Skip to content

Study · In vitro (cells) · chicken · 1998

4 results

Further evidence that Cerebrolysin protects cortical neurons from neurodegeneration in vitro.

Hutter-Paier B, Grygar E, Frühwirth M, Temmel I, Windisch M

Journal of neural transmission. Supplementum1 Jan 1998Cited by 19 (Europe PMC)

PMID9700672 (opens in a new tab)DOI10.1007/978-3-7091-6467-9_32 (opens in a new tab)PepBankPUB-09700672
Publisher pagePubMedAsk about this study
Jump to 4 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Efficacy outcome

    In chicken cortical neurons, Cerebrolysin prevented iron-induced neurodegeneration.

    In plain wordsIn cells from chicken brains, Cerebrolysin prevented iron-induced degeneration.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseIron-induced neurodegeneration
    Study

    chickenn: not reported in source

    Isolated cortical neurons
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Cerebrolysin not only prevented iron induced neurodegeneration
    1 context sentence
    Summary · context
    The effects of Cerebrolysin on isolated chicken cortical neurons in an iron induced oxidative stress model and in a combined iron-glutamate model have been examined.
  2. 02LabIn vitro (cells)Efficacy outcome

    In chicken cortical neurons, Cerebrolysin increased neuronal viability up to tenfold compared with controls.

    In plain wordsIn cells from chicken brains, Cerebrolysin increased cell viability up to tenfold compared with controls.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseNeuronal viability
    Study

    chickenn: not reported in source

    Isolated cortical neurons
    Comparator
    Controls
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    moreover, it increased the neuronal viability up to tenfold with respect to the controls.
    1 context sentence
    Summary · context
    The effects of Cerebrolysin on isolated chicken cortical neurons in an iron induced oxidative stress model and in a combined iron-glutamate model have been examined.
  3. 03LabIn vitro (cells)Efficacy outcome

    In iron-pretreated chicken cortical neurons, Cerebrolysin counteracted glutamate-induced destructive effects.

    In plain wordsIn cells from chicken brains pretreated with iron, Cerebrolysin reduced glutamate-induced damage.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseGlutamate-induced neuronal damage
    Study

    chickenn: not reported in source

    Isolated cortical neurons
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Under these conditions cerebrolysin again clearly counteracted the in vitro destructive effects of glutamate.
    2 context sentences
    Summary · context
    In the second part of the study neurons pre-incubated for 8 days with AC-Fe3+ were additionally lesioned with 1 mM L-glutamate and allowed to recover for another 48 h.
    Summary · context
    The effects of Cerebrolysin on isolated chicken cortical neurons in an iron induced oxidative stress model and in a combined iron-glutamate model have been examined.
  4. 04LabIn vitro (cells)Mechanism

    In chicken cortical neurons, Cerebrolysin increased MAP2 abundance.

    In plain wordsIn cells from chicken brains, Cerebrolysin increased MAP2 protein.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseMAP2 abundance
    Study

    chickenn: not reported in source

    Isolated cortical neurons
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Besides consequences on the viability and survival of neurons Cerebrolysin increased abundance of the microtubule-associated protein MAP2, which is known to play a an important role in maintaining normal neuronal function.
    1 context sentence
    Summary · context
    The effects of Cerebrolysin on isolated chicken cortical neurons in an iron induced oxidative stress model and in a combined iron-glutamate model have been examined.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

PepBank is a research reference. Talk to a doctor before you use any peptide.