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Study · Randomized controlled trial · n = 48 · 1998

8 results

Dose-dependent effects of Cerebrolysin on EEG and short-term memory of healthy volunteers during control and hyperventilation induced cerebral ischemia.

Funke M, Fiehler J, Mewes I, Eiselt M, Rother I, Windisch M

Journal of neural transmission. Supplementum1 Jan 1998Cited by 6 (Europe PMC)

PMID9700674 (opens in a new tab)DOI10.1007/978-3-7091-6467-9_34 (opens in a new tab)PepBankPUB-09700674
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. 8 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In healthy males, Cerebrolysin groups did not show the early trend toward poorer word recall observed with placebo.

    In plain wordsIn healthy men, Cerebrolysin groups did not show the early trend toward poorer word recall seen with placebo.

    Peptide
    Cerebrolysin
    Outcome
    Not applicableShort-term word recall
    Study

    n = 48

    Comparator
    Placebo
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    10 ml or 30 ml or 50 ml · infusion · 10 daysAs given in this study (human).

    Source sentences

    Summary
    For short term memory, there is a trend towards less effective word recall for the baseline situation during the first 4 hours for the placebo. This effect was not observed in the Cerebrolysin treated groups.
    1 context sentence
    Summary · context
    In this single centre, double blind, randomized, placebo-controlled, parallel group study 48 healthy males were enrolled and received either 100 ml placebo (NaCl) or Cerebrolysin (10 ml or 30 ml or 50 ml) in a volume of 100 ml (NaCl) for 10 days.
  2. 02HumanRandomized controlled trialActivity measurement

    In healthy males, Cerebrolysin increased baseline EEG power ratio, most prominently in the parietal cortex.

    In plain wordsIn healthy men, Cerebrolysin increased baseline EEG power ratio, especially over the parietal cortex.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseAcute baseline EEG power ratio
    Study

    n: not reported in source

    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    10 ml · infusion · 10 daysAs given in this study (human).

    Source sentences

    Summary
    The main effects found during the study can be summarized as follows: At baseline we found an increase of the EEG power ratio (PR) for the grouptrated with 10 ml Cerebrolysin.
    3 context sentences
    Summary · context
    The effect was most pronounced at the parietal cortex.
    Summary · context
    The effect started after 15 min, was most expressed at 2 h and was kept until 8 h.
    Summary · context
    In this single centre, double blind, randomized, placebo-controlled, parallel group study 48 healthy males were enrolled and received either 100 ml placebo (NaCl) or Cerebrolysin (10 ml or 30 ml or 50 ml) in a volume of 100 ml (NaCl) for 10 days.
  3. 03HumanRandomized controlled trialActivity measurement

    In healthy males, Cerebrolysin reduced relative EEG power ratio during hyperventilation at 2 hours.

    In plain wordsIn healthy men, Cerebrolysin reduced relative EEG power ratio during hyperventilation at 2 hours.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseEEG power ratio during hyperventilation
    Study

    n: not reported in source

    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    10 ml · infusion · 10 daysAs given in this study (human).

    Source sentences

    Summary
    During HV we found a relative PR decrease of the group (10 ml Cerebrolysin) at 2 hours.
    1 context sentence
    Summary · context
    In this single centre, double blind, randomized, placebo-controlled, parallel group study 48 healthy males were enrolled and received either 100 ml placebo (NaCl) or Cerebrolysin (10 ml or 30 ml or 50 ml) in a volume of 100 ml (NaCl) for 10 days.
  4. 04HumanRandomized controlled trialActivity measurement

    In healthy males, Cerebrolysin increased parietal EEG power ratio at 24 h, with persistence at day 10 and 11.

    In plain wordsIn healthy men, Cerebrolysin increased parietal EEG power ratio at 24 h, with persistence at day 10 and 11.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseChronic parietal EEG power ratio
    Study

    n: not reported in source

    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    10 ml · infusion · 10 daysAs given in this study (human).

