tab)PepBankPUB-09773839
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In newborn rat pups, dietary long R3 IGF-I increased intestinal villi height compared with rat milk replacer, with the greatest increase among the groups.

    In plain wordsIn newborn rats, food containing long R3 IGF-I made gut villi taller than milk replacer alone.

    Peptide
    IGF-1 LR3
    Outcome
    IncreaseIntestinal villus height
    Study

    ratn: not reported in source

    newborn rat pups reared by the pup in cup method
    Comparator
    Rat milk replacer
    Outcome group
    Intestinal growth and absorption · Gastrointestinal
    Studied dose
    Dose not stated · dietaryAs given in this study (rat).

    Source sentences

    Summary
    Mother-fed (MF) controls and long R3 IGF-I-fed pups showed increased villi height and cell counts when compared with RMR pups, with long R3 IGF-I fed pups showing the greatest increase.
    1 context sentence
    Summary · context
    Newborn rat pups were artificially reared by the pup in cup (PIC) method to determine whether dietary long arginine3 IGF-I (long R3 IGF-I), an IGF-I analog with high receptor affinity and low IGF binding protein (IGFBP) affinity, had efficacy on intestinal growth.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In newborn rat pups, dietary long R3 IGF-I increased intestinal cell counts compared with rat milk replacer, with the greatest increase among the groups.

    In plain wordsIn newborn rats, food containing long R3 IGF-I increased gut cell numbers compared with milk replacer alone.

    Peptide
    IGF-1 LR3
    Outcome
    IncreaseIntestinal cell counts
    Study

    ratn: not reported in source

    newborn rat pups reared by the pup in cup method
    Comparator
    Rat milk replacer
    Outcome group
    Intestinal growth and absorption · Gastrointestinal
    Studied dose
    Dose not stated · dietaryAs given in this study (rat).

    Source sentences

    Summary
    Mother-fed (MF) controls and long R3 IGF-I-fed pups showed increased villi height and cell counts when compared with RMR pups, with long R3 IGF-I fed pups showing the greatest increase.
    1 context sentence
    Summary · context
    Newborn rat pups were artificially reared by the pup in cup (PIC) method to determine whether dietary long arginine3 IGF-I (long R3 IGF-I), an IGF-I analog with high receptor affinity and low IGF binding protein (IGFBP) affinity, had efficacy on intestinal growth.

Studies that did not test the peptide alone1

In this study, IGF-1 LR3 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking IGF-1 LR3.

  1. 03AnimalNot a test of IGF-1 LR3 aloneAnimal study (in vivo)Mechanism

    In newborn rat pups, the decline of intestinal IGFBP-3 message over time was not influenced by the dietary treatments.

    In plain wordsIn newborn rats, the diets tested did not change how IGFBP-3 message in the gut fell over time.

    Peptide
    IGF-1 LR3
    Outcome
    No significant changeIntestinal IGFBP-3 message over time
    Study

    ratn: not reported in source

    newborn rat pups reared by the pup in cup method
    Outcome group
    Receptor activity and mechanism · Gastrointestinal

    Source sentences

    Summary
    Northern analysis of IGFBP-3 message showed a decline over time, but the change was not influenced by dietary treatments.
    1 context sentence
    Summary · context
    Newborn rat pups were artificially reared by the pup in cup (PIC) method to determine whether dietary long arginine3 IGF-I (long R3 IGF-I), an IGF-I analog with high receptor affinity and low IGF binding protein (IGFBP) affinity, had efficacy on intestinal growth.

    In this study, IGF-1 LR3 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking IGF-1 LR3.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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