In vitro and in vivo effects of thymulin on rat testicular steroid synthesis.

Wise T

The Journal of steroid biochemistry and molecular biology1 Aug 1998Cited by 10 (Europe PMC)

PMID9719447DOI10.1016/s0960-0760(98)00045-4PepBankPUB-09719447

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study11

9 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In hypophysectomized rats, thymulin did not affect testicular steroidogenesis at the reported post-injection times.
In plain wordsIn rats without a pituitary gland, thymulin did not change testicular steroid production.
Peptide
Thymulin (serum thymic factor)
Outcome
No significant changeSteroidogenesis after hypophysectomy
Study
ratn: not reported in source
hypophysectomized 5-week-old rats
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
1 and 10 microg · intravenousAs given in this study (rat).
Source sentences
Summary
Thymulin had no effect on testicular steroidogenesis in hypophysectomized rats 30, 60, and 120 min post injection).
1 context sentence(design, population, supporting numbers)
Summary · context
Analysis of in vivo response to thymulin was pursued in pituitary intact, hypophysectomized and hCG primed (12 h before thymulin injection) hypophysectomized rats (5 weeks of age) with 1 and 10 microg of thymulin injected intravenously.
Report a problemFND-0971944707
02AnimalAnimal study (in vivo)Efficacy outcome
In pituitary-intact rats, thymulin reduced testosterone concentrations.
In plain wordsIn rats with an intact pituitary gland, thymulin reduced testosterone levels.
Peptide
Thymulin (serum thymic factor)
Outcome
DecreaseTestosterone in pituitary-intact rats
Study
ratn: not reported in source
pituitary-intact 5-week-old rats
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
1 and 10 microg · intravenousAs given in this study (rat).
Source sentences
Summary
In pituitary intact rats, thymulin reduced testosterone and estrone concentrations.
1 context sentence(design, population, supporting numbers)
Summary · context
Analysis of in vivo response to thymulin was pursued in pituitary intact, hypophysectomized and hCG primed (12 h before thymulin injection) hypophysectomized rats (5 weeks of age) with 1 and 10 microg of thymulin injected intravenously.
Report a problemFND-0971944708
03AnimalAnimal study (in vivo)Efficacy outcome
In pituitary-intact rats, thymulin reduced estrone concentrations.
In plain wordsIn rats with an intact pituitary gland, thymulin reduced estrone levels.
Peptide
Thymulin (serum thymic factor)
Outcome
DecreaseEstrone in pituitary-intact rats
Study
ratn: not reported in source
pituitary-intact 5-week-old rats
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
1 and 10 microg · intravenousAs given in this study (rat).
Source sentences
Summary
In pituitary intact rats, thymulin reduced testosterone and estrone concentrations.
1 context sentence(design, population, supporting numbers)
Summary · context
Analysis of in vivo response to thymulin was pursued in pituitary intact, hypophysectomized and hCG primed (12 h before thymulin injection) hypophysectomized rats (5 weeks of age) with 1 and 10 microg of thymulin injected intravenously.
Report a problemFND-0971944709
04LabEx vivo tissueEfficacy outcome
In testis from young rats, thymulin decreased testosterone synthesis.
In plain wordsIn lab tests, thymulin decreased testosterone production in testis from young rats.
Peptide
Thymulin (serum thymic factor)
Outcome
DecreaseTestosterone synthesis at three weeks
Study
ratn: not reported in source
testis from 3-week-old rats
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated
Source sentences
Summary
At three weeks of age, thymulin decreased testosterone and estrone synthesis.
1 context sentence(design, population, supporting numbers)
Summary · context
Effects of thymulin and thymulin augmentation of human chorionic gonadotropin (hCG) stimulation of testicular steroidogenesis were analyzed via incubation of testis from 3-, 6-, and 9-week-old rats with 0.1, 1, 10, and 100 ng/ml of thymulin or thymulin plus hCG (1 IU/ml).
Report a problemFND-0971944701
05LabEx vivo tissueEfficacy outcome
In testis from young rats, thymulin decreased estrone synthesis.
In plain wordsIn lab tests, thymulin decreased estrone production in testis from young rats.
Peptide
Thymulin (serum thymic factor)
Outcome
DecreaseEstrone synthesis at three weeks
Study
ratn: not reported in source
testis from 3-week-old rats
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated
Source sentences
Summary
At three weeks of age, thymulin decreased testosterone and estrone synthesis.
1 context sentence(design, population, supporting numbers)
Summary · context
Effects of thymulin and thymulin augmentation of human chorionic gonadotropin (hCG) stimulation of testicular steroidogenesis were analyzed via incubation of testis from 3-, 6-, and 9-week-old rats with 0.1, 1, 10, and 100 ng/ml of thymulin or thymulin plus hCG (1 IU/ml).
Report a problemFND-0971944702
06LabEx vivo tissueEfficacy outcome
In testis from older rats, lower thymulin doses stimulated testosterone synthesis.
In plain wordsIn lab tests, lower thymulin doses increased testosterone production in testis from older rats.
Peptide
Thymulin (serum thymic factor)
Outcome
IncreaseTestosterone synthesis at six and nine weeks
Study
ratn: not reported in source
testis from 6- and 9-week-old rats
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
0.1 and 1 ng/mlAs given in this study (rat).
Source sentences
Summary
By 6 and 9 weeks of age, lower doses of thymulin (0.1 and 1 ng/ml) stimulated testosterone and estrone synthesis.
1 context sentence(design, population, supporting numbers)
Summary · context
Effects of thymulin and thymulin augmentation of human chorionic gonadotropin (hCG) stimulation of testicular steroidogenesis were analyzed via incubation of testis from 3-, 6-, and 9-week-old rats with 0.1, 1, 10, and 100 ng/ml of thymulin or thymulin plus hCG (1 IU/ml).
Report a problemFND-0971944703
07LabEx vivo tissueEfficacy outcome
In testis from older rats, lower thymulin doses stimulated estrone synthesis.
In plain wordsIn lab tests, lower thymulin doses increased estrone production in testis from older rats.
Peptide
Thymulin (serum thymic factor)
Outcome
IncreaseEstrone synthesis at six and nine weeks
Study
ratn: not reported in source
testis from 6- and 9-week-old rats
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
0.1 and 1 ng/mlAs given in this study (rat).
Source sentences
Summary
By 6 and 9 weeks of age, lower doses of thymulin (0.1 and 1 ng/ml) stimulated testosterone and estrone synthesis.
1 context sentence(design, population, supporting numbers)
Summary · context
Effects of thymulin and thymulin augmentation of human chorionic gonadotropin (hCG) stimulation of testicular steroidogenesis were analyzed via incubation of testis from 3-, 6-, and 9-week-old rats with 0.1, 1, 10, and 100 ng/ml of thymulin or thymulin plus hCG (1 IU/ml).
Report a problemFND-0971944704
08LabEx vivo tissueEfficacy outcome
In rat testis cultures, high-dose thymulin decreased testicular steroid synthesis.
In plain wordsIn lab tests, high-dose thymulin decreased steroid production in rat testis.
Peptide
Thymulin (serum thymic factor)
Outcome
DecreaseTesticular steroid synthesis at high dose
Study
ratn: not reported in source
rat testis
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
100 ng/mlAs given in this study (rat).
Source sentences
Summary
Increased doses of thymulin (100 ng/ml) resulted in decreased testicular steroid synthesis.
1 context sentence(design, population, supporting numbers)
Summary · context
Effects of thymulin and thymulin augmentation of human chorionic gonadotropin (hCG) stimulation of testicular steroidogenesis were analyzed via incubation of testis from 3-, 6-, and 9-week-old rats with 0.1, 1, 10, and 100 ng/ml of thymulin or thymulin plus hCG (1 IU/ml).
Report a problemFND-0971944705
09LabEx vivo tissueEfficacy outcome
In rat testis cultures, thymulin did not augment hCG-stimulated steroidogenesis.
In plain wordsIn lab tests, thymulin did not increase steroid production beyond hCG stimulation alone.
Peptide
Thymulin (serum thymic factor)
Outcome
No significant changeAugmentation of hCG-stimulated steroidogenesis
Study
ratn: not reported in source
rat testis with hCG
Comparator
hCG stimulation without thymulin
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated
Source sentences
Summary
No thymulin augmentation of hCG stimulation of testicular steroidogenesis was noted in vitro.
1 context sentence(design, population, supporting numbers)
Summary · context
Effects of thymulin and thymulin augmentation of human chorionic gonadotropin (hCG) stimulation of testicular steroidogenesis were analyzed via incubation of testis from 3-, 6-, and 9-week-old rats with 0.1, 1, 10, and 100 ng/ml of thymulin or thymulin plus hCG (1 IU/ml).
Report a problemFND-0971944706

