Skip to content

Study · Randomized controlled trial · 1998

3 results

Leptin levels in protracted critical illness: effects of growth hormone-secretagogues and thyrotropin-releasing hormone.

Van den Berghe G, Wouters P, Carlsson L, Baxter RC, Bouillon R, Bowers CY

The Journal of clinical endocrinology and metabolism1 Sept 1998Cited by 21 (Europe PMC)

PMID9745404 (opens in a new tab)DOI10.1210/jcem.83.9.5120 (opens in a new tab)PepBankPUB-09745404
Publisher pagePubMedAsk about this study
Jump to 3 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

1 result from studies that gave the peptide. 1 result from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In critically ill adults, infusion of GHRP‑2 alone raised serum leptin by a maximum of 87% after 24 h.

    In plain wordsIn adults who were critically ill for several weeks, GHRP‑2 alone raised leptin in the blood by up to 87% after 24 hours.

    Peptide
    GHRP-2
    Outcome
    IncreaseSerum leptin with GHRP-2 alone
    Study

    n: not reported in source

    Outcome group
    Hormone levels · Endocrine and hormones
    Studied dose
    1 microgram/kg bolus then 1 microgram/kg.h · infusion · overnight infusion from 0900 h until 0600 hAs given in this study (human).

    Measurements

    maximal leptin increase
    87%
    GHRP-2 alone, after 24 h

    Source sentences

    Summary
    Infusion of GHRP-2 alone induced a maximal leptin increase of +87% after 24 h
    1 context sentence
    Summary · context
    Twenty adults, critically ill for several weeks and supported with normocaloric, continuously administered parenteral and/or enteral feeding, were studied for 45 h. They had been randomized to receive one of three combinations of peptide infusions, in random order: TRH (one day) and placebo (other d…

Studies that did not test the peptide alone2

In this study, GHRP-2 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking GHRP-2.

  1. 02HumanNot a test of GHRP-2 aloneRandomized controlled trialEfficacy outcome

    In critically ill adults, infusion of GHRH plus GHRP‑2 raised serum leptin by up to 157% after 24 h.

    In plain wordsIn adults who were critically ill for several weeks, GHRH and GHRP‑2 together raised leptin in the blood by up to 157% after 24 hours.

    Peptide
    GHRP-2
    Outcome
    IncreaseSerum leptin with GHRH plus GHRP-2
    Study

    n: not reported in source

    Outcome group
    Hormone levels · Endocrine and hormones

    Measurements

    maximal leptin increase
    157%
    GHRH + GHRP-2, after 24 h

    Source sentences

    Summary
    whereas GHRH + GHRP-2 elevated leptin by up to +157% after 24 h.
    1 context sentence
    Summary · context
    Twenty adults, critically ill for several weeks and supported with normocaloric, continuously administered parenteral and/or enteral feeding, were studied for 45 h. They had been randomized to receive one of three combinations of peptide infusions, in random order: TRH (one day) and placebo (other d…

    In this study, GHRP-2 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-2.

  2. 03HumanNot a test of GHRP-2 aloneRandomized controlled trialEfficacy outcome

    In critically ill adults, GH-secretagogues as a group (GHRP‑2 alone or with GHRH) elevated leptin within 12 h, while placebo or TRH had no effect.

    In plain wordsIn adults critically ill for weeks, growth hormone secretagogues as a group raised leptin within 12 hours, while placebo or TRH did not.

    Peptide
    GHRP-2
    Outcome
    IncreaseSerum leptin with GH-secretagogues pooled
    Study

    n: not reported in source

    Outcome group
    Hormone levels · Endocrine and hormones

    Source sentences

    Summary
    In contrast, GH-secretagogues elevated leptin levels within 12 h.
    2 context sentences
    Summary · context
    Infusion of placebo or TRH had no effect on leptin.
    Summary · context
    Twenty adults, critically ill for several weeks and supported with normocaloric, continuously administered parenteral and/or enteral feeding, were studied for 45 h. They had been randomized to receive one of three combinations of peptide infusions, in random order: TRH (one day) and placebo (other d…

    In this study, GHRP-2 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-2.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.