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Study · In vitro (cells) · 1998

6 results

Growth hormone-releasing hexapeptide (GHRP-6) increases intracellular calcium concentrations in cultured cells from human pituitary adenomas of different types.

Lania A, Ballaré E, Corbetta S, Filopanti M, Persani L, Spada A

European journal of endocrinology1 Sept 1998Cited by 8 (Europe PMC)

PMID9758447 (opens in a new tab)DOI10.1530/eje.0.1390343 (opens in a new tab)PepBankPUB-09758447
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Activity measurement

    In cultured GH-secreting adenomas, GHRP‑6 increased intracellular calcium.

    In plain wordsIn cells from GH-secreting tumors, GHRP‑6 increased internal calcium.

    Peptide
    GHRP-6
    Outcome
    IncreaseIntracellular calcium in GH-secreting adenomas
    Study

    humann: not reported in source

    Cultured human pituitary adenoma cells
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    >1 nmol/lAs given in this study (human).

    Source sentences

    Summary
    GHRP-6, at concentrations higher than 1 nmol/l, significantly increased [Ca2+]i in all tumours, with the exception of the 3 ACTH-secreting adenomas in which the peptide was ineffective at any concentration tested (from 1 nmol/l to 1 micromol/l).
    1 context sentence
    Summary · context
    The effect opf GHRP-6 on [Ca2+]i was tested in cell preparations obtained from a series of human pituitary adenomas (9 GH-secreting adenomas, 7 nonfunctioning adenomas, 3 ACTH-secreting adenomas, 2 TSH-secreting adenomas and 1 prolactinoma) loaded with the Ca2+ indicator fura-2.
  2. 02LabIn vitro (cells)Activity measurement

    In cultured nonfunctioning adenomas, GHRP‑6 increased intracellular calcium.

    In plain wordsIn cells from nonfunctioning tumors, GHRP‑6 increased internal calcium.

    Peptide
    GHRP-6
    Outcome
    IncreaseIntracellular calcium in nonfunctioning adenomas
    Study

    humann: not reported in source

    Cultured human pituitary adenoma cells
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    >1 nmol/lAs given in this study (human).

    Source sentences

    Summary
    GHRP-6, at concentrations higher than 1 nmol/l, significantly increased [Ca2+]i in all tumours, with the exception of the 3 ACTH-secreting adenomas in which the peptide was ineffective at any concentration tested (from 1 nmol/l to 1 micromol/l).
    1 context sentence
    Summary · context
    The effect opf GHRP-6 on [Ca2+]i was tested in cell preparations obtained from a series of human pituitary adenomas (9 GH-secreting adenomas, 7 nonfunctioning adenomas, 3 ACTH-secreting adenomas, 2 TSH-secreting adenomas and 1 prolactinoma) loaded with the Ca2+ indicator fura-2.
  3. 03LabIn vitro (cells)Activity measurement

    In cultured TSH-secreting adenomas, GHRP‑6 increased intracellular calcium.

    In plain wordsIn cells from TSH-secreting tumors, GHRP‑6 increased internal calcium.

    Peptide
    GHRP-6
    Outcome
    IncreaseIntracellular calcium in TSH-secreting adenomas
    Study

    humann: not reported in source

    Cultured human pituitary adenoma cells
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    >1 nmol/lAs given in this study (human).

    Source sentences

    Summary
    GHRP-6, at concentrations higher than 1 nmol/l, significantly increased [Ca2+]i in all tumours, with the exception of the 3 ACTH-secreting adenomas in which the peptide was ineffective at any concentration tested (from 1 nmol/l to 1 micromol/l).
    1 context sentence
    Summary · context
    The effect opf GHRP-6 on [Ca2+]i was tested in cell preparations obtained from a series of human pituitary adenomas (9 GH-secreting adenomas, 7 nonfunctioning adenomas, 3 ACTH-secreting adenomas, 2 TSH-secreting adenomas and 1 prolactinoma) loaded with the Ca2+ indicator fura-2.
  4. 04LabIn vitro (cells)Activity measurement

    In cultured prolactinoma cells, GHRP‑6 increased intracellular calcium.

    In plain wordsIn cells from a prolactin-secreting tumor, GHRP‑6 increased internal calcium.

    Peptide
    GHRP-6
    Outcome
    IncreaseIntracellular calcium in prolactinoma
    Study

    humann: not reported in source

    Cultured human pituitary adenoma cells
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    >1 nmol/lAs given in this study (human).

    Source sentences

    Summary
    GHRP-6, at concentrations higher than 1 nmol/l, significantly increased [Ca2+]i in all tumours, with the exception of the 3 ACTH-secreting adenomas in which the peptide was ineffective at any concentration tested (from 1 nmol/l to 1 micromol/l).
    1 context sentence
    Summary · context
    The effect opf GHRP-6 on [Ca2+]i was tested in cell preparations obtained from a series of human pituitary adenomas (9 GH-secreting adenomas, 7 nonfunctioning adenomas, 3 ACTH-secreting adenomas, 2 TSH-secreting adenomas and 1 prolactinoma) loaded with the Ca2+ indicator fura-2.
  5. 05LabIn vitro (cells)Activity measurement

    In cultured ACTH-secreting adenomas, GHRP‑6 did not increase intracellular calcium at any tested concentration.

    In plain wordsIn cells from ACTH-secreting tumors, GHRP‑6 did not increase internal calcium.

    Peptide
    GHRP-6
    Outcome
    No significant changeIntracellular calcium in ACTH-secreting adenomas
    Study

    humann: not reported in source

    Cultured human pituitary adenoma cells
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    1 nmol/l to 1 micromol/lAs given in this study (human).

    Source sentences

    Summary
    GHRP-6, at concentrations higher than 1 nmol/l, significantly increased [Ca2+]i in all tumours, with the exception of the 3 ACTH-secreting adenomas in which the peptide was ineffective at any concentration tested (from 1 nmol/l to 1 micromol/l).
    1 context sentence
    Summary · context
    The effect opf GHRP-6 on [Ca2+]i was tested in cell preparations obtained from a series of human pituitary adenomas (9 GH-secreting adenomas, 7 nonfunctioning adenomas, 3 ACTH-secreting adenomas, 2 TSH-secreting adenomas and 1 prolactinoma) loaded with the Ca2+ indicator fura-2.
  6. 06LabIn vitro (cells)Mechanism

    In responsive adenoma cells, GHRP‑6 caused biphasic calcium rises through intracellular mobilization and voltage-dependent calcium influx.

    In plain wordsIn responsive tumor cells, GHRP‑6 raised calcium through release from internal stores and entry through calcium channels.

    Peptide
    GHRP-6
    Outcome
    IncreaseCalcium mobilization and influx
    Study

    humann: not reported in source

    Cultured human pituitary adenoma cells
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In tumours responsive to GHRP-6, the peptide caused a typical biphasic [Ca2+]i rise due to Ca2+ mobilization from the intracellular stores and Ca2+ influx through voltage-dependent Ca2+ channels.
    1 context sentence
    Summary · context
    The effect opf GHRP-6 on [Ca2+]i was tested in cell preparations obtained from a series of human pituitary adenomas (9 GH-secreting adenomas, 7 nonfunctioning adenomas, 3 ACTH-secreting adenomas, 2 TSH-secreting adenomas and 1 prolactinoma) loaded with the Ca2+ indicator fura-2.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:13 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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