    Source sentences

    Summary
    If chronic effects are concerned, the PR increased over the parietal regions at 24 h for the groups treated with 10 and 30 ml Cerebrolysin. The effect remains at day 10 and 11.
    1 context sentence
    Summary · context
    In this single centre, double blind, randomized, placebo-controlled, parallel group study 48 healthy males were enrolled and received either 100 ml placebo (NaCl) or Cerebrolysin (10 ml or 30 ml or 50 ml) in a volume of 100 ml (NaCl) for 10 days.
  5. 05HumanRandomized controlled trialActivity measurement

    In healthy males, Cerebrolysin increased parietal EEG power ratio at 24 h, with persistence at day 10 and 11.

    In plain wordsIn healthy men, Cerebrolysin increased parietal EEG power ratio at 24 h, with persistence at day 10 and 11.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseChronic parietal EEG power ratio
    Study

    n: not reported in source

    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    30 ml · infusion · 10 daysAs given in this study (human).

    Source sentences

    Summary
    If chronic effects are concerned, the PR increased over the parietal regions at 24 h for the groups treated with 10 and 30 ml Cerebrolysin. The effect remains at day 10 and 11.
    1 context sentence
    Summary · context
    In this single centre, double blind, randomized, placebo-controlled, parallel group study 48 healthy males were enrolled and received either 100 ml placebo (NaCl) or Cerebrolysin (10 ml or 30 ml or 50 ml) in a volume of 100 ml (NaCl) for 10 days.
  6. 06HumanRandomized controlled trialActivity measurement

    In healthy males, Cerebrolysin showed a trend toward increased relative EEG power ratio at 10 and 11 days.

    In plain wordsIn healthy men, Cerebrolysin showed a trend toward increased relative EEG power ratio at 10 and 11 days.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseChronic EEG power ratio trend
    Study

    n: not reported in source

    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    50ml · infusion · 10 daysAs given in this study (human).

    Source sentences

    Summary
    But at 10 and 11 days there was also a trend for a relative increase of the PR in the group treated with 50ml Cerebrolysin.
    1 context sentence
    Summary · context
    In this single centre, double blind, randomized, placebo-controlled, parallel group study 48 healthy males were enrolled and received either 100 ml placebo (NaCl) or Cerebrolysin (10 ml or 30 ml or 50 ml) in a volume of 100 ml (NaCl) for 10 days.
  7. 07HumanRandomized controlled trialSafety outcome

    In healthy males, the highest Cerebrolysin concentration produced mild signs of overdosage that caused no harm.

    In plain wordsIn healthy men, the highest Cerebrolysin concentration produced mild signs of overdosage that caused no harm.

    Peptide
    Cerebrolysin
    Outcome
    Not applicableSigns of overdosage
    Study

    n: not reported in source

    Outcome group
    Adverse events · Whole body
    Studied dose
    50 ml · infusion · 10 daysAs given in this study (human).

    Source sentences

    Summary
    Signs of overdosage occurred with the highest concentrations of Cerebrolysin. The events were only mild and caused no harm to the volunteers.
    1 context sentence
    Summary · context
    In this single centre, double blind, randomized, placebo-controlled, parallel group study 48 healthy males were enrolled and received either 100 ml placebo (NaCl) or Cerebrolysin (10 ml or 30 ml or 50 ml) in a volume of 100 ml (NaCl) for 10 days.
  8. 08HumanRandomized controlled trialSafety outcome

    In healthy males, the highest Cerebrolysin concentration caused a small significant reduction in blood pressure.

    In plain wordsIn healthy men, the highest Cerebrolysin concentration caused a small significant reduction in blood pressure.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseBlood pressure
    Study

    n: not reported in source

    Outcome group
    Blood pressure · Cardiovascular
    Studied dose
    50 ml · infusion · 10 daysAs given in this study (human).

    Source sentences

    Summary
    The highest concentration caused a small but significant reduction of blood pressure.
    1 context sentence
    Summary · context
    In this single centre, double blind, randomized, placebo-controlled, parallel group study 48 healthy males were enrolled and received either 100 ml placebo (NaCl) or Cerebrolysin (10 ml or 30 ml or 50 ml) in a volume of 100 ml (NaCl) for 10 days.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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