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Study · Non-randomized trial · n = 7 · 1998

3 results

Oxytocin enhances the prolactin response to vasoactive intestinal polypeptide in healthy women.

Chiodera P, Volpi R, Capretti L, Coiro V

Fertility and sterility1 Sept 1998Cited by 3 (Europe PMC)

PMID9757887 (opens in a new tab)DOI10.1016/s0015-0282(98)00202-7 (opens in a new tab)PepBankPUB-09757887
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

2 results from studies that gave the peptide. 2 results from people.

  1. 01HumanNon-randomized trialEfficacy outcome

    In healthy women, concurrent oxytocin significantly increased the prolactin response to VIP versus VIP alone (peak 2 times baseline).

    In plain wordsIn healthy women, giving oxytocin with VIP made the prolactin rise larger than VIP alone.

    Peptide
    Oxytocin
    Outcome
    IncreaseProlactin response to VIP with oxytocin
    Study

    n = 7

    Comparator
    VIP alone
    Outcome group
    Pituitary hormones · Endocrine and hormones
    Studied dose
    2 IU injected plus 0.07 IU/min infused for 60 minutes · 60 minutesAs given in this study (human).

    Measurements

    Mean peak prolactin response
    2 times baseline
    VIP plus oxytocin

    Source sentences

    Summary
    In the presence of oxytocin, the prolactin response to VIP was significantly higher, with a mean peak response 2 times higher than baseline.
    2 context sentences
    Summary · context
    Seven healthy women (aged 24-32 years) were tested on the 22nd day of two consecutive normal menstrual cycles.
    Summary · context
    Vasoactive intestinal polypeptide (4 pmol x kg(-1) x min(-1) in 50 mL of normal saline infused i.v. for 60 minutes) was administered in either the presence or absence of concurrent treatment with oxytocin (2 IU injected plus 0.07 IU/min infused for 60 minutes).
  2. 02HumanNon-randomized trialEfficacy outcome

    In healthy women, VIP infusion significantly increased serum prolactin, with a mean peak 1.6 times baseline at 45 minutes.

    In plain wordsIn healthy women, VIP infusion raised prolactin levels compared with baseline.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    IncreaseSerum prolactin response to VIP alone
    Study

    n = 7

    Comparator
    Baseline
    Outcome group
    Pituitary hormones · Endocrine and hormones
    Studied dose
    4 pmol x kg(-1) x min(-1) · intravenous · 60 minutesAs given in this study (human).

    Measurements

    Mean peak prolactin response
    1.6 times baseline
    VIP alone, 45 min

    Source sentences

    Summary
    The administration of VIP induced a significant increase in serum prolactin levels, with a mean peak response 1.6 times higher than baseline at 45 minutes after injection.
    2 context sentences
    Summary · context
    Seven healthy women (aged 24-32 years) were tested on the 22nd day of two consecutive normal menstrual cycles.
    Summary · context
    Vasoactive intestinal polypeptide (4 pmol x kg(-1) x min(-1) in 50 mL of normal saline infused i.v. for 60 minutes) was administered in either the presence or absence of concurrent treatment with oxytocin (2 IU injected plus 0.07 IU/min infused for 60 minutes).

Studies that did not test the peptide alone1

In this study, Vasoactive intestinal peptide (VIP, aviptadil) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Vasoactive intestinal peptide (VIP, aviptadil).

  1. 03HumanNot a test of Vasoactive intestinal peptide (VIP, aviptadil) aloneNon-randomized trialEfficacy outcome

    In healthy women, VIP given together with oxytocin produced a significantly higher prolactin response than VIP alone (peak 2 times baseline).

    In plain wordsIn healthy women, VIP plus oxytocin raised prolactin more than VIP alone.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    IncreaseProlactin response to VIP given with oxytocin
    Study

    n = 7

    Comparator
    VIP alone
    Outcome group
    Pituitary hormones · Endocrine and hormones

    Measurements

    Mean peak prolactin response
    2 times baseline
    VIP plus oxytocin

    Source sentences

    Summary
    In the presence of oxytocin, the prolactin response to VIP was significantly higher, with a mean peak response 2 times higher than baseline.
    2 context sentences
    Summary · context
    Seven healthy women (aged 24-32 years) were tested on the 22nd day of two consecutive normal menstrual cycles.
    Summary · context
    Vasoactive intestinal polypeptide (4 pmol x kg(-1) x min(-1) in 50 mL of normal saline infused i.v. for 60 minutes) was administered in either the presence or absence of concurrent treatment with oxytocin (2 IU injected plus 0.07 IU/min infused for 60 minutes).

    In this study, Vasoactive intestinal peptide (VIP, aviptadil) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Vasoactive intestinal peptide (VIP, aviptadil).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 12:41 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:51 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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