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Study · Randomized controlled trial · n = 53 · 1998

3 results

Pre or post-operative medical treatment with nafarelin in stage III-IV endometriosis: a French multicenter study.

Audebert A, Descamps P, Marret H, Ory-Lavollee L, Bailleul F, Hamamah S

European journal of obstetrics, gynecology, and reproductive biology1 Aug 1998Cited by 29 (Europe PMC)

PMID9720832 (opens in a new tab)DOI10.1016/s0301-2115(98)00028-1 (opens in a new tab)PepBankPUB-09720832
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. 3 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In advanced endometriosis, clinical efficacy was the same with preoperative and postoperative nafarelin.

    In plain wordsClinical efficacy was the same with preoperative and postoperative nafarelin.

    Peptide
    Nafarelin
    Outcome
    No significant changeClinical efficacy
    Study

    n = 53

    Comparator
    Postoperative nafarelin
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    200 microg twice a day · intranasal · 6 monthsAs given in this study (human).

    Source sentences

    Summary
    Efficacy and tolerance to the treatment were the same in both groups.
    3 context sentences
    Summary · context
    The severity of endometriosis was assessed at the time of laparoscopy and patients were randomized to have either laparosopic surgery at that time following 6 months of nafarelin therapy (n=28), or laparoscopic surgery following 6 months of nafarelin therapy (n=25).
    Summary · context
    Fifty-five patients with stage III and IV endometriosis.
    Summary · context
    All had 200 microg intranasal nafarelin twice a day for 6 months and a second look laparoscopy.
  2. 02HumanRandomized controlled trialSafety outcome

    In advanced endometriosis, treatment tolerance was the same with preoperative and postoperative nafarelin.

    In plain wordsTreatment tolerance was the same with preoperative and postoperative nafarelin.

    Peptide
    Nafarelin
    Outcome
    No significant changeTreatment tolerance
    Study

    n = 53

    Comparator
    Postoperative nafarelin
    Outcome group
    Adverse events · Reproductive and sexual health
    Studied dose
    200 microg twice a day · intranasal · 6 monthsAs given in this study (human).

    Source sentences

    Summary
    Efficacy and tolerance to the treatment were the same in both groups.
    3 context sentences
    Summary · context
    The severity of endometriosis was assessed at the time of laparoscopy and patients were randomized to have either laparosopic surgery at that time following 6 months of nafarelin therapy (n=28), or laparoscopic surgery following 6 months of nafarelin therapy (n=25).
    Summary · context
    Fifty-five patients with stage III and IV endometriosis.
    Summary · context
    All had 200 microg intranasal nafarelin twice a day for 6 months and a second look laparoscopy.
  3. 03HumanRandomized controlled trialEfficacy outcome

    In advanced endometriosis, preoperative nafarelin produced better AFS scores than postoperative treatment (P=0.007).

    In plain wordsAFS scores improved more with preoperative than postoperative nafarelin.

    Peptide
    Nafarelin
    Outcome
    Direction not reportedAFS score improvement
    Study

    n = 53

    Comparator
    Postoperative nafarelin
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    200 microg twice a day · intranasal · 6 monthsAs given in this study (human).

    Source sentences

    Summary
    AFS scores compared on both laparoscopies were significantly better if nafarelin was given prior to surgery (P=0.007).
    3 context sentences
    Summary · context
    The severity of endometriosis was assessed at the time of laparoscopy and patients were randomized to have either laparosopic surgery at that time following 6 months of nafarelin therapy (n=28), or laparoscopic surgery following 6 months of nafarelin therapy (n=25).
    Summary · context
    Fifty-five patients with stage III and IV endometriosis.
    Summary · context
    All had 200 microg intranasal nafarelin twice a day for 6 months and a second look laparoscopy.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:36 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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