Skip to content

Study · In vitro (cells) · 1998

4 results

Cytokine-mediated apoptosis and inhibition of virus production and anchorage independent growth of viral transfected hepatoblastoma cells.

Yared G, Hussain KB, Nathani MG, Moshier JA, Dosescu J, Mutchnick MG, Naylor PH

Cytokine1 Aug 1998Cited by 7 (Europe PMC)

PMID9722931 (opens in a new tab)DOI10.1006/cyto.1998.0340 (opens in a new tab)PepBankPUB-09722931
Publisher pagePubMedAsk about this study
Jump to 4 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In HepG2 cells, thymosin alpha‑1 had no effect on apoptosis.

    In plain wordsIn cells, thymosin alpha‑1 did not change apoptosis.

    Peptide
    Thymosin alpha-1
    Outcome
    No significant changeApoptosis
    Study

    humann: not reported in source

    HepG2 cells transfected with HBV or SV-40
    Outcome group
    Infection and antimicrobial activity · Infection
    Studied dose
    Dose not stated

    Source sentences

    Summary
    IFN-alpha and T alpha 1 had no effect on apoptosis.
    2 context sentences
    Summary · context
    Cytokine-mediated apoptotic destruction of viral-infected cells, downregulation of virus production and inhibition of anchorage dependent (clonal) cell growth were evaluated using virus-transfected human hepatoblastoma (HepG2) cells.
    Summary · context
    The viruses evaluated were Hepatitis B (HBV) and the transforming virus, SV-40.
  2. 02LabIn vitro (cells)Efficacy outcome

    In transfected HepG2 cells, thymosin alpha‑1 inhibited clonal growth of only the HBV-transfected cells.

    In plain wordsIn cells, thymosin alpha‑1 slowed colony growth in only the HBV-transfected cell line.

    Peptide
    Thymosin alpha-1
    Outcome
    MixedAnchorage-independent clonal growth
    Study

    humann: not reported in source

    HepG2 cells transfected with HBV or SV-40
    Outcome group
    Tumor growth · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    IFN-alpha inhibited the clonal growth of all three cell lines in contrast to T alpha 1 which inhibited the clonal growth of only the HBV-transfected cells.
    2 context sentences
    Summary · context
    Cytokine-mediated apoptotic destruction of viral-infected cells, downregulation of virus production and inhibition of anchorage dependent (clonal) cell growth were evaluated using virus-transfected human hepatoblastoma (HepG2) cells.
    Summary · context
    The viruses evaluated were Hepatitis B (HBV) and the transforming virus, SV-40.
  3. 03LabIn vitro (cells)Efficacy outcome

    Thymosin alpha‑1 given alone did not significantly inhibit HBV-DNA production in the culture supernatant of HBV-HepG2 cells.

    In plain wordsIn cells, thymosin alpha‑1 alone did not significantly reduce hepatitis B virus DNA production.

    Peptide
    Thymosin alpha-1
    Outcome
    No significant changeHBV-DNA production, thymosin alpha 1 alone
    Study

    humann: not reported in source

    HepG2 cells transfected with HBV or SV-40
    Outcome group
    Antiviral activity · Infection
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Although TNF-alpha, IFN-alpha, and T alpha 1 when given alone did not significantly inhibit HBV-DNA production in the culture supernatant from HBV-HepG2 cells
    2 context sentences
    Summary · context
    Cytokine-mediated apoptotic destruction of viral-infected cells, downregulation of virus production and inhibition of anchorage dependent (clonal) cell growth were evaluated using virus-transfected human hepatoblastoma (HepG2) cells.
    Summary · context
    The viruses evaluated were Hepatitis B (HBV) and the transforming virus, SV-40.

Studies that did not test the peptide alone1

In this study, Thymosin alpha-1 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymosin alpha-1.

  1. 04LabNot a test of Thymosin alpha-1 aloneIn vitro (cells)Efficacy outcome

    The combination of thymosin alpha‑1 and IFN-alpha significantly inhibited virus production in HBV-HepG2 cells.

    In plain wordsIn cells, thymosin alpha‑1 together with interferon alpha significantly reduced hepatitis B virus production.

    Peptide
    Thymosin alpha-1
    Outcome
    DecreaseHBV-DNA production, thymosin alpha 1 plus IFN-alpha
    Study

    humann: not reported in source

    HepG2 cells transfected with HBV or SV-40
    Comparator
    Each cytokine alone
    Outcome group
    Antiviral activity · Infection

    Source sentences

    Summary
    the combination of T alpha 1 and IFN-alpha resulted in a statistically significant inhibition of virus production.
    2 context sentences
    Summary · context
    Cytokine-mediated apoptotic destruction of viral-infected cells, downregulation of virus production and inhibition of anchorage dependent (clonal) cell growth were evaluated using virus-transfected human hepatoblastoma (HepG2) cells.
    Summary · context
    The viruses evaluated were Hepatitis B (HBV) and the transforming virus, SV-40.

    In this study, Thymosin alpha-1 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin alpha-1.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    10 Oct 2026, 08:55 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 03:02 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.