Growth hormone (GH) response to GH-releasing peptide-6 in type 1 diabetic patients with exaggerated GH-releasing hormone-stimulated GH secretion.

Catalina PF, Mallo F, Mallo F, Andrade MA, García-Mayor RV, Diéguez C

The Journal of clinical endocrinology and metabolism1 Oct 1998Cited by 7 (Europe PMC)

PMID9768681DOI10.1210/jcem.83.10.5153PepBankPUB-09768681

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

1 result from studies that gave the peptide. 1 result from people.

01HumanNon-randomized trialActivity measurement
After GHRP‑6, GH peaks were higher in men with type 1 diabetes than in matched controls.
In plain wordsAfter GHRP‑6, men with type 1 diabetes had higher growth hormone peaks than matched controls.
Peptide
GHRP-6
Outcome
IncreaseGH peak after GHRP-6
Study
n = 12
Comparator
Matched healthy volunteers
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
90 microg · intravenousAs given in this study (human).
Measurements
GH peak
66.2 microg/L
diabetes
GH peak
39.9 microg/L
controls
Source sentences
Summary
GH peak values were higher in DM 1 patients than in control volunteers, after GHRH (52.2+/-9.8 vs. 19.3+/-6.0 microg/L; P = 0.016), GHRP-6 (66.2+/-9.6 vs. 39.9+/-6.3 microg/L; P = 0.05), and GHRH plus GHRP-6 (81.8+/-4.4 vs. 53.7+/-8.2 microg/L; P = 0.01).
2 context sentences(design, population, supporting numbers)
Summary · context
Six type 1 diabetic males and six age-, sex-, and body mass index-matched control volunteers were studied.
Summary · context
Each subject received GHRH (100 microg iv), GHRP-6 (90 microg iv), and GHRH plus GHRP-6 on three separate days.
Report a problemFND-0976868101

Studies that did not test the peptide alone2

In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking GHRP-6.

02HumanNot a test of GHRP-6 aloneNon-randomized trialActivity measurement
After GHRH plus GHRP‑6, GH peaks were higher in diabetic men than in controls.
In plain wordsAfter GHRH plus GHRP‑6, diabetic men had higher growth hormone peaks than controls.
Peptide
GHRP-6
Outcome
IncreaseGH peak after GHRH plus GHRP-6
Study
n = 12
Comparator
Matched healthy volunteers
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Measurements
GH peak
81.8 microg/L
diabetes
GH peak
53.7 microg/L
controls
Source sentences
Summary
GH peak values were higher in DM 1 patients than in control volunteers, after GHRH (52.2+/-9.8 vs. 19.3+/-6.0 microg/L; P = 0.016), GHRP-6 (66.2+/-9.6 vs. 39.9+/-6.3 microg/L; P = 0.05), and GHRH plus GHRP-6 (81.8+/-4.4 vs. 53.7+/-8.2 microg/L; P = 0.01).
2 context sentences(design, population, supporting numbers)
Summary · context
Six type 1 diabetic males and six age-, sex-, and body mass index-matched control volunteers were studied.
Summary · context
Each subject received GHRH (100 microg iv), GHRP-6 (90 microg iv), and GHRH plus GHRP-6 on three separate days.
In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.
Report a problemFND-0976868102
03HumanNot a test of GHRP-6 aloneNon-randomized trialActivity measurement
In diabetic men, GHRH plus GHRP‑6 produced an additive GH response.
In plain wordsIn diabetic men, GHRH plus GHRP‑6 produced an additive growth hormone response.
Peptide
GHRP-6
Outcome
IncreaseAdditive GH response
Study
n = 6
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Source sentences
Summary
An additive GH response to combined administration of these two peptides was observed in diabetic patients.
2 context sentences(design, population, supporting numbers)
Summary · context
Six type 1 diabetic males and six age-, sex-, and body mass index-matched control volunteers were studied.
Summary · context
Each subject received GHRH (100 microg iv), GHRP-6 (90 microg iv), and GHRH plus GHRP-6 on three separate days.
In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.
Report a problemFND-0976868103

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
21 Oct 2026, 15:58 UTC
Study results updated
Version 1
9 Oct 2026, 03:13 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

MeSH terms

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