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Study · In vitro (cells) · chicken · 1998

3 results

Cerebrolysin protects isolated cortical neurons from neurodegeneration after brief histotoxic hypoxia.

Hutter-Paier B, Steiner E, Windisch M

Journal of neural transmission. Supplementum1 Jan 1998Cited by 19 (Europe PMC)

PMID9700671 (opens in a new tab)DOI10.1007/978-3-7091-6467-9_31 (opens in a new tab)PepBankPUB-09700671
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Efficacy outcome

    In chicken cortical neurons, Cerebrolysin dose-dependently protected against delayed cell death after 0.01 mM iodoacetate through 48h recovery.

    In plain wordsIn cells from chicken brains, Cerebrolysin protected against delayed cell death after 0.01 mM iodoacetate.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseDelayed neuronal cell death after low iodoacetate
    Study

    chickenn: not reported in source

    Isolated embryonic cortical neurons
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    0 to 6.4 mg.Cere/ml mediumAs given in this study (chicken).

    Source sentences

    Summary
    Cere protected neurons dose dependently from delayed neuronal cell death due to 0.01 mM iodoacetate even after a recovery period of 48h.
    2 context sentences
    Summary · context
    For that purpose isolated cortical neurons from 9 day chicken embryos were precultured with 0 to 6.4 mg.Cere/ml medium.
    Summary · context
    At the 8th day in vitro histotoxic hypoxia was induced by incubation with 0.01 or 0.1 mM iodoacetate.
  2. 02LabIn vitro (cells)Efficacy outcome

    In chicken cortical neurons, high Cerebrolysin concentrations protected neurons after 0.1 mM iodoacetate at 3 and 6 h recovery.

    In plain wordsIn cells from chicken brains, high Cerebrolysin concentrations protected neurons after 0.1 mM iodoacetate.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseNeuronal protection after high iodoacetate
    Study

    chickenn: not reported in source

    Isolated embryonic cortical neurons
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    After induction of histotoxic hypoxia by 0.1 mM iodoacetate high concentrations of Cere again led to neuronal protection after the 3 and 6 h recovery period.
    2 context sentences
    Summary · context
    For that purpose isolated cortical neurons from 9 day chicken embryos were precultured with 0 to 6.4 mg.Cere/ml medium.
    Summary · context
    At the 8th day in vitro histotoxic hypoxia was induced by incubation with 0.01 or 0.1 mM iodoacetate.
  3. 03LabIn vitro (cells)Mechanism

    In chicken cortical neurons, Cerebrolysin increased MAP2 abundance after histotoxic hypoxia.

    In plain wordsIn cells from chicken brains, Cerebrolysin increased MAP2 protein after toxic oxygen deprivation.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseMAP2 abundance
    Study

    chickenn: not reported in source

    Isolated embryonic cortical neurons
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    0 to 6.4 mg.Cere/ml mediumAs given in this study (chicken).

    Source sentences

    Summary
    With Western blotting and immunohistochemical techniques it has been demonstrated that the drug clearly increased MAP2 abundance after histotoxic hypoxia.
    3 context sentences
    Summary · context
    Moreover the influence of Cere on the cytoskeletal protein MAP2 in neurons submitted to 0.01 mM iodoacetate was investigated.
    Summary · context
    For that purpose isolated cortical neurons from 9 day chicken embryos were precultured with 0 to 6.4 mg.Cere/ml medium.
    Summary · context
    At the 8th day in vitro histotoxic hypoxia was induced by incubation with 0.01 or 0.1 mM iodoacetate.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

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