Studies that did not test the peptide alone2

In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymulin (serum thymic factor).

10AnimalNot a test of Thymulin (serum thymic factor) aloneAnimal study (in vivo)Efficacy outcome
In hCG-primed hypophysectomized rats, thymulin injection preceded significant testosterone increases.
In plain wordsIn rats without a pituitary gland, testosterone increased after hCG priming and thymulin injection.
Peptide
Thymulin (serum thymic factor)
Outcome
IncreaseTestosterone after hCG priming
Study
ratn: not reported in source
hCG-primed hypophysectomized rats
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Source sentences
Summary
In hCG primed hypophysectomized rats, thymulin injection was followed by significant increases in testosterone levels and declines in estrone concentrations.
1 context sentence(design, population, supporting numbers)
Summary · context
Analysis of in vivo response to thymulin was pursued in pituitary intact, hypophysectomized and hCG primed (12 h before thymulin injection) hypophysectomized rats (5 weeks of age) with 1 and 10 microg of thymulin injected intravenously.
In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymulin (serum thymic factor).
Report a problemFND-0971944710
11AnimalNot a test of Thymulin (serum thymic factor) aloneAnimal study (in vivo)Efficacy outcome
In hCG-primed hypophysectomized rats, thymulin injection preceded estrone declines.
In plain wordsIn rats without a pituitary gland, estrone decreased after hCG priming and thymulin injection.
Peptide
Thymulin (serum thymic factor)
Outcome
DecreaseEstrone after hCG priming
Study
ratn: not reported in source
hCG-primed hypophysectomized rats
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Source sentences
Summary
In hCG primed hypophysectomized rats, thymulin injection was followed by significant increases in testosterone levels and declines in estrone concentrations.
1 context sentence(design, population, supporting numbers)
Summary · context
Analysis of in vivo response to thymulin was pursued in pituitary intact, hypophysectomized and hCG primed (12 h before thymulin injection) hypophysectomized rats (5 weeks of age) with 1 and 10 microg of thymulin injected intravenously.
In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymulin (serum thymic factor).
Report a problemFND-0971944711

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 3Current
21 Oct 2026, 15:58 UTC
Study results updated
Version 2
21 Oct 2026, 13:55 UTC
Study data updated · source update from Europe PMC
Version 1
21 Oct 2026, 12:50 UTC
First added · source update from Europe PMC

Subjects

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Publication types

Journal Article

MeSH terms

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