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Study · Not a test of the peptide alone · 1998

4 results

Humoral and cell-mediated immunopotentiation in vaccinated chicken layers by thymic hormones and zinc.

Barbour EK, Hamadeh SK, Ghanem DA, Haddad JJ, Safieh-Garabedian B

Vaccine1 Oct 1998Cited by 12 (Europe PMC)

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone4

In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymulin (serum thymic factor).

  1. 01AnimalNot a test of Thymulin (serum thymic factor) aloneAnimal study (in vivo)Efficacy outcome

    In vaccinated chickens, thymulin-ZnCl2 produced the highest IBV humoral immunopotentiation among combinations, with mean titer increasing 199% from baseline.

    In plain wordsIn vaccinated chickens, thymulin-ZnCl2 produced the highest IBV antibody response among combinations, with antibody levels increasing 199% from baseline.

    Outcome
    IncreaseIBV antibody titer
    Study

    chickenn: not reported in source

    vaccinated white leghorn-chicken layers
    Comparator
    initial titer at 29 weeks and other tested combinations
    Outcome group
    Immune response · Immune and inflammation

    Measurements

    Mean titer increase
    199%
    IBV at 33 versus 29 weeks

    Source sentences

    Summary
    Among all combinations, the thymulin-ZnCl2 resulted in birds with the highest humoral immunopotentiation to IBV, IBDV, and NDV antigens with respective percent increase in the mean titer at 33 weeks of age, compared with initial titer at 29 weeks of age, equivalent to 199%, 671.7%, and 86.4%.
    1 context sentence
    Summary · context
    Four out of the five vaccinated groups were immunopotentiated by various combinations of zinc and thymic hormones administered intraperitoneally in a volume of 0.1 ml per bird at an interval of three days for a period of three weeks, starting at 29 weeks of age.

    In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymulin (serum thymic factor).

  2. 02AnimalNot a test of Thymulin (serum thymic factor) aloneAnimal study (in vivo)Efficacy outcome

    In vaccinated chickens, thymulin-ZnCl2 produced the highest IBDV humoral immunopotentiation among combinations, with mean titer increasing 671.7% from baseline.

    In plain wordsIn vaccinated chickens, thymulin-ZnCl2 produced the highest IBDV antibody response among combinations, with antibody levels increasing 671.7% from baseline.

    Outcome
    IncreaseIBDV antibody titer
    Study

    chickenn: not reported in source

    vaccinated white leghorn-chicken layers
    Comparator
    initial titer at 29 weeks and other tested combinations
    Outcome group
    Immune response · Immune and inflammation

    Measurements

    Mean titer increase
    671.7%
    IBDV at 33 versus 29 weeks

    Source sentences

    Summary
    Among all combinations, the thymulin-ZnCl2 resulted in birds with the highest humoral immunopotentiation to IBV, IBDV, and NDV antigens with respective percent increase in the mean titer at 33 weeks of age, compared with initial titer at 29 weeks of age, equivalent to 199%, 671.7%, and 86.4%.
    1 context sentence
    Summary · context
    Four out of the five vaccinated groups were immunopotentiated by various combinations of zinc and thymic hormones administered intraperitoneally in a volume of 0.1 ml per bird at an interval of three days for a period of three weeks, starting at 29 weeks of age.

    In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymulin (serum thymic factor).

  3. 03AnimalNot a test of Thymulin (serum thymic factor) aloneAnimal study (in vivo)Efficacy outcome

    In vaccinated chickens, thymulin-ZnCl2 produced the highest NDV humoral immunopotentiation among combinations, with mean titer increasing 86.4% from baseline.

    In plain wordsIn vaccinated chickens, thymulin-ZnCl2 produced the highest NDV antibody response among combinations, with antibody levels increasing 86.4% from baseline.

    Outcome
    IncreaseNDV antibody titer
    Study

    chickenn: not reported in source

    vaccinated white leghorn-chicken layers
    Comparator
    initial titer at 29 weeks and other tested combinations
    Outcome group
    Immune response · Immune and inflammation

    Measurements

    Mean titer increase
    86.4%
    NDV at 33 versus 29 weeks

    Source sentences

    Summary
    Among all combinations, the thymulin-ZnCl2 resulted in birds with the highest humoral immunopotentiation to IBV, IBDV, and NDV antigens with respective percent increase in the mean titer at 33 weeks of age, compared with initial titer at 29 weeks of age, equivalent to 199%, 671.7%, and 86.4%.
    1 context sentence
    Summary · context
    Four out of the five vaccinated groups were immunopotentiated by various combinations of zinc and thymic hormones administered intraperitoneally in a volume of 0.1 ml per bird at an interval of three days for a period of three weeks, starting at 29 weeks of age.

    In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymulin (serum thymic factor).

  4. 04AnimalNot a test of Thymulin (serum thymic factor) aloneAnimal study (in vivo)Efficacy outcome

    In vaccinated chickens, the thymulin-thymopoietin-ZnCl2 combination produced the highest delayed hypersensitivity reaction among the tested regimens.

    In plain wordsIn chickens, thymulin-thymopoietin-ZnCl2 produced the highest delayed immune reaction among the tested regimens.

    Outcome
    IncreaseDelayed hypersensitivity reaction
    Study

    chickenn: not reported in source

    vaccinated white leghorn-chicken layers
    Comparator
    other tested immunopotentiation regimens
    Outcome group
    Immune response · Immune and inflammation

    Source sentences

    Summary
    The highest cell-mediated delayed hypersensitivity reaction, measured at 48 h following an intradermal administration of the trivalent vaccine in the wattles at 33 weeks of age, was obtained in chickens immunopotentiated by the thymulin-thymopoietin-ZnCl2 combination.
    1 context sentence
    Summary · context
    Four out of the five vaccinated groups were immunopotentiated by various combinations of zinc and thymic hormones administered intraperitoneally in a volume of 0.1 ml per bird at an interval of three days for a period of three weeks, starting at 29 weeks of age.

    In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymulin (serum thymic factor).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 2

    21 Oct 2026, 13:55 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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