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Study · Animal study (in vivo) · rat · 1998

4 results

Intermittent administration of parathyroid hormone (1-34) stimulates matrix metalloproteinase-9 (MMP-9) expression in rat long bone.

McClelland P, Onyia JE, Miles RR, Tu Y, Liang J, Harvey AK, Chandrasekhar S, Hock JM, Bidwell JP

Journal of cellular biochemistry1 Sept 1998Cited by 38 (Europe PMC)

PMID9706876 (opens in a new tab)DOI10.1002/(sici)1097-4644(19980901)70:3<391::aid-jcb12>3.0.co;2-o (opens in a new tab)PepBankPUB-09706876
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In rats, PTH increased MMP-9 expression during bone formation.

    In plain wordsIn rats, PTH increased MMP-9 gene activity during bone formation versus vehicle.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseMMP-9 expression
    Study

    Ratn: not reported in source

    Young male rats
    Comparator
    Vehicle
    Outcome group
    Receptor activity and mechanism · Musculoskeletal
    Studied dose
    Once daily · injection · 5 daysAs given in this study (Rat).

    Source sentences

    Summary
    The concomitant upregulation of MMP-9 and COL1A1 during bone formation was particularly intriguing.
    1 context sentence
    Summary · context
    To identify novel PTH-regulated genes in bone during the anabolic response, we used differential display-polymerase chain reaction (DDRT-PCR) to analyze RNA from young male rats injected with either human PTH (1-34) or vehicle control, once daily for 5 days.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In rats, PTH increased COL1A1 expression during bone formation.

    In plain wordsIn rats, PTH increased collagen gene activity during bone formation versus vehicle.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseCOL1A1 expression
    Study

    Ratn: not reported in source

    Young male rats
    Comparator
    Vehicle
    Outcome group
    Receptor activity and mechanism · Musculoskeletal
    Studied dose
    Once daily · injection · 5 daysAs given in this study (Rat).

    Source sentences

    Summary
    The concomitant upregulation of MMP-9 and COL1A1 during bone formation was particularly intriguing.
    1 context sentence
    Summary · context
    To identify novel PTH-regulated genes in bone during the anabolic response, we used differential display-polymerase chain reaction (DDRT-PCR) to analyze RNA from young male rats injected with either human PTH (1-34) or vehicle control, once daily for 5 days.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In rats, creatine kinase was identified as a PTH-responsive transcript.

    In plain wordsIn rats, creatine kinase gene activity responded to PTH versus vehicle, but the direction was not stated.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    Direction not reportedCreatine kinase transcript response
    Study

    Ratn: not reported in source

    Young male rats
    Comparator
    Vehicle
    Outcome group
    Receptor activity and mechanism · Musculoskeletal
    Studied dose
    Once daily · injection · 5 daysAs given in this study (Rat).

    Source sentences

    Summary
    We identified three PTH-responsive transcripts as matrix metalloproteinase-9 (MMP-9), creatine kinase, and the alpha1 (I) polypeptide chain (COL1A1) of type I collagen.
    1 context sentence
    Summary · context
    To identify novel PTH-regulated genes in bone during the anabolic response, we used differential display-polymerase chain reaction (DDRT-PCR) to analyze RNA from young male rats injected with either human PTH (1-34) or vehicle control, once daily for 5 days.
  4. 04LabIn vitro (cells)Mechanism

    In vitro, PTH regulated MMP-9 protein synthesis by primary spongiosa osteoblasts.

    In plain wordsIn lab tests, PTH regulated MMP-9 protein production in bone-forming cells.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    Direction not reportedMMP-9 protein synthesis
    Study

    Ratn: not reported in source

    Osteoblasts of primary spongiosa
    Outcome group
    Receptor activity and mechanism · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In vitro, PTH regulated the protein synthesis of MMP-9 by osteoblasts of the primary spongiosa.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

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