In men with adult-onset GH deficiency, GH replacement did not significantly change cognitive function after 18 months versus placebo.
In plain wordsIn men with adult-onset GH deficiency, GH did not significantly change cognitive function after 18 months compared with placebo.
- Peptide
- HGH (somatotropin)
- Outcome
- No significant changeCognitive function
- Study
n = 40
- Comparator
- Placebo
- Outcome group
- Cognition and memory · Nervous system and cognition
- Studied dose
- starting 10 +/- 0.3 micrograms/kg per day; mean 4 +/- 2 micrograms/kg per day · 18 monthsAs given in this study (human).
Source sentences
Following 18 months of GH replacement therapy, there were no significant changes in cognitive function or quality of life.
2 context sentences(design, population, supporting numbers)
We performed a randomized, double-blind, placebo-controlled study of GH replacement in adults with GHD and measured cognition and sense of well-being using standardized psychometric tests before and after therapy.
Forty men (median age 51 yr, range 24-64 yr) with a history of pituitary disease were randomized to GH therapy (starting dose, 10 +/- 0.3 micrograms/kg per day: mean treatment dose, 4 +/- 2 micrograms/kg per day) vs. placebo for 18 months, and GH doses were adjusted according to serum insulin growth factor-I levels.